Abstract: In order to damp shocks due to load alterations to as great an extent as possible, indexed base torque of the engine is determined which corresponds to a coupling torque able to be tapped off at the engine crankshaft and not reduced by engine loss torques. The indexed base torque is then converted by filtering into an indexed setpoint torque which exhibits a smaller rise compared to the indexed base torque in response to a load alteration. Finally, a setpoint ignition angle is derived from the an indexed setpoint torque.

Abstract: The invention is directed to a method for detecting combustion misfires in a multi-cylinder internal combustion engine, the method comprising the steps of: determining the rough-running values for the engine individual to the cylinders; determining a quantity for the level of a subset of the rough-running values; forming a reference value by logically coupling the quantity with an offset; and, comparing the rough-running values to the reference value and evaluating a passthrough of the reference value as a misfire.

Abstract: The present invention relates to a pharmaceutical composition comprising: (a) a compound of the formula ##STR1## wherein R.sup.1 and R.sup.2 are as defined below; and (b) isosorbide 5-mononitrate or isosorbide 2-mononitrate or glycerol trinitrate or glycerol 1-mononitrate or glycerol 2-mononitrate: and, optionally (c) a pharmaceutically acceptable carrier. The composition is useful in the prevention and treatment of cardiovascular diseases, and is especially useful in the prevention and treatment of angina pectoris and myocardial infarction.

Abstract: A method is described for the production of 6,12-dihydro-6-hydroxy-cannabidiol which is obtained by the reaction of olivetol and cis-p-menth-2-ene-1,8,-diol and the reaction thereof to yield trans-delta-9-tetrahydrocannabinol.

Abstract: Novel aminopropanol derivatives of 1,4:3,6-dianhydro-hexitol nitrates of the general formula I ##STR1## in which X has the meaning given in the specification, processes for their preparation and their use in preventing and treating angina pectoris, systemic hypertension and pulmonary hypertension in mammals.

Abstract: Oxime ethers of 2,6-dioxabicyclo[3.3.0]octanones of the formula I ##STR1## have pharmacological activity and are especially applicable as drugs for the prophylaxis and therapy of cardiac and circulatory diseases.

Abstract: Isohexide nucleosides of the formula I ##STR1## in which R and B have the meaning given in the description, processes for their preparation and their use as medicaments, in particular as cytostatics, virustatics and immunostimulants.

Abstract: Dianhydrohexites of the formula ##STR1## wherein R.sup.1 is hydrogen or benzyl, R.sub.2 is alkyl or omega-theophyllin-7-yl-alkyl, and R.sup.1 and R.sub.2 together with the nitrogen atom to which they are attached form a bicyclic group and R.sup.3 is hydrogen, acyl, pyridylcarbonyl, nitro or a hydroxylamino group, are formed by an analogous method and used as pharmaceuticals in the treatment of heart and circulatory diseases.

Abstract: The present invention relates to new acyl derivatives of 1,4:3,6-dianhydrohexitols, processes for their preparation and drugs containing the same. The new compounds have a cardiovascular effect and can be used as antihypertensive agents, as peripheral and central vasodilators and as coronary therapeutic agents.

Abstract: A process for the preparation of isosorbide-2-nitrate of the formula ##STR1## comprising contacting isosorbide with a carboxylic acid anhydride in the presence of a metal salt; esterifying the resultant isosorbide-5-acylate with nitric acid; and converting the resultant isosorbide-5-acylate-2-nitrate to isosorbide-2-nitrate by treatment with an alkyl alcohol in the presence of an alkali metal alcoholate.

Abstract: This invention relates to a process for the production of isosorbide-5-nitrate comprising(a) subjecting an acylation mixture of isosorbide containing varying proportions of isosorbide, isosorbide-2-acylate, isosorbide-5-acylate and/or isosorbide-2,5-diacylate, or pure isosorbide-5-acylate or an equimolar mixture of isosorbide-2,5-diacylate and isosorbide to a transacylation reaction in the presence of a catalyst and removing the isosorbide-2-acylate present from the reaction mixture by fractional distillation;(b) optionally subjecting the separated isosorbide-2-acylate to a further purification step;(c) esterifying the obtained isosorbide-2-acylate with nitric acid; and(d) partially hydrolyzing the obtained isosorbide-2-acylate-5-nitrate.

Abstract: Vincamine saccharinate, a novel derivative of vincamine, and pharmaceutical compositions containing vincamine saccharinate are disclosed. The solubility of vincamine saccharinate in glycerol-ethanol mixtures and the superior taste characteristics of vincamine saccharinate allow the preparation of preferred pharmaceutical compositions in solution form which are suitable for oral administration, especially in the form of drops.

Abstract: Sulphoximide derivatives of the general formula: ##STR1## wherein R.sub.1 is a phenyl, thienyl, furyl or pyridyl ring; R.sub.2 is a thienyl, furyl, or pyridyl ring; R.sub.3 and R.sub.4 are the same or are different and are alkyl groups containing up to 6 carbon atoms or together with the nitrogen atom to which they are attached form a pyrrolidine, piperidine, or morpholine ring; and n is a whole number from 1 to 5; and the pharmaceutically acceptable organic and inorganic acid addition and quaternary ammoniuim salts thereof. The compounds of the invention exhibit anti-bronchospasmolytic activity.

Abstract: The present invention is concerned with novel tricyclic sulphoximides and with the preparation thereof. This family of compounds has been found to possess antihistaminic, antitussive, antiinflammatory, sedative, and diuretic properties.

Abstract: The present invention is concerned with novel tricyclic sulphoximides and with the preparation thereof. This family of compounds has been found to possess antihistaminic, antitussive, antiinflammatory, sedative, and diuretic properties.

Abstract: The present invention is concerned with novel tricyclic sulphoximides and with the preparation thereof. This family of compounds has been found to possess antihistominic, antitussive, antiinflammatory, sedative, and diuretic properties.

Abstract: The present invention is concerned with novel tricyclic sulphoximides and with the preparation thereof. This family of compounds has been found to possess antihistominic, antitussive, antiinflammatory, sedative, and diuretic properties.

Abstract: The present invention is concerned with novel tricyclic sulphoximides and with the preparation thereof. This family of compounds has been found to possess antihistaminic, antitussive, antiinflammatory, sedative, and diuretic properties.

Abstract: The present invention is concerned with tricyclic sulphoximides and with the preparation thereof. This family of compounds has been found to possess antihistominic, antitussive, antiinflammatory, sedative, and diuretic properties.

Abstract: The present invention is concerned with new cyclic sulphoximide derivatives with valuable pharmacological properties and with the preparation thereof.