Abstract: Provided here are non-invasive methods for evaluating functional connectivity patterns in localized brain regions of a patient involving application of a MS-specific functional meta-analytic connectivity model in resting-state functional magnetic resonance imaging (rsfMRI) data to provide patients with appropriate medical care in response to output from the model.

Abstract: Various implementations include a device for locating a position in a body. The device includes a first body portion. The first body portion has a first longitudinal axis. The device includes a second body portion. The second body portion is slidably coupled to the first body portion. The second body portion has a second longitudinal axis. The device includes a first set of markers disposed on the first body portion for measuring along the first longitudinal axis. The first set of markers includes at least two radiopaque markers. The device also includes a second set of markers disposed on the second body portion for measuring along the second longitudinal axis. The second set of markers includes at least two radiopaque markers. The first body portion is slidable along the second longitudinal axis. The second body portion is slidable along the first longitudinal axis.

Abstract: Transcranial magnetic stimulation may be delivered to a subject based on a treatment plan. This treatment plan is generated using connectivity-image guidance to identify one or more optimal locations to stimulate based on network properties. In turn, a cortical column cosine principle may be applied to identify one or more particular subject locations at which to deliver TMS to the subject to the optimal locations.

Abstract: Various implementations include a device for locating a position in a body. The device includes a first body portion. The first body portion has a first longitudinal axis. The device includes a second body portion. The second body portion is slidably coupled to the first body portion. The second body portion has a second longitudinal axis. The device includes a first set of markers disposed on the first body portion for measuring along the first longitudinal axis. The first set of markers includes at least two radiopaque markers. The device also includes a second set of markers disposed on the second body portion for measuring along the second longitudinal axis. The second set of markers includes at least two radiopaque markers. The first body portion is slidable along the second longitudinal axis. The second body portion is slidable along the first longitudinal axis.

Abstract: Transcranial magnetic stimulation may be delivered to a subject based on a treatment plan. This treatment plan is generated using connectivity-image guidance to identify one or more optimal locations to stimulate based on network properties. In turn, a cortical column cosine principle may be applied to identify one or more particular subject locations at which to deliver TMS to the subject to the optimal locations.

Abstract: Disclosed are apparatus and methods for computer-aided, robotic delivery of transcranial magnetic stimulation (TMS) using biologically derived feedback to establish coil position relative to brain functional regions. The apparatus includes a TMS coil mounted to a robotic member. The position of the stimulating coil can be automatically optimized using the TMS-induced bio-responses of various types.

Abstract: Disclosed are apparatus and methods for computer-aided, robotic delivery of transcranial magnetic stimulation (TMS) using biologically derived feedback to establish coil position relative to brain functional regions. The apparatus includes a TMS coil mounted to a robotic member. The position of the stimulating coil can be automatically optimized using the TMS-induced bio-responses of various types.

Abstract: In one embodiment, the present invention includes a method for performing magnetic resonance imaging on a subject and directly mapping electromagnetic activity of neural firing of the subject via the magnetic resonance imaging.

Abstract: In one embodiment, the present invention includes a method for performing magnetic resonance imaging on a subject and directly mapping electromagnetic activity of neural firing of the subject via the magnetic resonance imaging.