Patents by Inventor Peter T. Sage

Peter T. Sage has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR MODULATING AN IMMUNE RESPONSE
    Publication number: 20220010275
    Abstract: The invention provides methods of modulating follicular regulatory T (TFR) cell-mediated immune responses and the use of those methods in the treatment of diseases or conditions such as viral, bacterial, pathogenic, or fungal infections or cancer. Such methods provide for boosting of antibody production through the use of IL-21 to overcome TFR cell suppression of antibody production.
    Type: Application
    Filed: May 7, 2021
    Publication date: January 13, 2022
    Inventors: Arlene H. Sharpe, Peter T. Sage
  • Regulatory T cell PD-1 modulation for regulating T cell effector immune responses
    Patent number: 11207393
    Abstract: The present invention is based, in part, on the identification of methods of modulating PD-1 expression and/or activity in regulatory T cells (Tregs) to thereby regulate effector immune responses in effector T cells (Teffs).
    Type: Grant
    Filed: October 14, 2016
    Date of Patent: December 28, 2021
    Assignees: President and Fellows of Harvard College, The Brigham and Women's Hospital, Inc., Dana-Farber Cancer Institute, Inc.
    Inventors: Arlene H. Sharpe, Gordon J. Freeman, Loise M. Francisco, Peter T. Sage, Sun J. Lee, Scott B. Lovitch, Vikram R. Juneja, Catherine L. Tan
  • Compositions and methods for modulating an immune response
    Patent number: 11028364
    Abstract: The invention provides methods of modulating follicular regulatory T (TFR) cell-mediated immune responses and the use of those methods in the treatment of diseases or conditions such as viral, bacterial, pathogenic, or fungal infections or cancer. Such methods provide for boosting of antibody production through the use of IL-21 to overcome TFR cell suppression of antibody production.
    Type: Grant
    Filed: November 23, 2016
    Date of Patent: June 8, 2021
    Assignee: President and Fellows of Harvard College
    Inventors: Peter T. Sage, Arlene H. Sharpe
  • Compositions and methods for modulating an immune response
    Patent number: 10577586
    Abstract: The invention provides methods of modulating follicular regulatory T (TFR) cell-mediated immune responses, follicular helper T (TFH) cell-mediated immune responses or both, and the use of those methods in the treatment of diseases or conditions mediated by TFR or TFH cells. The invention also provides novel methods for identifying TFR and TFH cells in a population of cells. The invention also provides compositions comprising TFR cells that have enhanced suppressive activity as compared wild type TFR cells. The invention also provides compositions comprising T follicular regulatory (TFR) cells isolated from the peripheral blood of a subject wherein the composition is enriched for TFR cells. Methods of making and using the compositions of the invention to modulate an immune response are also provided.
    Type: Grant
    Filed: February 5, 2018
    Date of Patent: March 3, 2020
    Assignee: President and Fellows of Harvard College
    Inventors: Arlene H. Sharpe, Peter T. Sage, Loise M. Francisco
  • COMPOSITIONS AND METHODS FOR MODULATING AN IMMUNE RESPONSE
    Publication number: 20180340147
    Abstract: The invention provides methods of modulating follicular regulatory T (TFR) cell-mediated immune responses and the use of those methods in the treatment of diseases or conditions such as viral, bacterial, pathogenic, or fungal infections or cancer. Such methods provide for boosting of antibody production through the use of IL-21 to overcome TFR cell suppression of antibody production.
    Type: Application
    Filed: November 23, 2016
    Publication date: November 29, 2018
    Inventors: Peter T. Sage, Arlene H. Sharpe
  • REGULATORY T CELL PD-1 MODULATION FOR REGULATING T CELL EFFECTOR IMMUNE RESPONSES
    Publication number: 20180303922
    Abstract: The present invention is based, in part, on the identification of methods of modulating PD-1 expression and/or activity in regulatory T cells (Tregs) to thereby regulate effector immune responses in effector T cells (Teffs).
    Type: Application
    Filed: October 14, 2016
    Publication date: October 25, 2018
    Inventors: Arlene H. Sharpe, Gordon J. Freeman, Loise M. Francisco, Peter T. Sage, Sun J. Lee, Scott B. Lovitch, Vikram R. Juneja, Catherine L. Tan
  • Compositions and Methods for Modulating an Immune Response
    Publication number: 20180230428
    Abstract: The invention provides methods of modulating follicular regulatory T (TFR) cell-mediated immune responses, follicular helper T (TFH) cell-mediated immune responses or both, and the use of those methods in the treatment of diseases or conditions mediated by TFR or TFH cells. The invention also provides novel methods for identifying TFR and TFH cells in a population of cells. The invention also provides compositions comprising TFR cells that have enhanced suppressive activity as compared wild type TFR cells. The invention also provides compositions comprising T follicular regulatory (TFR) cells isolated from the peripheral blood of a subject wherein the composition is enriched for TFR cells. Methods of making and using the compositions of the invention to modulate an immune response are also provided.
    Type: Application
    Filed: February 5, 2018
    Publication date: August 16, 2018
    Inventors: Arlene H. Sharpe, Peter T. Sage, Loise M. Francisco
  • Compositions and methods for modulating an immune response
    Patent number: 9885016
    Abstract: The invention provides methods of modulating follicular regulatory T (TFR) cell-mediated immune responses, follicular helper T (TFH) cell-mediated immune responses or both, and the use of those methods in the treatment of diseases or conditions mediated by TFR or TFH cells. The invention also provides novel methods for identifying TFR and TFH cells in a population of cells. The invention also provides compositions comprising TFR cells that have enhanced suppressive activity as compared wild type TFR cells. The invention also provides compositions comprising T follicular regulatory (TFR) cells isolated from the peripheral blood of a subject wherein the composition is enriched for TFR cells. Methods of making and using the compositions of the invention to modulate an immune response are also provided.
    Type: Grant
    Filed: May 8, 2015
    Date of Patent: February 6, 2018
    Assignee: President and Fellows of Harvard College
    Inventors: Arlene H. Sharpe, Peter T. Sage, Loise M. Francisco
  • Compositions and Methods for Modulating an Immune Response
    Publication number: 20160032245
    Abstract: The invention provides methods of modulating follicular regulatory T (TFR) cell-mediated immune responses, follicular helper T (TFH) cell-mediated immune responses or both, and the use of those methods in the treatment of diseases or conditions mediated by TFR or TFH cells. The invention also provides novel methods for identifying TFR and TFH cells in a population of cells. The invention also provides compositions comprising TFR cells that have enhanced suppressive activity as compared wild type TFR cells. The invention also provides compositions comprising T follicular regulatory (TFR) cells isolated from the peripheral blood of a subject wherein the composition is enriched for TFR cells. Methods of making and using the compositions of the invention to modulate an immune response are also provided.
    Type: Application
    Filed: May 8, 2015
    Publication date: February 4, 2016
    Inventors: Arlene H. Sharpe, Peter T. Sage, Loise M. Francisco