Abstract: A method comprising accessing a first data structure that is associated with a first product prepared by a student and that includes first process data associated with a process performed by the student in generating the first product, analyzing the first data structure to generate a first characterization score based on the first product and the first process data, accessing a second data structure that is associated with a second product prepared by the student and that includes second process data associated with a process performed by the student in generating the second product, analyzing the second data structure to generate a second characterization score based on the second product and the second process data, and calculating a skill level change metric based on the first characterization score and the second characterization score indicating a change in ability level of the student over a course of the scenario-based assessment.

Abstract: The invention provides novel immunogenic peptides derived from the X protein and polymerase protein of hepatitis B virus (HBV). The peptides contain epitopes that are well-conserved across multiple HBV variants and are derived from regions of proteins that are essential for viral replication. Moreover, the novel HBV antigens bind multiple HLA types and epitopes that elicit IFN? responses in PBMCs from HBV resolvers have been identified.

Abstract: The invention provides long immunogenic peptides for treating diseases related to severe acute respiratory syndrome coronaviruses, such as SARS-CoV-2 or SARS-CoV-1. The invention also provides immunogenic compositions and vaccines comprises long immunogenic peptides of the invention and method of therapeutic treatment or prevention of SARS-CoV-related diseases comprising administration of immunogenic peptides according to the invention.