Abstract: A system for and method of integrated reservoir and seal prediction is useful for evaluation of effective mean stresses affecting geologic systems through their history, and subsequently to predict reservoir and seal quality, flow and seal properties and other behaviors. Porosity and permeability as well as seal properties are modeled based on the effective mean stress. Integrated earth models are built using seismic interpretations, wells and other available data. Geo-mechanical earth models are built and stresses are computed. Basin models are built using inputs from seismic interpretation tools, wells, geochemistry, and earth and mechanical earth models. Reservoir quality and seal quality prediction is performed and the building earth models, computing stresses, building basin models and quality prediction are iterated to converge to a solution that honors well, seismic, core, geochemical and any other available calibration data.