Abstract: Disclosed herein are methods and uses of the polypharmacological modulator SR1903 and related compounds for inhibiting triggering receptor expressed on myeloid cells-1 (TREM-1) and treating diseases and conditions that are related to or mediated by TREM-1, such as inflammatory diseases, autoimmune diseases, metabolic disorders, and castration resistant prostate cancer (CRPC).

Abstract: Systems and methods for diagnosis or treating tinnitus are disclosed. In some embodiments, a method for treating tinnitus includes receiving, by a programmed computer system, input data representative of one or more of the following characteristics of an user tinnitus: central frequency, bandwidth, volume, hearing threshold, and tone to noise ratio of a user tinnitus; processing, in real-time, by the programmed computer system, user tinnitus data to generate a user tinnitus profile based on the received one or more categories of user tinnitus data; and generating, in real-time, by the programmed computer system, a notched audio output according to the user tinnitus profile.