Patents by Inventor Peter W. Carr
Peter W. Carr has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11692980Abstract: A multi-dimensional liquid analysis system includes a flow splitter for separating mobile phase outflow from a first dimension liquid analysis system into first and second liquid split outlet flows. Volumetric flow rate control of the split outlet flows is provided by a flow control pump which withdraws one of the split outlet flows from the flow splitter at a controlled withdrawal flow rate to define the other split outlet flow rate as the difference between the outflow rate from the first dimension system and the withdrawal flow rate. In this manner, accurate and consistent flow division can be accomplished, which is particularly useful for multi-dimensional liquid analysis.Type: GrantFiled: September 19, 2019Date of Patent: July 4, 2023Assignee: Regents of the University of MinnesotaInventors: Carl W. Sims, Peter W. Carr, Marcelo Filgueira, Klaus Witt
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Publication number: 20200025726Abstract: A multi-dimensional liquid analysis system includes a flow splitter for separating mobile phase outflow from a first dimension liquid analysis system into first and second liquid split outlet flows. Volumetric flow rate control of the split outlet flows is provided by a flow control pump which withdraws one of the split outlet flows from the flow splitter at a controlled withdrawal flow rate to define the other split outlet flow rate as the difference between the outflow rate from the first dimension system and the withdrawal flow rate. In this manner, accurate and consistent flow division can be accomplished, which is particularly useful for multi-dimensional liquid analysis.Type: ApplicationFiled: September 19, 2019Publication date: January 23, 2020Inventors: Carl W. Sims, Peter W. Carr, Marcelo Filgueira, Klaus Witt
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Patent number: 10429361Abstract: A multi-dimensional liquid analysis system includes a flow splitter for separating mobile phase outflow from a first dimension liquid analysis system into first and second liquid split outlet flows. Volumetric flow rate control of the split outlet flows is provided by a flow control pump which withdraws one of the split outlet flows from the flow splitter at a controlled withdrawal flow rate to define the other split outlet flow rate as the difference between the outflow rate from the first dimension system and the withdrawal flow rate. In this manner, accurate and consistent flow division can be accomplished, which is particularly useful for multi-dimensional liquid analysis.Type: GrantFiled: January 15, 2016Date of Patent: October 1, 2019Assignee: Regents of the University of MinnesotaInventors: Carl W. Sims, Peter W. Carr, Marcelo Roberto Filgueira, Klaus Witt
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Publication number: 20160131619Abstract: A multi-dimensional liquid analysis system includes a flow splitter for separating mobile phase outflow from a first dimension liquid analysis system into fist and second liquid split outlet flows. Volumetric flow rate control of the split outlet flows is provided by a flow control pump which withdraws one of the split outlet flows from the flow splitter at a controlled withdrawal flow rate to define the other split outlet flow rate as the difference between the outflow rate from the first dimension system and the withdrawal flow rate. In this manner, accurate and consistent flow division can be accomplished, which is particularly useful for multi-dimensional liquid analysis.Type: ApplicationFiled: January 15, 2016Publication date: May 12, 2016Inventors: Carl W. Sims, Peter W. Carr, Marcelo Roberto Filgueira, Klaus Witt
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Patent number: 9239319Abstract: A multi-dimensional liquid analysis system includes a flow splitter for separating mobile phase outflow from a first dimension liquid analysis system into first and second liquid split outlet flows. Volumetric flow rate control of the split outlet flows is provided by a flow control pump which withdraws one of the split outlet flows from the flow splitter at a controlled withdrawal flow rate to define the other split outlet flow rate as the difference between the outflow rate from the first dimension system and the withdrawal flow rate. In this manner, accurate and consistent flow division can be accomplished, which is particularly useful for multi-dimensional liquid analysis.Type: GrantFiled: March 16, 2012Date of Patent: January 19, 2016Assignee: Regents of the University of MinnesotaInventors: Carl W. Sims, Peter W. Carr, Marcelo Roberto Filgueira, Klaus Witt
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Patent number: 9073038Abstract: Methods using homogeneous precipitation of a metal on a surface of a particle to prepare silica particles having the metal adsorbed thereon are disclosed herein. In certain embodiments, the silica particles having the metal adsorbed thereon can be used to prepare carbon coated silica particles. The carbon coated silica particles can be useful in a wide variety of applications including, for example, for use as sorbents in chromatography.Type: GrantFiled: May 26, 2011Date of Patent: July 7, 2015Assignee: Regents of the University of MinnesotaInventors: Peter W. Carr, Alon V. McCormick, Changyub Paek
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Publication number: 20130157846Abstract: Methods using homogeneous precipitation of a metal on a surface of a particle to prepare silica particles having the metal adsorbed thereon are disclosed herein. In certain embodiments, the silica particles having the metal adsorbed thereon can be used to prepare carbon coated silica particles. The carbon coated silica particles can be useful in a wide variety of applications including, for example, for use as sorbents in chromatography.Type: ApplicationFiled: May 26, 2011Publication date: June 20, 2013Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Peter W. Carr, Alon V. McCormick, Changyub Paek
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Patent number: 6991852Abstract: A silica-based material that includes a silica-based substrate and a polymerized organic material disposed thereon. The polymerized organic material is made from reactive organic moieties bonded to the silica-based substrate.Type: GrantFiled: March 11, 2003Date of Patent: January 31, 2006Assignee: Regents of the University of MinnesotaInventors: Peter W. Carr, Marc A. Hillmyer, Huqun Liu, Hao Luo, Lianjia Ma, Brian C. Trammell
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Patent number: 6846410Abstract: The present invention describes the use of porous metal oxides for the preparative purification of antibodies and biomolecules within a range of particle physical characteristics. Typically, particles from 15 to 100 microns in average diameter with pores sizes ranging from 400 to 600 angstroms and surface areas from 10 to 50 square meters per gram, and pore volumes from 0.1 to 0.4 mL/gram can be used for purification processes. The metal oxide particles that fall within this range of physical properties show enhanced utility and greater chromatographic capacity for antibodies than materials oxide particles falling outside of this range. Metal oxides such as zirconia, titania and alumina can all be modified with a multi-Lewis base moiety such as an organophosphate ethylenediamine-N,N-tetra(methylenephosphonic) acid (EDTPA), to produce a bio-compatible purification media for, biomolecules.Type: GrantFiled: May 2, 2003Date of Patent: January 25, 2005Assignee: ZirChrom Separations, Inc.Inventors: Clayton V. McNeff, Peter W. Carr, Steven J. Rupp, Dwight R. Stoll, Danielle R. Hawker, Lorinda D. Zigan, Kerry G. Johnson
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Publication number: 20040071968Abstract: The present invention relates to compositions comprising surface modified carbon-clad metal oxide membranes and monoliths. In particular the invention relates to membranes and/or monoliths comprising carbon-clad metal oxide, functionalized with an organic functional group. This organic functional group, either a small molecule or a polymer, can be chosen for specific end-uses, such as selective protein binding, ion exchange, hydrophobic interaction, chiral selection to enhance separations technology.Type: ApplicationFiled: February 25, 2003Publication date: April 15, 2004Inventors: Agathagelos Kyrlidis, Feng Gu, Clayton V. McNeff, Peter W. Carr
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Publication number: 20040007530Abstract: The present invention describes the use of porous metal oxides for the preparative purification of antibodies and biomolecules within a range of particle physical characteristics. Typically, particles from 15 to 100 microns in average diameter with pores sizes ranging from 400 to 600 angstroms and surface areas from 10 to 50 square meters per gram, and pore volumes from 0.1 to 0.4 mL/gram can be used for purification processes. The metal oxide particles that fall within this range of physical properties show enhanced utility and greater chromatographic capacity for antibodies than materials oxide particles falling outside of this range. Metal oxides such as zirconia, titania and alumina can all be modified with a multi-Lewis base moiety such as an organophosphate ethylenediamine-N,N-tetra(methylenephosphonic) acid (EDTPA), to produce a bio-compatible purification media for, biomolecules.Type: ApplicationFiled: May 2, 2003Publication date: January 15, 2004Inventors: Clayton V. McNeff, Peter W. Carr, Steven J. Rupp, Dwight R. Stoll, Danielle R. Hawker, Lorinda D. Zigan, Kerry G. Johnson
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Publication number: 20030219597Abstract: A silica-based material that includes a silica-based substrate and a polymerized organic material disposed thereon. The polymerized organic material is made from reactive organic moieties bonded to the silica-based substrate.Type: ApplicationFiled: March 11, 2003Publication date: November 27, 2003Applicant: Regents of the University of MinnesotaInventors: Peter W. Carr, Marc A. Hillmyer, Huqun Liu, Hao Luo, Lianjia Ma, Brian C. Trammell
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Publication number: 20020160196Abstract: Metal oxide microspheres, particularly zirconia microspheres, produced by a method of hydrolysis of metal alkoxides in alcohol solutions in the presence of an organic acid or salt thereof with washing step or addition of a surfactant.Type: ApplicationFiled: October 29, 2001Publication date: October 31, 2002Applicant: Regents of the University of MinnesotaInventors: Peter W. Carr, Alon V. McCormick, Bingwen Yan, Clayton V. McNeff, Fang Chen
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Publication number: 20020117446Abstract: Separation devices and systems are described which have a stationary phase and a mobile phase, wherein the stationary phase contains carbon-clad zirconium dioxide particles having attached at least one organic group. The stationary phase which is used in the present invention has the ability to dial in the selectivity by attaching the proper organic groups onto the carbon-clad zirconium dioxide particles in order to achieve the desired separation. Various separation processes are described such as chromatography, electrophoresis, magnetic separations, membrane separations, and the like. The processes to accomplish these types of separations are also described.Type: ApplicationFiled: August 31, 2001Publication date: August 29, 2002Inventors: Agathagelos Kyrlidis, Steven R. Reznek, James A. Belmont, Peter W. Carr, Clayton V. McNeff
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Patent number: 6036861Abstract: Porous Zirconia particles of specific gravity of 2.5-3.5 g/cm.sup.3 and mean particle sizes of 30-400 .mu.m can be synthesized using oil emulsion methods from colloids and used for protein adsorption in stable expanded beds. Expanded beds of less than 1.0 settled bed height to diameter (approximately 10 ml bed volume) are stable at linear fluid velocities of at least about 100 cm/hour.Type: GrantFiled: August 6, 1998Date of Patent: March 14, 2000Assignee: Regents of the University of MinnesotaInventors: Michael C. Flickinger, Michael J. Robichaud, John E. Morris, Colleen M. Griffith, Michael J. Annen, Peter W. Carr, Christopher Dunlap
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Patent number: 5837826Abstract: Porous zirconia particles of specific gravity of 2.5-3.5 g/cm.sup.3 and mean particle sizes of 30-400 .mu.m can be synthesized using oil emulsion methods from colloids and used for protein adsorption in stable expanded beds. Expanded beds of less than 1.0 settled bed height to diameter (approximately 10 ml bed volume) are stable at linear fluid velocities of at least about 100 cm/hour.Type: GrantFiled: February 27, 1995Date of Patent: November 17, 1998Assignee: Regents of The University of MinnesotaInventors: Michael C. Flickinger, Michael J. Robichaud, John E. Morris, Colleen M. Griffith, Michael J. Annen, Peter W. Carr, Christopher Dunlap
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Patent number: 5540834Abstract: The present invention provides improved methods for the preparation of porous inorganic particles. The methods involve combining an aqueous sol containing a colloidal dispersion of inorganic particles with a polymerizable organic material, polymerizing this material, and thereby forming aggregates of colloidal particles and polymer.Type: GrantFiled: August 23, 1994Date of Patent: July 30, 1996Assignee: Regents of the University of MinnesotaInventors: Peter W. Carr, Alon V. McCormick, Michael J. Annen, Lifang Sun, Jason R. Brown
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Patent number: 5346619Abstract: Carbon-clad zirconium oxide particles are disclosed which are useful in sorbent applications, particularly as packing materials for High Performance Liquid Chromatography (HPLC). A method for the preparation of chromatographic support material is also disclosed which utilizes low pressure.Type: GrantFiled: July 14, 1993Date of Patent: September 13, 1994Assignee: Regents of the University of MinnesotaInventors: Eric F. Funkenbusch, Peter W. Carr, Douglas A. Hanggi, Thomas P. Weber
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Patent number: 5271833Abstract: Polymer-coated carbon-clad inorganic oxide particles are disclosed which are useful in sorbent applications, particularly as packing materials for High Performance Liquid Chromatography (HPLC). A method for the preparation of a chromatographic support material is also disclosed which comprises coating carbon-clad inorganic oxide particles with a monomer or oligomer and cross-linking the monomer or oligomer.Type: GrantFiled: October 20, 1992Date of Patent: December 21, 1993Assignee: Regents of the University of MinnesotaInventors: Eric F. Funkenbusch, Peter W. Carr, Douglas A. Hanggi, Thomas P. Weber
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Patent number: RE34910Abstract: Carbon-clad zirconium oxide particles are disclosed which are useful in sorbent applications, particularly as packing materials for High Performance Liquid Chromatography (HPLC). A method for the preparation of chromatographic support material is also disclosed which utilizes low pressure.Type: GrantFiled: April 1, 1993Date of Patent: April 18, 1995Assignee: Regents of the University of MinnesotaInventors: Eric F. Funkenbusch, Peter W. Carr, Douglas A. Hanggi, Thomas P. Weber