Abstract: A method for the treatment of cancer by administering a therapeutically effective amount of a cyclin-dependent kinase (CDK) inhibitor with a therapeutically effective amount of a B cell chronic lymphocytic leukemia/lymphoma 2 inhibitor (“B Cell CLL/Lymphoma 2”, or “BCL-2”). Administration of the CDK inhibitor and BCL-2 inhibitor can be simultaneous, successive or separate.

Abstract: A method for the treatment of cancer by administering a therapeutically effective amount of a cyclin-dependent kinase (CDK) inhibitor with a therapeutically effective amount of a B cell chronic lymphocytic leukemia/lymphoma 2 inhibitor (“B Cell CLL/Lymphoma 2”, or “BCL-2”). Administration of the CDK inhibitor and BCL-2 inhibitor can be simultaneous, successive or separate.

Abstract: An elevation measuring device comprises a measuring column at which a vertically movable measuring slide is supported, so it can be moved by hand and also by a drive motor through a clutch device. The measuring slide supports a scan head, which imparts a constant measuring force onto the measuring location at the work piece, which is generated by the drive motor and the clutch device. A measuring system detects the elevation coordinate of the scan head and hands said elevation coordinate to a control device for further processing and evaluation. The control device comprises logic for automating the measuring process. This logic automatically detects a positioning of the scan head in a certain direction, which is manually performed by the operator, subsequently controls the drive motor in a suitable manner in order to cause a scanning of the work piece and determines the measurement values.

Abstract: The invention relates to the identification and use of gene expression profiles with clinical relevance to the treatment of cellular proliferative disorders, especially those mediated by aberrant Notch signaling using a Notch signaling inhibitor. In particular, the invention provides the identities of genes, whose individual or cumulative expression patterns may be useful in various assays. The gene expression profiles, whether embodied in nucleic acid expression, protein expression, or other expression formats, may be used to select subjects afflicted with a Notch mediated cancer who will likely respond to treatment with a gamma-secretase inhibitor or another Notch inhibiting agent. The same markers may be used in the classification of patients being treated with other Notch inhibitors. The methods may further comprise providing diagnostic, prognostic, or predictive information based on the classifying step. The methods may further comprise selecting a treatment based on the classifying step.

Abstract: An elevation measuring device (1) comprises a measuring column (3) at which a vertically movable measuring slide (4) is supported, so it can be moved by hand and also by a drive motor (14) through a clutch device (15). The measuring slide (4) supports a scan head (8), which imparts a constant measuring force onto the measuring location at the work piece, which is generated by the drive motor (14) and the clutch device (15). A measuring system (19) detects the elevation coordinate of the scan head (8) and hands said elevation coordinate to a control device (21) for further processing and evaluation. The control device (21) comprises logic (33) for automating the measuring process.

Abstract: A distance measuring system (1) is provided with a capacitive sensor (7a, 7b), designed in the form of a differential capacitor (18), for which the partial capacitors (C1, C2 have capacitances that depend on the position to be determined. The system also includes a processing device (5) for determining the desired distance that contains, for example, a sigma/delta demodulator. The partial capacitors (C1, C2) are triggered periodically with binary signals, wherein the trigger signals from the one partial capacitor (C1) are transmitted with a phase offset to the signals from the other partial capacitor (C2). The processing device (5) determines which trigger signals must be used for the evaluation. Within time windows that are synchronized with the edges of the trigger signals, a switch unit (22) allows the associated receiving signals to pass through to the processing unit (5) and blanks out all other signals.

Abstract: A distance measuring system (1) is provided with a capacitive sensor (7a, 7b), designed in the form of a differential capacitor (18), for which the partial capacitors (C1, C2 have capacitances that depend on the position to be determined. The system also comprises a processing device (5) for determining the desired distance that contains, for example, a sigma/delta demodulator. The partial capacitors (C1, C2) are triggered periodically with binary signals, wherein the trigger signals from the one partial capacitor (C1) are transmitted with a phase offset to the signals from the other partial capacitor (C2). The processing device (5) determines which trigger signals must be used for the evaluation. Within time windows that are synchronized with the edges of the trigger signals, a switch unit (22) allows the associated receiving signals to pass through to the processing unit (5) and blanks out all other signals.

Abstract: A capacitive measuring device or apparatus; in particular, a length-measuring apparatus, which incorporates a scale portion and a scanning unit which is movable relative to the former and which supports transmitting electrodes and at least one receiving electrode. Herein, a transmission circuit applies transmitting signals at a basic frequency to the transmitting electrodes, and with the receiving electrode being connected to a reception circuit, to the output side of which there is connected an evaluating circuit for the receiving signals. The transmitting signals are applied to the transmitting electrodes through a pulse width modulator and a synchronous modulator and the receiving signal is conducted through a demodulator.