Abstract: The principles and embodiments of the present disclosure relate to a composition for improving kidney function in an adult patient with hepatorenal syndrome with rapid reduction in kidney function. The composition includes terlipressin acetate having a formula of C52H74N16O15S2·(C2H4O2)n, where n is 2.8.

Abstract: The principles and embodiments of the present disclosure relate to methods for using terlipressin to treat a patient having impaired renal function associated with liver disease. A method of improving kidney function in an adult patient with hepatorenal syndrome with rapid reduction in kidney function may include determining the patient's acute-on-chronic liver failure (ACLF) grade and baseline serum creatinine level; obtaining a baseline oxygenation saturation (SpO2) of the patient; administering a dose of terlipressin acetate to the patient by intravenous (IV) injection; and monitoring the patient's oxygenation saturation with pulse oximetry.

Abstract: The principles and embodiments of the present disclosure relate to methods for using terlipressin to treat a patient having impaired renal function associated with liver disease. A method of improving kidney function in an adult patient with hepatorenal syndrome with rapid reduction in kidney function may include determining the patient's acute-on-chronic liver failure (ACLF) grade and baseline serum creatinine level; obtaining a baseline oxygenation saturation (SpO2) of the patient; administering a dose of terlipressin acetate to the patient by intravenous (IV) injection; and monitoring the patient's oxygenation saturation with pulse oximetry.

Abstract: The principles and embodiments of the present disclosure relate to methods for using terlipressin to treat a patient having impaired renal function associated with liver disease. A method of improving kidney function in an adult patient with hepatorenal syndrome with rapid reduction in kidney function may include determining the patient’s acute-on-chronic liver failure (ACLF) grade and baseline serum creatinine level; obtaining a baseline oxygenation saturation (SpO2) of the patient; administering a dose of terlipressin acetate to the patient by intravenous (IV) injection; and monitoring the patient’s oxygenation saturation with pulse oximetry.

Abstract: The principles and embodiments of the present disclosure relate to methods for using terlipressin to treat a patient having impaired renal function associated with liver disease. A method of treating an adult patient with type 1 hepatorenal syndrome (HRS-1) may include administering a dose of terlipressin to the patient if the patient has a baseline model end stage liver disease (MELD) score <35, the patient has a serum creatinine (SCr) <5 mg/dl, the patient has an ACLF Grade <3, or a combination thereof and/or monitoring the patient's oxygenation level (SpO2) before and during treatment with the terlipressin.

Abstract: The principles and embodiments of the present disclosure relate to methods of increasing survival of a patient having type 1 hepatorenal syndrome (HRS-1) and low mean arterial pressure (MAP). The methods may include identifying a patient having HRS-1 that has a baseline MAP of less than 65 mmHg, and administering, to the patient, an amount of terlipressin effective to treat the HRS-1 in the patient. In other aspects, the method may include administering an effective dose of terlipressin to a patient in need thereof every 6 hours by intravenous (IV) bolus injection over 2 minutes, where the dose is sufficient to yield an increase in MAP and decrease in heart rate in the patient. The patient may not have overt sepsis, septic shock, or uncontrolled infection.

Abstract: Techniques described herein may provide for end-to-end integration of business systems used in the sale and fulfillment flow for products provided by a business. In one implementation, a method may include receiving a request for a contract relating to products and services offered by a business; and transmitting a message, to one or more workers, indicating that the one or more first workers are to generate the contract. The method may further include receiving the generated contract from the one or more workers; transmitting, in response to reception of a signed version of the contract, a message initiating order fulfillment for the products and services to which the contract relates; determining, as part of the order fulfillment, a plurality of work orders corresponding to the products and services to which the contract relates, and issuing the plurality of work orders to a plurality of provisioning departments of the business.