Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having core structure (I), pharmaceutical compositions containing at least one such modulator, methods of treatment of CFTR mediated diseases, including cystic fibrosis, using such modulators and pharmaceutical compositions, combination pharmaceutical compositions and combination therapies employing those modulators, and processes and intermediates for making such modulators.

Abstract: A traffic marker illumination device for improving the visibility of a traffic marker to provide warnings for constructions sites and roadways. The traffic marker illumination device is designed to removably attach to an interior portion of a traffic marker. The traffic marker illumination device generates a light to illuminate the traffic marker based on the geographic position of the traffic marker and surrounding environmental elements.

Abstract: In a general aspect, calibration is performed in a quantum computing system. In some cases, domains of a quantum computing system are identified, where the domains include respective domain control subsystems and respective subsets of quantum circuit devices in a quantum processor of the quantum computing system. Sets of measurements are obtained from one of the domains and stored in memory. Device characteristics of the quantum circuit devices of the domain are obtained based on the set of measurements, and the device characteristics are stored in a memory of the control system. Quantum logic control parameters for the subset of quantum circuit devices of the domain are obtained based on the set of measurements and stored in memory.

Abstract: A boom for supporting a drilling and bolting tool includes a first portion including a first end and a second end, a longitudinal axis extending between the first end and the second end; a second portion including a proximal end and a distal end, the proximal end supported for translational movement relative to the first portion in a direction parallel to the longitudinal axis, the distal end configured to support the drilling and bolting tool; an actuator for moving the second portion relative to the first portion parallel to the longitudinal axis; and a fluid passage for conveying pressurized fluid between the first end of the first portion and the drilling and bolting tool adjacent the distal end of the second portion, the fluid passage positioned within the first portion and the second portion.

Abstract: Polymers comprising polyetheretheretherketone and polyetherdiphenyletherketone and polymers comprising polyetheretheretherketone and polyetheretherethersulphone are described which have advantageous Tn and/or Tg properties.

Abstract: An inventive method provides for control of a seismic survey spread while conducting a seismic survey, the spread having a vessel, a plurality of spread control elements, a plurality of navigation nodes, and a plurality of sources and receivers. The method includes the step of collecting input data, including navigation data for the navigation nodes, operating states from sensors associated with the spread control elements, environmental data for the survey, and survey design data. The positions of the sources and receivers are estimated using the navigation data, the operating states, and the environmental data. Optimum tracks for the sources and receivers are determined using the position estimates and a portion of the input data that includes at least the survey design data. Drive commands are calculated for at least two of the spread control elements using the determined optimum tracks. The inventive method is complemented by an inventive system.

Abstract: An inventive method provides for control of a seismic survey spread while conducting a seismic survey, the spread having a vessel, a plurality of spread control elements, a plurality of navigation nodes, and a plurality of sources and receivers. The method includes the step of collecting input data, including navigation data for the navigation nodes, operating states from sensors associated with the spread control elements, environmental data for the survey, and survey design data. The positions of the sources and receivers are estimated using the navigation data, the operating states, and the environmental data. Optimum tracks for the sources and receivers are determined using the position estimates and a portion of the input data that includes at least the survey design data. Drive commands are calculated for at least two of the spread control elements using the determined optimum tracks. The inventive method is complemented by an inventive system.

Abstract: Polymers comprising polyetheretheretherketone and polyetherdiphenyletherketone and polymers comprising polyetheretheretherketone and polyetheretherethersulphone are described which have advantageous Tn and/or Tg properties.

Abstract: A method of performing oilfield operations for an oilfield having a subterranean formation with a reservoir therein is provided. The method involves generating a business analysis of the oilfield based on business inputs, generating an operational analysis of the oilfield based on operational inputs, and selectively integrating the business analysis with the operational analysis by using the operational outputs as at least a portion of the business inputs and by using the business outputs as at least a portion of the operational inputs to form an integrated oilfield analysis. The business analysis includes business outputs for characterizing the business impact of projects performed on the oilfield. The operational analysis includes operational outputs for characterizing the operational impact of projects performed on the oilfield. The integrated oilfield analysis includes integrated oilfield outputs for characterizing the business and operational impact of projects performed on the oilfield.

Abstract: An inventive method provides for control of a seismic survey spread while conducting a seismic survey, the spread having a vessel, a plurality of spread control elements, a plurality of navigation nodes, and a plurality of sources and receivers. The method includes the step of collecting input data, including navigation data for the navigation nodes, operating states from sensors associated with the spread control elements, environmental data for the survey, and survey design data. The positions of the sources and receivers are estimated using the navigation data, the operating states, and the environmental data. Optimum tracks for the sources and receivers are determined using the position estimates and a portion of the input data that includes at least the survey design data. Drive commands are calculated for at least two of the spread control elements using the determined optimum tracks. The inventive method is complemented by an inventive system.

Abstract: The present invention provides a method and apparatus for determining the position of a seismic cable being used to perform a marine seismic survey. The apparatus includes at least one seismic sensor and a plurality of sources deployed in a manner that is structurally independent of the seismic sensors and adapted to provide a positioning signal distinguishable from a seismic survey signal to the seismic sensors.

Abstract: An inventive method provides for control of a seismic survey spread while conducting a seismic survey, the spread having a vessel, a plurality of spread control elements, a plurality of navigation nodes, and a plurality of sources and receivers. The method includes the step of collecting input data, including navigation data for the navigation nodes, operating states from sensors associated with the spread control elements, environmental data for the survey, and survey design data. The positions of the sources and receivers are estimated using the navigation data, the operating states, and the environmental data. Optimum tracks for the sources and receivers are determined using the position estimates and a portion of the input data that includes at least the survey design data. Drive commands are calculated for at least two of the spread control elements using the determined optimum tracks. The inventive method is complemented by an inventive system.

Abstract: A method of performing oilfield operations for an oilfield having a subterranean formation with a reservoir therein is provided. The method involves generating a business analysis of the oilfield based on business inputs, generating an operational analysis of the oilfield based on operational inputs, and selectively integrating the business analysis with the operational analysis by using the operational outputs as at least a portion of the business inputs and by using the business outputs as at least a portion of the operational inputs to form an integrated oilfield analysis. The business analysis includes business outputs for characterizing the business impact of projects performed on the oilfield. The operational analysis includes operational outputs for characterizing the operational impact of projects performed on the oilfield. The integrated oilfield analysis includes integrated oilfield outputs for characterizing the business and operational impact of projects performed on the oilfield.

Abstract: Improved transition state analog inhibitors of ricin toxin-A are provided. Methods of using those inhibitors to inhibit ricin toxin-A and to prevent the toxic effects of rich toxin-A in a mammal are also provided.

Abstract: The present invention provides compounds having the formula: wherein A is CH or N; B is chosen from OH, NH2, NHR, H or halogen; D is chosen from OH, NH2, NHR, H, halogen or SCH3; R is an optionally substituted alkyl, aralkyl or aryl group; and X and Y are independently selected from H, OH or halogen except that when one of X and Y is hydroxy or halogen, the other is hydrogen; and Z is OH or, when X is hydroxy, Z is selected from hydrogen, halogen, hydroxy, SQ or OQ, Q is an optionally substituted alkyl, aralkyl or aryl group; or a tautomer thereof; or a pharmaceutically acceptable salt thereof; or an ester thereof; or a prodrug thereof; and compounds having the formula: wherein A, X, Y, Z and R are defined for compounds of formula (I) where first shown above; E is chosen from CO2H or a corresponding salt form, CO2R, CN, CONH2, CONHR or CONR2; and G is chosen from NH2, NHCOR, NHCONHR or NHCSNHR; or a tautomer thereof, or a pharmaceutically acceptable salt thereof, or an ester thereof, or a prodrug the

Abstract: A process of preparing a compound of the formula (I) wherein B is chosen from OH, NH2, NHR, H or halogen; D is chosen from OH, NH2, NHR, H halogen or SCH3; R is an optionally substituted alkyl, aralkyl or aryl group; and Z is selected from OH, hydrogen, halogen, hydroxy, SQ or OQ, Q is an optionally substituted alkyl, aralkyl or aryl group; or a tautomer thereof; or a pharmaceutically acceptable salt thereof; or an ester thereof; or a prodrug thereof, which comprises reacting a compound of the formula (II) with an anion produced by abstraction of the bromine or iodine atom from a compound of formula (XIX),

Abstract: The present invention provides a compound of formula (I), wherein: A is selected from N, CH and CR, where R is selected from halogen, optionally substituted alkyl, aralkyl and aryl, OH, NH2, NHR1, NR1R2 and SR3, where R1, R2 and R3 are each optionally substituted alkyl, aralkyl or aryl groups; B is selected from OH, NH2, NHR4, H and halogen, where R4 is an optionally substituted alkyl, aralkyl or aryl group; D is selected from OH, NH2, NHR5, H, halogen and SCH3, where R5 is an optionally substituted alkyl, aralkyl or aryl group; X and Y are independently selected from H, OH and halogen, with the proviso that when one of X and Y is hydroxy or halogen, the other is hydrogen; Z is OH, or, when X is hydroxy, Z is selected from hydrogen, halogen, hydroxy, SQ and OQ, where Q is an optionally substituted alkyl, aralkyl or aryl group; and W is OH or H, with the proviso that when W is OH, then A is CR where R is as defined above; or a tautomer thereof; or a pharmaceutically acceptable salt thereof; or an ester thereof

Abstract: The present invention relates to a new process for the preparation of compounds of general formula (I) which are inhibitors of purine nucleoside phosphorylases (PNP), purine phosphoribosyltransferases (PPRT), 5?-methylthioadenosine phosphorylases (MTAP), 5?-methylthioadenosine nucleosidases (MTAN) and/or nucleoside hydrolases (NH).The present invention relates to a new process for the preparation of compounds of general formula (I) which are inhibitors of purine nucleoside phosphorylases (PNP), purine phosphoribosyltransferases (PPRT), 5?-methylthioadenosine phosphorylases (MTAP), 5?-methylthioadenosine nucleosidases (MTAN) and/or nucleoside hydrolases (NH).

Abstract: The present invention relates to compounds of the general formula (I) which are inhibitors of purine muclioside phosphorylases (PNP), purine phosphoribosyltransferases (PPRT), 5?-methylthioadenosine phosphorylases (MTAP), 5?-methylthioadenosine mucliosidases (MTAN) and/or nucleoside hydrolases (NH). The invention also relates to the use of these compounds in the treatment of diseases and infections including cancer, bacterial infections, protozoal infections, and T-cell mediated disease and to pharmaceutical compositions containing the compounds.

Abstract: A process of preparing a compound of the formula (I) wherein B is chosen from OH, NH2, NHR, H or halogen; D is chosen from OH, NH2, NHR, H halogen or SCH3; R is an optionally substituted alkyl, aralkyl or aryl group; and Z is selected from OH, hydrogen, halogen, hydroxy, SQ or OQ, Q is an optionally substituted alkyl, aralkyl or aryl group; or a tautomer thereof; or a pharmaceutically acceptable salt thereof; or an ester thereof; or a prodrug thereof, which comprises reacting a compound of the formula (II) with an anion produced by abstraction of the bromine or iodine atom from a compound of formula (XIX), to form a compound of formula (XX) The compound of formula (XX) is N- and O-deprotected to obtain the compound of formula (I).