Abstract: A computer-implemented method may be provided to aid in radiation treatment planning, the method comprising: receiving treatment plan parameters including a reference dose value for a target region of a patient and a defined dose value for a surrounding region; determining whether the defined dose value for the surrounding region exceeds a threshold; and responsive to determining that the defined dose value for the surrounding region does not exceed the threshold, modifying the defined dose value for the surrounding region, and applying an optimization procedure to a treatment plan for radiation treatment of the patient with the modified dose value for the surrounding region.

Abstract: A computer-implemented method may be provided to aid in radiation treatment planning, the method comprising: receiving a reference objective, the reference objective representing a goal to be achieved by a radiotherapy system; selecting a cost function associated with the reference objective from a plurality of cost functions, the selected cost function being associated with an assigned initial weight value, the assigned initial weight value corresponding to sensitivity of an example dose distribution relative to changes in the selected cost function; applying an optimization procedure to a radiation treatment plan for radiation treatment in a patient according to the received reference objective, wherein the optimization procedure uses the assigned initial weight value of the selected cost function and seeks to minimize the selected cost function.

Abstract: A computer-implemented method for radiation treatment planning, the method comprising: receiving a reference dose value, wherein the reference dose value is a defined maximum radiation dose within a first region for radiation treatment in a patient; applying an optimization procedure to a treatment plan for radiation treatment of the patient, wherein the optimization procedure seeks to minimize a cost function which is representative of a dose excess value above the reference dose value; and responsive to determining that the dose excess value is below a threshold value: decreasing the reference dose value; and reapplying the optimization procedure to the treatment plan, wherein the optimization procedure seeks to minimize the cost function based on the decreased reference dose value.

Abstract: A method for radiation treatment planning for delivering radiation therapy by a radiotherapy system, the method comprising: receiving a reference objective, the reference objective representing a goal to be achieved by the radiotherapy system; performing an optimisation procedure, according to the received reference objective, to determine a set of parameters, the set of parameters relating to characteristics of radiation to be delivered by the radiotherapy system, wherein the optimisation procedure comprises: optimising the set of parameters to obtain an achieved value, and responsive to the achieved value not meeting the reference objective, obtaining a relaxed objective using the achieved value and a relaxation value, and determining a configuration of the radiotherapy system using the optimised set of parameters and the relaxed objective.

Abstract: A method of radiation treatment planning for a radiotherapy system, the method comprising: receiving a first reference objective and a second reference objective, each reference objective representing a goal to be achieved by the radiotherapy system, and the first reference objective comprising a reference dose to be delivered to a reference volume of an anatomical structure, optimising a set of parameters, according to the received first reference objective and the received second reference objective, the set of parameters relating to characteristics of radiation to be delivered by the radiotherapy system, wherein optimising the set of parameters comprises: optimising the set of parameters based on the first reference objective to obtain a dose-volume metric for the anatomical structure, and further optimising the set of parameters based on the second reference objective using the dose-volume metric as constraint, and generating a radiation treatment plan using the further optimised set of parameters.