Abstract: A compound, or a pharmaceutically acceptable salt or ester thereof, comprises the structure: [(P1-S1j)p-L-(S2q-P2)r]t wherein: P1 and P2, which may be the same or different, are cyclic oligopeptide moieties, at least one of P1 and P2 having the motif B-Arg or B-(Me)Arg within the cyclic moiety, wherein B is a basic amino acid, a derivative thereof, or phenylalanine or a derivative thereof; S1 and S2 are spacer groups, which may be the same or different; L is a linker moiety containing at least two functional groups for attachment of the cyclic oligopeptides or spacer groups; n and q are independently 0 or 1; p and r are independently integers of 1 or more; and t is an integer of 1 or more, provided that, when t, p or r is greater than 1, the cyclic oligopeptide moiety, spacer group and/or the value of j or q may be the same or different between the multiple (P1-S1j) moieties or multiple (S2q-P2) moieties.

Abstract: A pair of endoscopic scissors having an actuating means at the proximal end and a pair of pivotable scissor blades at the distal end. The actuating means is adapted to be squeezed to a predetermined point when the scissor blades are fully closed, at least one of the blades being provided with a stop surface adjacent its proximal end in order to prevent the blade tips from crossing over each other in their fully closed position. The gap between the actuating means at the proximal end of the instrument enable the application of additional force between the pivotable scissor blades without causing the blades to cross-over each other.