Abstract: The present invention provides a composition comprising the compound having the structure: or a salt of the compound; 4-amino-2-[19F]-fluorobenzoic acid or a salt of 4-amino-2-[19F]-fluorobenzoic acid; and at least one acceptable carrier.

Abstract: Various embodiments of the present invention disclose techniques for orchestrating a complex data processing scheme for an investigative process using a machine-learning based orchestration model that is trained to optimize the use of computing resources based at least in part on a feedback loop. An input data object associated with an investigative process can be selected for investigation; a predictive data analysis sub-routine for processing the input data object can be intelligently selected from a plurality of predictive data analysis sub-routines by the machine-learning based orchestration model; and a processing orchestration action can be initiated based at least in part on an investigative score output by the predictive data analysis sub-routine. The processing orchestration action can include closing the input data object, continuing to process the input data object with additional predictive data analysis sub-routines, or passing the input data object to a predictive entity for further processing.

Abstract: Various embodiments of the present invention disclose techniques for optimizing a plurality of machine-learning based models for an end-to-end investigative process. The techniques include generating a profile for an input data object associated with an investigative process. A first machine-learning based model is used to select a predictive data analysis sub-routine for processing the profile. A second machine-learning based model is used to determine a predictive entity for performing an investigative process for the profile. An investigative outcome is received from the predictive entity. A historical optimization data object is augmented with the investigative outcome, the profile, the predictive data analysis sub-routine, or the predictive entity and the first machine-learning based model and the second machine-learning based model are trained using the historical optimization object.

Abstract: The present invention provides a composition comprising the compound having the structure: or a salt of the compound; 4-amino-2-[19F]-fluorobenzoic acid or a salt of 4-amino-2-[19F]-fluorobenzoic acid; and at least one acceptable carrier.

Abstract: Strategies, systems, compositions, and methods for efficient production of knock-in cellular clones without reporter genes. An essential gene is targeted using a knock-in cassette that comprises an exogenous coding sequence for a gene product of interest (or “cargo sequence”) in frame with and downstream (3?) of an exogenous coding sequence or partial coding sequence of the essential gene. Undesired targeting events create a non-functional version of the essential gene, in essence a knock-out, which is “rescued” by correct integration of the knock-in cassette, which restores the essential gene coding region so that a functional gene product is produced and positions the cargo sequence in frame with and downstream of the essential gene coding sequence.

Abstract: The present invention provides a composition comprising the compound having the structure: or a salt of the compound; 4-amino-2-[19F]-fluorobenzoic acid or a salt of 4-amino-2-[19F]-fluorobenzoic acid; and at least one acceptable carrier.

Abstract: The present invention provides novel 2-pyridone compounds and 4-pyridone compounds and methods of treating a subject infected with a pathogen of Staphylococcus aureus, Mycobacterium tuberculosis, Francisella tularensis, Burkholderia pseudomallei, Yersinia pestis, Escherichia coli and Proteus mirabilisone.

Abstract: The present invention provides novel 2-pyridone compounds and 4-pyridone compounds and methods of treating a subject infected with a pathogen of Staphylococcus aureus, Mycobacterium tuberculosis, Francisella tularensis, Burkholderia pseudomallei, Yersinia pestis, Escherichia coli and Proteus mirabilisone.

Abstract: This invention provides a compound having the structure wherein R1 is H, wherein n and q are independently an integer from 0 to 8; A is absent or present and when present is wherein m is an integer from 0 to 8; R3 is an amino, alkyl, aryl, heteroaryl, diol, piperazine, morpholine, piperidine, triazole, azide or biphenyl, each with or without substitution, branched or unbranched, or and R4 is alkyl, aryl, or heteroaryl, each with or without substitution, branched or unbranched, R2 is H, CH3, or alkyl, aryl, heteroaryl, pyrrole, diazole, or triazole, each with or without substitution, branched or unbranched, or wherein n and q are independently an integer from 0 to 8; A is absent or present and when present is and R6 is azide, methoxy, trifluoromethyl, biphenyl, substituted phenyl, substituted triazole, or alkyl, aryl or heteroaryl, with or without substitution, branched or unbranched, when R1 is H then R2 is other than H or CH3, and

Abstract: This invention provides a compound having the structure wherein R1 is H, wherein n and q are independently an integer from 0 to 8; A is absent or present and when present is wherein m is an integer from 0 to 8; R3 is an amino, alkyl, aryl, heteroaryl, diol, piperazine, morpholine, piperidine, triazole, azide or biphenyl, each with or without substitution, branched or unbranched, or and R4 is alkyl, aryl, or heteroaryl, each with or without substitution, branched or unbranched, R2 is H, CH3, or alkyl, aryl, heteroaryl, pyrrole, diazole, or triazole, each with or without substitution, branched or unbranched, or wherein n and q are independently an integer from 0 to 8; A is absent or present and when present is and R6 is azide, methoxy, trifluoromethyl, biphenyl, substituted phenyl, substituted triazole, or alkyl, aryl or heteroaryl, with or without substitution, branched or unbranched, when R1 is H then R2 is other than H or CH3, and

Abstract: A fire stop for use with a light fixture in a suspended ceiling or wall. It prevents flames and smoke from passing through the light fixture and spreading throughout a building by moving above the ceiling or behind the walls. The fire stop has a lightweight enclosure that defines an interior space disposed above the suspended ceiling, or behind the wall. Contained within the interior space are a portion of the light fixture and a layer of intumescent material. The intumescent material forms a material with a relatively low thermal conductivity that substantially fills the interior space, impeding the movement of flames or smoke, when the intumescent material reaches at least a pre-determined activation temperature.

Abstract: A fire stop for use with a light fixture in a suspended ceiling or wall. It prevents flames and smoke from passing through the light fixture and spreading throughout a building by moving above the ceiling or behind the walls. The fire stop has a lightweight enclosure that defines an interior space disposed above the suspended ceiling, or behind the wall. Contained within the interior space are a portion of the light fixture and a layer of intumescent material. The intumescent material forms a material with a relatively low thermal conductivity that substantially fills the interior space, impeding the movement of flames or smoke, when the intumescent material reaches at least a pre-determined activation temperature.

Abstract: The present invention is directed to compounds having the formula: wherein A1, A3, A6, and A8 independently represent CH or N; A2 represents N or C—X1a—R1; A4 represents N or C—X2b—R2; R1 and R2 independently represent H, or a hydrocarbon containing a minimum of one carbon atom and a maximum of twenty six carbon atoms, wherein the hydrocarbon is unsubstituted, or is substituted with one or more of —OH, —NH2, —SH, halo, or —COOH; X1 and X2 independently represent —O—, —S—, —NH—, —C(O)O—, —C(O)—, —C(O)NH—, or —SO2NH—; a and b independently represent 0 or 1, provided that when a and b are both 0, then R1 and R2 are not both H; when a is 1, then R1 is not H; and when b is 1, then R2 is not H; A5 and A9 independently represent CR3 or N; R3 represents H, methyl, ethyl, or halo; A7 represents CR4 or N; R4 represents H, methyl, ethyl, halo, nitro, hydroxy, amino, amido, or a methyl or ethyl group substituted with halo, nitro, hydroxy, amino, or amido; provided that A2 and A4 are not both N; and not more than thr