Abstract: An interventional device for delivery of beneficial agent to a lumen and methods of loading and manufacture of the same, which include a prosthesis loaded with beneficial agent to provide a controlled dosage concentration of beneficial agent to the lumen. The beneficial agent is loaded onto the prosthesis by a fluid-dispenser having a dispensing element capable of dispensing the beneficial agent in discrete droplets, each droplet having a controlled trajectory. The interventional device has a controlled local areal density of beneficial agent for systemic delivery or delivery to the luminal wall. The local areal density of beneficial agent may be varied along the prosthesis. The interventional device includes overlapping or bifurcated stents having a controlled areal density of beneficial agent.

Abstract: A method of making a medical device which is at least partially bio-erodible and which exhibits controlled elution of therapeutic agent.

Abstract: A medical device which is at least partially bio-erodible and which exhibits controlled elution of therapeutic agent.

Abstract: A beneficial agent can be loaded as discrete droplets on a prosthesis, such as a stent. Relative movement between the prosthesis and a dispensing element can be controlled to define a dispensing path in a raster format. The discrete droplets can be dispensed from a dispensing element when the dispensing element is detected to be in alignment with a cavity formed in the prosthesis such that the discrete droplets are deposited in the cavity. The discrete droplets can be dispensed from a dispensing element when the dispensing element is detected to be in alignment with a structural element of the prosthesis such that the discrete droplets are deposited on the structural element.

Abstract: An interventional device for delivery of beneficial agent to a lumen and methods of loading and manufacture of the same, which include a prosthesis loaded with beneficial agent to provide a controlled dosage concentration of beneficial agent to the lumen. The beneficial agent is loaded onto the prosthesis by a fluid-dispenser having a dispensing element capable of dispensing the beneficial agent in discrete droplets, each droplet having a controlled trajectory. The method of loading beneficial agent includes dispensing beneficial agent in a raster format and/or an off-axis format along a dispensing path.

Abstract: An interventional device for delivery of beneficial agent to a lumen and methods of loading and manufacture of the same, which include a prosthesis loaded with beneficial agent to provide a controlled dosage concentration of beneficial agent to the lumen. The beneficial agent is loaded onto the prosthesis by a fluid-dispenser having a dispensing element capable of dispensing the beneficial agent in discrete droplets, each droplet having a controlled trajectory. The method of loading beneficial agent includes dispensing beneficial agent in a raster format and/or an off-axis format along a dispensing path.

Abstract: An interventional device for delivery of beneficial agent to a lumen and methods of loading and manufacture of the same, which include a prosthesis loaded with beneficial agent to provide a controlled dosage concentration of beneficial agent to the lumen. The beneficial agent is loaded onto the prosthesis by a fluid-dispenser having a dispensing element capable of dispensing the beneficial agent in discrete droplets, each droplet having a controlled trajectory. The method of loading beneficial agent includes dispensing beneficial agent in a raster format and/or an off-axis format along a dispensing path.

Abstract: An interventional device for delivery of beneficial agent to a lumen and methods of loading and manufacture of the same, which include a prosthesis loaded with beneficial agent to provide a controlled dosage concentration of beneficial agent to the lumen. The beneficial agent is loaded onto the prosthesis by a fluid-dispenser having a dispensing element capable of dispensing the beneficial agent in discrete droplets, each droplet having a controlled trajectory. The method of loading beneficial agent includes dispensing beneficial agent in a raster format and/or an off-axis format along a dispensing path.

Abstract: The present disclosure relates, according to some embodiments, to devices, systems, and/or methods for delivery (e.g., controlled delivery) of a pharmaceutical to a subject's spine. For example, the disclosure relates to implants that provide both a mechanical function and a pharmacological function. According to some embodiments, a spinal implant may comprise a rigid spinal implant body having one or more recesses, one or more layers in each of the one or more recesses, each of the one or more layers comprising a biocompatible material and a pharmaceutically effective amount of a pharmaceutical compound; and at least one biocompatible cap in each of the one or more recesses. An implant may further comprise biocompatible barriers interspersed between the layers.

Abstract: The present disclosure relates, according to some embodiments, to compositions, devices, systems, and methods for inhibiting an inflammatory response (e.g., an inflammatory response associated with spinal surgery). For example, some embodiments of the present disclosure may reduce and/or eliminate an inflammatory response associated with friction between a soft tissue and an implant and/or between a soft tissue and a hard tissue.

Abstract: The present invention provides a unique non-viral carrier for nucleic acid delivery in vitro and in vivo, and methods of using thereof.

Abstract: Some embodiments of the present disclosure relate to an implantable device for the closure and/or repair of a spinal defect (e.g., posterior annular defects) and/or preventing recurring herniation. An implantable medical device, in some embodiments, may be coated or impregnated with a releasable pharmaceutical compound. Accordingly, some embodiments of the present disclosure relate to compositions that include one or more pharmaceutical compounds. In addition, some embodiments of the disclosure relate to methods for making and using compositions and medical implants. A spinal implant may include, for example, a scaffold having a substantially planar surface; and a plurality of tails, each of which has a first end that is attached to the scaffold and a second end that is configured and arranged to be threaded through a respective perforation in a vertical body, wherein the scaffold comprises a pharmaceutically effective amount of a pharmaceutical agent.

Abstract: An interventional device for delivery of beneficial agent to a lumen and methods of loading and manufacture of the same, which include a prosthesis loaded with beneficial agent to provide a controlled dosage concentration of beneficial agent to the lumen. The beneficial agent is loaded onto the prosthesis by a fluid-dispenser having a dispensing element capable of dispensing the beneficial agent in discrete droplets, each droplet having a controlled trajectory. The method of loading beneficial agent includes dispensing beneficial agent in a raster format and/or an off-axis format along a dispensing path.

Abstract: The present invention provides a unique non-viral carrier for nucleic acid delivery in vitro and in vivo, and methods of using thereof.

Abstract: A method of making a medical device which is at least partially bio-erodible and which exhibits controlled elution of therapeutic agent.

Abstract: A medical device which is at least partially bio-erodible and which exhibits controlled elution of therapeutic agent.

Abstract: An interventional device for delivery of beneficial agent to a lumen and methods of loading and manufacture of the same, which include a prosthesis loaded with beneficial agent to provide a controlled dosage concentration of beneficial agent to the lumen. The beneficial agent is loaded onto the prosthesis by a fluid-dispenser having a dispensing element capable of dispensing the beneficial agent in discrete droplets, each droplet having a controlled trajectory. The method of loading beneficial agent includes dispensing beneficial agent in a raster format and/or an off-axis format along a dispensing path.

Abstract: An interventional device for delivery of beneficial agent to a lumen and methods of loading and manufacture of the same, which include a prosthesis loaded with beneficial agent to provide a controlled dosage concentration of beneficial agent to the lumen. The beneficial agent is loaded onto the prosthesis by a fluid-dispenser having a dispensing element capable of dispensing the beneficial agent in discrete droplets, each droplet having a controlled trajectory. The method of loading beneficial agent includes dispensing beneficial agent in a raster format and/or an off-axis format along a dispensing path.

Abstract: A medical device comprising a supporting structure having a coating on the surface thereof, the coating containing a therapeutic substance, such as, for example, a drug. Supporting structures for the medical devices that are suitable for use in this invention include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. Drugs that are suitable for use in this invention include, but are not limited to, This drug can be used in combination with a drug selected from anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, cytostatic drugs, or combinations of these drugs.

Abstract: A medical device comprising a supporting structure capable of containing or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient may contain one or more therapeutic agents or substances, with the carrier preferably including a coating on the surface thereof, and the coating containing the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature.