Patents by Inventor Peter Strop

Peter Strop has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7122323
    Abstract: An apparatus and method for synthesizing a combinatorial library comprising a plurality of chemical compounds such that the chemical composition of each compound is easily tracked. The library compounds are synthesized on solid-phase supports, which are spatially arranged in frames during synthesis according to a predetermined protocol, such that each solid-phase support passes through a series of unique spatial 2D or 3D addresses by which the chemical composition of each compound may be determined at any point during synthesis. Solid-phase supports include hollow tubular-shaped lanterns and gears.
    Type: Grant
    Filed: December 11, 2002
    Date of Patent: October 17, 2006
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: Marcel Patek, Safar Pavel, Martin Smrcina, Eric Wegrzyniak, Peter Strop, Gary A Flynn, Stephen A Baum
  • Patent number: 6759384
    Abstract: The invention provides compounds which specifically inhibit factor Xa activity having the structure A1—A2—(A3)m—B, where m is 0 or 1. A compound of the invention is characterized, in part, in that it exhibits a specific inhibition of factor Xa activity with a Ki≦100 &mgr;M, preferably ≦2 nM, and does not substantially inhibit the activity of other proteases involved in the coagulation cascade. The invention further provides methods of specifically inhibiting the activity of factor Xa and of inhibiting blood clotting in vitro and in an individual and methods of detecting factor Xa levels or activity.
    Type: Grant
    Filed: December 14, 1998
    Date of Patent: July 6, 2004
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: Fahad Al-Obeidi, Michal Lebl, James A. Ostrem, Pavel Safar, Alena Stierandova, Peter Strop, Armin Walser
  • Patent number: 6750448
    Abstract: The present invention provides an instrument and methods for the preparative separation of components of mixtures using mass spectrometric methods. Nondestructive ionization methods are employed to generate ionized components of a mixture, the ionized components are spatially separated by mass and the mass-separated ion components are trapped. The ion source and mass spectrometric techniques employed allow the generation of large ion currents of ion components, on the order of nanoamps, which facilitate rapid accumulation of nanomole quantities of mass-separated components in relatively short times (minutes to hours).
    Type: Grant
    Filed: March 10, 2003
    Date of Patent: June 15, 2004
    Assignees: University of Washington, Aventis Pharmaceuticals, Inc.
    Inventors: Frantisek Turecek, Adi Scheidemann, Terry Olney, Frank J. Schumacher, Martin Smrcina, Peter Strop, Marcel Patek, Daniel Schirlin
  • Publication number: 20030198999
    Abstract: An apparatus and method for synthesizing a combinatorial library comprising a plurality of chemical compounds such that the chemical composition of each compound is easily tracked. The library compounds are synthesized on solid-phase supports, which are spatially arranged in frames during synthesis according to a predetermined protocol, such that each solid-phase support passes through a series of unique spatial 2D or 3D addresses by which the chemical composition of each compound may be determined at any point during synthesis. Solid-phase supports include hollow tubular-shaped lanterns and gears.
    Type: Application
    Filed: December 11, 2002
    Publication date: October 23, 2003
    Applicant: Selecticide Corporation
    Inventors: Marcel Patek, Safar Pavel, Martin Smrcina, Eric Wegrzyniak, Peter Strop, Gary A. Flynn, Stephen A. Baum
  • Publication number: 20030197121
    Abstract: The present invention provides an instrument and methods for the preparative separation of components of mixtures using mass spectrometric methods. Nondestructive ionization methods are employed to generate ionized components of a mixture, the ionized components are spatially separated by mass and the mass-separated ion components are trapped. The ion source and mass spectrometric techniques employed allow the generation of large ion currents of ion components, on the order of nanoamps, which facilitate rapid accumulation of nanomole quantities of mass-separated components in relatively short times (minutes to hours).
    Type: Application
    Filed: March 10, 2003
    Publication date: October 23, 2003
    Inventors: Frantisek Turecek, Adi Scheidemann, Terry Olney, Frank J. Schumacher, Martin Smrcina, Peter Strop, Marcel Patek, Daniel Schirlin
  • Publication number: 20030143630
    Abstract: An apparatus and method for synthesizing a combinatorial library comprising a plurality of chemical compounds such that the chemical composition of each compound is easily tracked. The library compounds are synthesized on solid-phase supports, which are spatially arranged in frames during synthesis according to a predetermined protocol, such that each solid-phase support passes through a series of unique spatial 2D or 3D addresses by which the chemical composition of each compound may be determined at any point during synthesis. Solid-phase supports include hollow tubular-shaped lanterns and gears.
    Type: Application
    Filed: December 11, 2002
    Publication date: July 31, 2003
    Applicant: Selecticide Corporation
    Inventors: Marcel Patek, Safar Pavel, Martin Smrcina, Eric Wegrzyniak, Peter Strop, Gary A. Flynn, Stephen A. Baum
  • Patent number: 6541211
    Abstract: An apparatus and method for synthesizing a combinatorial library comprising a plurality of chemical compounds such that the chemical composition of each compound is easily tracked. The library compounds are synthesized on solid-phase supports, which are spatially arranged in frames during synthesis according to a predetermined protocol, such that each solid-phase support passes through a series of unique spatial 2D or 3D addresses by which the chemical composition of each compound may be determined at any point during synthesis. Solid-phase supports include hollow tubular-shaped lanterns and gears.
    Type: Grant
    Filed: November 24, 1999
    Date of Patent: April 1, 2003
    Assignee: Selectide Corporation
    Inventors: Marcel Patek, Safar Pavel, Martin Smrcina, Eric Wegrzyniak, Peter Strop, Gary A. Flynn, Stephen A. Baum
  • Patent number: 5849510
    Abstract: The invention provides compounds which specifically inhibit factor Xa activity. The compounds consist of the structure X.sub.1 -YIR-X.sub.2, wherein X.sub.1 is H, acyl, alkyl, acylalkyl, arylalkyl or one or more amino acids, and X.sub.2 is a modified C-terminal group, one or more carboxy-protecting groups or one or more amino acids or other substituent, and Y, I and R are tyrosine, isoleucine and arginine, respectively, or peptidomimetic or organic structures that possess the same functional activity as Y, I and R, respectively. In addition, the present invention provides a compound having the structure A1-A2-(A3).sub.m --B, where m is 0 or 1. A compound of the invention can be linear or cyclic and can be about 2 and 43 residues in length. A compound of the invention is characterized, in part, in that it exhibits a specific inhibition of factor Xa activity with a K.sub.i of .ltoreq.100 .mu.M, preferably .ltoreq.
    Type: Grant
    Filed: October 8, 1997
    Date of Patent: December 15, 1998
    Assignee: Selectide Corporation
    Inventors: Fahad Al-Obeidi, Michal Lebl, James A. Ostrem, Pavel Safar, Alena Stierandova, Peter Strop, Armin Walser