Abstract: A concierge system sends batches of orders to pickers that they can review and accept in a batch list on a client device. Each batch in the batch list is presented with a hide option that enables the picker to hide a batch that they do not intend to accept. In response to receiving a hide signal, the system extracts features associated with the batch and stores those features with a negative indication of the picker towards the batch. The hide signal provides the system with a higher quality signal indicating the picker's negative intent regarding an order, as compared to simply ignoring the order in favor of fulfilling another order. This higher quality signal is then used to train models to better predict events related to the pickers' acceptance of orders, such as for ranking orders for pickers or for predicting fulfillment times.

Abstract: Described herein are methods and compositions for use in improving a vascular barrier of endothelial cells. The methods may include the use of barrier agonist compounds and improved techniques for culturing endothelial cells. The improved methods and compositions for culturing endothelial cells may include at least one or more of the following: an adenylyl cyclase activator; an activator of Sphingosine-1-phosphate (S1P) receptor internalization; a direct or indirect inducer of tight junction protein expression, and a direct or indirect inducer of adherens junction protein expression.