Abstract: A device for producing a fluid containing a radioactive constituent, comprising a shielded chamber (5) with an opening for receiving an isotope container (6) housing a radioactive isotope (7); a chamber closure (18) adapted for cooperating with and closing the chamber opening; a first fluid port comprising a first hollow needle projecting into the shielded chamber from the chamber closure for fluid communication with the isotope container; a second fluid port comprising a second hollow needle projecting into the shielded chamber from the closed end of the chamber opposite the chamber closure for fluid communication with the isotope container; first and second compressible buffers (28, 29) mounted so as to surround at least partially the respective first and second hollow needles (12, 13), each buffer providing an outer surface for contact with opposed ends of the isotope container; and a spacer of a predetermined thickness associated with one or each of the first and second compressible buffers for determinin

Abstract: The present invention provides an automated method for the preparation of 99mTc radiopharmaceutical compositions, together with disposable cassettes for use in the method. The use of an automated synthesizer apparatus in the preparation of 99mTc radiopharmaceuticals is also described. Also described is the use of kits for the preparation of 99mTc radiopharmaceuticals in the method and disposable cassettes of the present invention.

Abstract: The invention relates to a device for producing a fluid containing a radioactive constituent, the device comprising: a shielded chamber (5) within which is located an isotope container (6) housing a radioactive isotope (7), the shielded chamber including first and second fluid connections (12,13) to opposing ends of the isotope container and a fluid conduit (14,15) extending from each of the first and second fluid connections to a fluid inlet (16) and a fluid outlet (17) respectively characterised in that the fluid inlet comprises a single spike (22) having a substantially circular cross-section, the spike being adapted to penetrate the rubber seal of a vial and the spike having two bores, the first bore extending from a first aperture adjacent the tip of the spike to a fluid connection with the fluid conduit and the second bore extending from a second, separate aperture in the spike to a filtering air inlet.