Abstract: (2S)-2-[1-(2-Chloro-6-cyano-phenyl)pyrazolo[4,5-e]pyrimidin-4-yl]oxy-3-[(1R)-2-hydroxy-1-methyl-ethoxy]-N-(5-methylpyrazin-2-yl)propanamide or a pharmaceutically acceptable salt thereof is useful in the treatment or prevention of a disease or medical condition mediated through glucokinase (GLK or GK), leading to a decreased glucose threshold for insulin secretion.

Abstract: A compound of Formula (I): is useful in the treatment or prevention of a disease or medical condition mediated through glucokinase (GLK or GK), leading to a decreased glucose threshold for insulin secretion.

Abstract: A method of reducing nitrogen oxides (NOx) in a flowing combustion exhaust gas to N2, which method comprising oxidising nitrogen monoxide to nitrogen dioxide on a transition metal/elite catalyst at catalyst bed temperatures below 50° C. and reducing NOx with the catalyst using an hydrocarbon (HC) reductant at catalyst bed temperatures below 150° C.

Abstract: The present invention relates generally to methods and systems for searching and retrieving records from a database and in particular to capturing a user's preferences to facilitate retrieval of records from the database in accordance with those preferences. The invention is suitable for use in applications in which the records retrieved from the database correspond to books, films, music or the like and it will be convenient to describe the invention in relation to that exemplary, but non-limiting, application.

Abstract: An apparatus comprising a compression ignition engine and an exhaust system therefor comprising at least one exhaust system component for treating exhaust gas and means for generating an exotherm for heating the at least one exhaust system component, which exotherm generating means consisting essentially of a catalyst and means for injecting hydrocarbon into exhaust gas for combustion on the catalyst, which catalyst consisting essentially of both a palladium (Pd) component and a platinum (Pt) component, and an optional support material, disposed on a substrate monolith.

Abstract: A constrained prosthetic knee having a modular hinge post and a rotating bearing. A cannulated hinge post is rotatably connected to the femoral component of the knee prosthesis so that a hinge post extension may be anteriorly positioned through the hinge post and into the tibial component of the knee prosthesis, after positioning of the femoral component in the femur and the tibial component in the tibia. The hinge post is preassembled to the femoral component so that such assembly is not required during the implantation procedure. A meniscal component forming the rotating bearing of the knee prosthesis is packaged together with the hinge post extension so that the appropriate hinge post extension is readily available. The meniscal component includes a mechanism for preventing lift off of the meniscal component from the tibial component, while allowing rotation of the meniscal component relative to the tibial component.

Abstract: A system for allowing a user to remotely access a game includes: a game console; a remote console client configured to receive a game control signal; and a remote console server. The remote console server includes an audio and video encoder configured to receive an audio output and a video output from the game console and to convert the audio output and the video output to a network packet. The remote console server also includes: a game controller emulation unit and a network interface configured to send and receive the network packet. The game controller emulation unit is configured to receive a game controller signal from the game console and to send the game controller signal to the remote console client and to receive a game controller input from the remote console client and send the game controller input to the game console.

Abstract: A steam turbine (20), in particular for high pressure and/or intermediate pressure applications, has a rotor (11), which can rotate about an axis (23), an inner casing (14), which concentrically surrounds the rotor (11) at a distance, so as to form an annular passage (12) extending in the axial direction, and an outer casing (13), which concentrically surrounds the inner casing (14) at a distance so as to form an annular intermediate space (16) extending in the axial direction, blading including rotor blades (21) and guide vanes (22) being provided in the annular passage (12), and the annular passage (12), on the outlet side, being in communication with the intermediate space (16) in order for the steam to be passed on, and the inner casing (14) also being externally surrounded by a plurality of shrink rings (15), which are arranged one behind the other in the axial direction and project into the intermediate space (16).

Abstract: A method of selectively catalysing the reduction of NOx in an exhaust gas flowing in an exhaust system of an internal combustion engine comprising a filter (40) for particulate matter comprising a catalyst capable of selectively catalysing the reduction of NOx with a reducing agent, which method comprising introducing a reducing agent, or a precursor thereof, into the exhaust gas and contacting the resulting gas with the filter (40).

Abstract: An artificial knee joint that includes a femoral component with a specially shaped bearing surface and a tibial component, whose surface interacts with the femoral surfaces. The interaction provides for the required motion and stability characteristics. The interaction between the femoral and tibial surfaces is such that as the knee is flexed to maximum, the femoral component moves posteriorly on the tibial surface, by an amount similar to that in the anatomic knee. This is accomplished primarily by the depth and width of the femoral trochlea diminishing as the femoral component is flexed from zero to maximum, together with a ramp on the center of the tibial surface. The opposite motion, roll forward of the femur from a fully flexed to a more extended position, is accomplished by varying the outward radii of the lateral and medial femoral bearing surfaces, together with a ramp on the postero-lateral and postero-medial regions of the tibial surfaces.

Abstract: An artificial knee joint that includes a femoral component with a specially shaped bearing surface and a tibial component, whose surface interacts with the femoral surfaces. The interaction provides for the motion and stability characteristics of the anatomic knee. The interaction between the femoral and tibial surfaces is such that as the knee is flexed to maximum, the femoral component moves posteriorly on the tibial surface, more so on the lateral side than on the medial side. This is accomplished by the interaction of a projecting tibial post inside a cupola in the center of the femoral component, and by the saggital radius on the medial side being smaller than that on the lateral side. The prevention of anterior sliding of the femur on the tibia in early flexion is accomplished by the interaction between a distal-anterior recess on the medial side of the femur and an apposing raised pad on the tibial surface.

Abstract: A method and apparatus for providing remote access redirect in a host channel adapter of a system area network are provided. The apparatus and method provide a mechanism by which a host channel adapter, in response to receiving a marker message, places selected channel(s) of the host channel adapter in a remote access redirect (RAR) mode of operation. During the RAR mode of operation, memory access messages received by the host channel adapter that are destined for portions of an application memory space marked as being protected are converted to RAR receive messages and redirected to a queue pair associated with an operating system rather than the queue pair for the application. The operating system is responsible for serializing access to application memory pages outside of the host channel adapter. The mechanisms of the present invention may be used to perform a checkpoint data integrity operation.

Abstract: A system for locking and unlocking containers to transport modes and other containers comprises a plate and spring housed in an upper corner fitting of a container, a cable connected to the plate, and guides to route the cable from the plate to a rotatable locking leg housed in a lower corner fitting of the container. The twist lock of a lifting spreader engages the upper corner fitting of a container, urging the plate and spring in the upper corner fitting downward. The cable is pulled downward by the depression of the plate, accordingly pulling the locking leg, causing it to rotate to an unlocked position.

Abstract: The present invention provides a method, data processing apparatus and computer program product which displays status information with the mouse symbol, the status information relating to an operation being performed with a mouse cursor. For example, the status information may provides position co-ordinates relating to the cursor symbol.

Abstract: A system and method is provided for controlling a distributed computing environment. The distributed computing environment is controlled by controlling flows, streams, and pipes used by applications within the distributed computing environment. The controls on each of the flows, streams, and pipes include latency, priority, a connection throttle, and a network packet throttle. Parameters for determining the values for each of the controls are based on any one or more of Virtual Local Area Network Identifier (VLAN ID), source address, destination address, source port, destination port, protocol, connection request, and transaction type load tag.

Abstract: The invention is directed to a method which derives from metadata definitions the allowable values for a method argument, where said allowable values are a subset or a restricted set of values from a defined range of values for that type of method argument. The subset of allowable values is then converted into a fragment of source code that can be used to initialise the argument variable with one of the allowable values when the method is invoked. The fragment of source code is inserted into the source code for that method argument using an editor tool. A system for implementing the method may comprise an integrated development environment (IDE) program.

Abstract: Systems and methods are described which allow communications in an application infrastructure to be prioritized based on a wide variety of factors, including the component or application flow with which the communications are associated. A communication may be received and classified into one of a series of application-specific data flows. In one embodiment, a priority value may be calculated and assigned to the communication based on the application-specific data flow assigned to the communication. The communication may then be forwarded to its intended destination based on the assigned priority.

Abstract: A mobile bearing knee prosthesis apparatus includes a tibial plate. The tibial plate includes a medial lobe and a lateral lobe conjoined in a dividing plane. The apparatus further includes a tibio-femoral insert and a stud-like protuberance extending from the tibial plate into the tibio-femoral insert. The stud-like protuberance includes a protuberance sidewall positioned in the tibio-femoral insert. The protuberance sidewall is bisected by the dividing plane and includes a pair of opposing eccentric convex arcuate portions, and the tibio-femoral insert is moveable relative to the tibial plate about an axis medially disposed from the dividing plane. A mobile bearing knee prosthesis apparatus includes a tibial plate and a tibio-femoral insert coupled to the tibial plate. The tibio-femoral insert includes a generally posteriorly positioned chamfered superior surface and defines a generally posteriorly positioned generally U-shaped space bounded at least in part by the chamfered surface.

Abstract: A bone surgery device with a reciprocating cutting head. The device comprises several sets of shaping surfaces sometimes including cutting blades, which are located and oriented so as to shape the distal end of the femur and the proximal end of the tibia for total knee replacements and unicompartmental knee replacements. The device, which may be hand directed or aided by spatial and directional guiding mechanisms or an optical navigation system, may also include both coolant supply for controlling heat during bone cutting and shaping, and a suction method for carrying away fluid and debris. The device is substantially configured to the artificial joint component to be attached thereto.

Abstract: A bone surgery device with a reciprocating cutting head. The device comprises several sets of shaping surfaces sometimes including cutting blades, which are located and oriented so as to shape the distal end of the femur and the proximal end of the tibia for total knee replacements and unicompartmental knee replacements. The device, which may be hand directed or aided by spatial and directional guiding mechanisms or an optical navigation system, may also include both coolant supply for controlling heat during bone, cutting and shaping, and a suction method for carrying away fluid and debris. The device is substantially configured to the artificial joint component to be attached thereto.