Patents by Inventor Peter Syapin

Peter Syapin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modified Tetracycline for Treatment of Alcohol Use Disorder, Pain and Other Disorders Involving Potential Inflammatory Processes
    Publication number: 20250129014
    Abstract: A method of treating Alcohol Use Disorder (AUD), Substance Use Disorder (SUD), tobacco use, pain, or proinflammatory disorders comprising: providing a subject with an effective amount of a modified tetracycline or derivative thereof to ameliorate or eliminate the AUD, SUD, tobacco use, pain, or proinflammatory disorder, and wherein the modified tetracycline or derivative thereof has reduced binding to a microbial ribosome and has the formula: wherein R1 is acetyl, R2 is OH or acetyl, R3 is acetyl, R4 is H or acetyl, and R5 is acetyl.
    Type: Application
    Filed: December 10, 2024
    Publication date: April 24, 2025
    Inventors: Susan E. Bergeson, Peter Syapin, Ted W. Reid, Mayank Shashtri, Phat Tran
  • Modified tetracycline for treatment of alcohol use disorder, pain and other disorders involving potential inflammatory processes
    Patent number: 12202785
    Abstract: A method of treating Alcohol Use Disorder (AUD), Substance Use Disorder (SUD), tobacco use, pain, or proinflammatory disorders comprising: providing a subject with an effective amount of a modified tetracycline or derivative thereof to ameliorate or eliminate the AUD, SUD, tobacco use, pain, or proinflammatory disorder, and wherein the modified tetracycline or derivative thereof has reduced binding to a microbial ribosome and has the formula: wherein R1 is acetyl, R2 is OH or acetyl, R3 is acetyl, R4 is H or acetyl, and R5 is acetyl.
    Type: Grant
    Filed: November 29, 2022
    Date of Patent: January 21, 2025
    Assignee: TEXAS TECH UNIVERSITY SYSTEM
    Inventors: Susan E. Bergeson, Peter Syapin, Ted W. Reid, Mayank Shastri, Phat Tran
  • NOVEL MODIFIED TETRACYCLINES FOR TREATMENT OF ALCOHOL USE DISORDER, PAIN AND OTHER DISORDERS INVOLVING POTENTIAL INFLAMMATORY PROCESSES
    Publication number: 20230192598
    Abstract: The present invention includes novel molecules and methods for using the same to treat Alcohol Use Disorder (AUD), Substance Use Disorder (SUD), tobacco use, pain, or proinflammatory disorders comprising a modified tetracycline molecule, pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, and tautomers thereof comprise: a Deamino Diacetyl Minocycline, hyl Ether Minocycline, Ethyl Ether Minocycline, Propyl Ether Minocycline, Butyl Ether Minocycline, Butyl Ether Monoacetyl Minocycline, Butyl Ether Diacetyl Minocycline, Buty Ether Triacetyl Minocycline, or Butyl Ether Tetra Acetyl Minocycline.
    Type: Application
    Filed: March 10, 2021
    Publication date: June 22, 2023
    Inventors: Susan Bergeson, Peter Syapin, Ted W. Reid, Mayank Shashtri, Phat L. Tran
  • Modified Tetracycline for Treatment of Alcohol Use Disorder, Pain and Other Disorders Involving Potential Inflammatory Processes
    Publication number: 20230127462
    Abstract: A method of treating Alcohol Use Disorder (AUD), Substance Use Disorder (SUD), tobacco use, pain, or proinflammatory disorders comprising: providing a subject with an effective amount of a modified tetracycline or derivative thereof to ameliorate or eliminate the AUD, SUD, tobacco use, pain, or proinflammatory disorder, and wherein the modified tetracycline or derivative thereof has reduced binding to a microbial ribosome and has the formula: wherein R1 is acetyl, R2 is OH or acetyl, R3 is acetyl, R4 is H or acetyl, and R5 is acetyl.
    Type: Application
    Filed: November 29, 2022
    Publication date: April 27, 2023
    Inventors: Susan E. Bergeson, Peter Syapin, Ted W. Reid, Mayank Shastri, Phat Tran
  • Modified tetracycline for treatment of alcohol use disorder, pain and other disorders involving potential inflammatory processes
    Patent number: 11542227
    Abstract: A method of treating Alcohol Use Disorder (AUD), Substance Use Disorder (SUD), tobacco use, pain, or proinflammatory disorders comprising: providing a subject with an effective amount of a modified tetracycline or derivative thereof to ameliorate or eliminate the AUD, SUD, tobacco use, pain, or proinflammatory disorder, and wherein the modified tetracycline or derivative thereof has reduced binding to a microbial ribosome and has the formula wherein R1 is acetyl, R2 is OH or acetyl, R3 is acetyl, R4 is H or acetyl, and R5 is acetyl.
    Type: Grant
    Filed: June 13, 2019
    Date of Patent: January 3, 2023
    Assignee: Texas Tech University System
    Inventors: Susan E. Bergeson, Peter Syapin, Ted W. Reid, Mayank Shashtri, Phat Tran
  • Modified Tetracycline for Treatment of Alcohol Use Disorder, Pain and Other Disorders Involving Potential Inflammatory Processes
    Publication number: 20220040208
    Abstract: A method of treating Alcohol Use Disorder (AUD), Substance Use Disorder (SUD), tobacco use, pain, or proinflammatory disorders comprising: providing a subject with an effective amount of a modified tetracycline or derivative thereof to ameliorate or eliminate the AUD, SUD, tobacco use, pain, or proinflammatory disorder, and wherein the modified tetracycline or derivative thereof has reduced binding to a microbial ribosome and has the formula wherein R1 is acetyl, R2 is OH or acetyl, R3 is acetyl, R4 is H or acetyl, and R5 is acetyl.
    Type: Application
    Filed: June 13, 2019
    Publication date: February 10, 2022
    Inventors: Susan E. Bergeson, Peter Syapin, Ted W. Reid, Mayank Shashtrl, Phat Tran
  • Novel Modified Tetracyclines for Treatment of Alcohol Use Disorder, Pain and Other Disorders Involving Potential Inflammatory Processes
    Publication number: 20210403416
    Abstract: The present invention includes novel molecules and methods for using the same to treat Alcohol Use Disorder (AUD), Substance Use Disorder (SUD), tobacco use, pain, or proinflammatory disorders comprising: identifying a subject in need of treatment for at least one of AUD, SUD, pain, or a proinflammatory disorder; and providing the subject with an effective amount of a modified minocycline to ameliorate or eliminate the AUD, SUD, pain, or proinflammatory disorder and that has reduced, or no, antimicrobial activity, wherein the modified tetracycline has a formula, e.g., or the modified doxycycline, minocycline, and tigecycline and their tautomerized structures, where the R-groups shown in the minocycline example above could be different combination of halogen, acetyl ester, methyl ester, and diacetal.
    Type: Application
    Filed: June 13, 2019
    Publication date: December 30, 2021
    Inventors: Susan E. Bergeson, Ted W. Reid, Mayank Shashtri, Peter Syapin, Phat Tran