Abstract: This invention manages the variation of neuromodulation sequences inherent in effective treatment for poly-substance abuse and dependence through downloadable neuromodulation protocols for common poly-substance combinations. The substance abuse profiles and the poly-substance neuromodulation protocols are placed on an Internet connected server, allowing effective management of complex treatments via network-attached client software to addiction clinics in most of the geographic areas in the world. Such downloadable protocols may be selected based on the addict's presenting drugs, drug history (from the addict and from appropriate medical personnel), health deficits (e.g. compromised liver) and other factors. Modifications to the downloaded protocol may become desirable as acute withdrawal symptoms emerge or other new information regarding the patient's condition becomes available.