Patents by Inventor Peter V. GRAUMAN

Peter V. GRAUMAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COPY NUMBER VARIANT CALLER
    Publication number: 20220108767
    Abstract: Direct targeted sequencing (DTS) methods and a hidden Markov model (HMV) can be used to call the copy number of a segment of interest within a region of interest. Described herein are methods for calling a copy number variant or a copy number variant abnormality using an HMM, and methods for determining a copy number based on a copy number likelihood model, in a test sequencing library that has be sequenced using DTS methods. Also described herein are methods for determining a copy number of a segment, including accounting for spurious capture probes that may arise from the DTS methods.
    Type: Application
    Filed: December 17, 2021
    Publication date: April 7, 2022
    Applicant: Myriad Women's Health, Inc.
    Inventors: Kevin R. HAAS, Xin WANG, Peter V. GRAUMAN
  • Copy number variant caller
    Patent number: 11232850
    Abstract: Direct targeted sequencing (DTS) methods and a hidden Markov model (HMM) can be used to call the copy number of a segment of interest within a region of interest. Described herein are methods for calling a copy number variant or a copy number variant abnormality using an HMM, and methods for determining a copy number based on a copy number likelihood model, in a test sequencing library that has be sequenced using DTS methods. Also described herein are methods for determining a copy number of a segment, including accounting for spurious capture probes that may arise from the DTS methods.
    Type: Grant
    Filed: March 23, 2018
    Date of Patent: January 25, 2022
    Assignee: Myriad Genetics, Inc.
    Inventors: Kevin R. Haas, Xin Wang, Peter V. Grauman
  • COPY NUMBER VARIANT CALLER
    Publication number: 20180285522
    Abstract: Direct targeted sequencing (DTS) methods and a hidden Markov model (HMM) can be used to call the copy number of a segment of interest within a region of interest. Described herein are methods for calling a copy number variant or a copy number variant abnormality using an HMM, and methods for determining a copy number based on a copy number likelihood model, in a test sequencing library that has be sequenced using DTS methods. Also described herein are methods for determining a copy number of a segment, including accounting for spurious capture probes that may arise from the DTS methods.
    Type: Application
    Filed: March 23, 2018
    Publication date: October 4, 2018
    Inventors: Kevin R. HAAS, Xin WANG, Peter V. GRAUMAN