Abstract: An apparatus for reducing condensation on water lines has a sensor for measuring dew point of ambient air, a first inlet for receiving cold water, a second inlet for receiving hot water, and an outlet. Further, the apparatus has a manifold in fluid communication with the first inlet, the second inlet, and the outlet, a valve for controlling the flow of hot water from the second inlet into the manifold, and an actuator configured to adjust the valve. The apparatus has a controller coupled to the first sensor and the actuator for controlling the actuator to adjust a quantity of hot water that is mixed with cold water at the outlet based on one or more dew point measurements from the sensor.

Abstract: A system may be configured to conflate vectorized source data. Some embodiments may: obtain first data from a first source and second data from a second source; determine a first polygon that encloses all features of the first data and a second polygon that encloses all features of the second data; determine a larger polygon that encloses the first and second polygons; divide the larger polygon into first tiles; extract, from each of the first tiles overlaying the first data and from the each tile overlaying the second data, a first set of features and a second set of features, respectively; and identify, based on a computed disagreement level satisfying a set of criteria, each of one or more of the tiles. A set of identified tiles or all of the tiles may then be displayed, including shaded indicators overlaying features of respective portions of the first and second data.

Abstract: A system may be configured to collect geospatial features (in vector form) such that a software application is operable to edit an object represented by at least one vector. Some embodiments may: generate, via a trained machine learning model, a pixel map based on an aerial or satellite image; convert the pixel map into vector form; and store the vectors. This conversion may include a raster phase and a vector phase. A system may be configured to obtain another image, generate another pixel map based on the other image, convert the other pixel map into vector form, and compare the vectors to identify changes between the images. Some implementations may cause identification, based on a similarity with converted vectors, of a more trustworthy set of vectors for subsequent data source conflation.

Abstract: A system may be configured to collect geospatial features (in vector form) such that a software application is operable to edit an object represented by at least one vector. Some embodiments may: generate, via a trained machine learning model, a pixel map based on an aerial or satellite image; convert the pixel map into vector form; and store the vectors. This conversion may include a raster phase and a vector phase. A system may be configured to obtain another image, generate another pixel map based on the other image, convert the other pixel map into vector form, and compare the vectors to identify changes between the images. Some implementations may cause identification, based on a similarity with converted vectors, of a more trustworthy set of vectors for subsequent data source conflation.

Abstract: A system may be configured to conflate vectorized source data. Some embodiments may: obtain first data from a first source and second data from a second source; determine a first polygon that encloses all features of the first data and a second polygon that encloses all features of the second data; determine a larger polygon that encloses the first and second polygons; divide the larger polygon into first tiles; extract, from each of the first tiles overlaying the first data and from the each tile overlaying the second data, a first set of features and a second set of features, respectively; and identify, based on a computed disagreement level satisfying a set of criteria, each of one or more of the tiles. A set of identified tiles or all of the tiles may then be displayed, including shaded indicators overlaying features of respective portions of the first and second data.

Abstract: A system may be configured to collect geospatial features (in vector form) such that a software application is operable to edit an object represented by at least one vector. Some embodiments may: generate, via a trained machine learning model, a pixel map based on an aerial or satellite image; convert the pixel map into vector form; and store the vectors. This conversion may include a raster phase and a vector phase. A system may be configured to obtain another image, generate another pixel map based on the other image, convert the other pixel map into vector form, and compare the vectors to identify changes between the images. Some implementations may cause identification, based on a similarity with converted vectors, of a more trustworthy set of vectors for subsequent data source conflation.

Abstract: The invention provides thiazole derivatives of formula (I), or pharmaceutically acceptable salts thereof in which Ring A, R1, R2 and R3 are as defined in the specification; a processes for their preparation; pharmaceutical compositions containing them; and their use in therapy, for example in the treatment of disease mediated by a PI3K enzyme and/or a mTOR kinase.

Abstract: The present invention is an ultrasonic thrombectomy catheter that produces physical forces (shear rates) strong enough to emulsify obstructions such as thrombi and emboli without causing damage to arterial walls. This is accomplished by properly arranging piezoelectric transducers within a catheter and a tubular catheter head separated by a gap to generate acoustic streaming that simultaneously emulsifies the obstruction and sweeps resulting debris into a catheter lumen for removal. The open gap may be formed by supporting struts that connect the catheter to the catheter head. The design of the catheter tip allows the fabrication of catheters capable of removing partial or complete blockages from arteries and other vessels having diameters as small as 2 mm.

Abstract: The present invention provides a compound of a formula (I): wherein the variables are defined herein; to a process for preparing such a compound; and to the use of such a compound in the treatment of a PDE 4 mediated disease state.

Abstract: The use of compounds of formula (I) wherein R1, R3, R10, m and Ar are as defined in the Specification and pharmaceutically acceptable salts thereof in the manufacture of a medicament for the treatment or prophylaxis of diseases or conditions in which inhibition of kinase Itk activity is beneficial is disclosed.

Abstract: The invention provides thiazole derivatives of formula (I), or pharmaceutically acceptable salts thereof in which Ring A, R1, R2 and R3 are as defined in the specification; a processes for their preparation; pharmaceutical compositions containing them; and their use in therapy, for example in the treatment of disease mediated by a PI3K enzyme and/or a mTOR kinase.

Abstract: The present invention is an ultrasonic thrombectomy catheter that produces physical forces (shear rates) strong enough to emulsify obstructions such as thrombi and emboli without causing damage to arterial walls. This is accomplished by properly arranging piezoelectric transducers within a catheter and a tubular catheter head separated by a gap to generate acoustic streaming that simultaneously emulsifies the obstruction and sweeps resulting debris into a catheter lumen for removal. The open gap may be formed by supporting struts that connect the catheter to the catheter head. The design of the catheter tip allows the fabrication of catheters capable of removing partial or complete blockages from arteries and other vessels having diameters as small as 2 mm.

Abstract: The use of compounds of formula (I) wherein X, A, B, D, R1 and R2 are as defined in the Specification and pharmaceutically acceptable salts thereof in the manufacture of a medicament for the treatment or prophylaxis of diseases or conditions in which inhibition of kinase Itk activity is beneficial is disclosed. Certain novel compounds of formula (I), together with processes for their preparation, compositions containing them and their use in therapy are also disclosed.

Abstract: The use of compounds of formula (I) wherein R1, R3, R10, m and Ar are as defined in the Specification and pharmaceutically acceptable salts thereof in the manufacture of a medicament for the treatment or prophylaxis of diseases or conditions in which inhibition of kinase Itk activity is beneficial is disclosed. Certain novel compounds of formula (I), together with processes for their preparation, compositions containing them and their use in therapy are also disclosed.