Abstract: Systems and methods for analyzing genetic sequence data involve: (a) obtaining, by a computer system, genetic sequencing data pertaining to a subject; (b) splitting the genetic sequencing data into a plurality of segments; (c) processing the genetic sequencing data such that intra-segment reads, read pairs with both mates mapped to the same data set, are saved to a respective plurality of individual binary alignment map (BAM) files corresponding to that respective segment; (d) processing the genetic sequencing data such that inter-segment reads, read pairs with both mates mapped to different segments, are saved into at least a second BAM file; and (e) processing at least the first plurality of BAM files along parallel processing paths. The plurality of segments may correspond to any given number of genomic subregions and may be selected based upon the number of processing cores used in the parallel processing.

Abstract: A pneumatic vibration isolating suspension is disclosed for supporting a payload on a moving carrier while suppressing the transmission of vibrations in the 1 to 50 Hz band between the carrier and the payload. The disclosed invention can be deployed in the air in a towed carrier or sonde, and operated from aircraft power, making it a suitable platform for airborne geophysical instrumentation. It also has particular application to airborne electromagnetic surveying operating in the same frequency band because the sensor vibrations that result in noise created by the modulation of the sensor coupling with the earth's magnetic field are suppressed. Furthermore, the invention can be constructed from resistive composite materials and non-magnetic metals, so it can be operated without producing significant modification to the ambient electromagnetic field being measured.

Abstract: An article handling apparatus for gripping and moving an article such as a large tire or other vehicular component of a mining, earthmoving or like vehicle. The article handling apparatus includes a base frame for movement of the apparatus over a substrate surface, and a handling frame for gripping the article, such as a tire. The apparatus has a pair of moveable arm members on the base frame, and a pair of moveable arm members on the handling frame. The apparatus can be compactly stored by contraction of the arms, can be manipulated through tight spaces, and is extremely stable while handling large and heavy articles.

Abstract: One embodiment relates to a method of inspecting a site location on a target substrate. Contours are obtained, the contours having been generated from a reference image using a design clip. A target image of the site location is acquired. The contours are aligned to the target image, and contrast values are computed for pixels on the contours. A threshold is applied to the contrast values to determine contour-based defect blobs. Another embodiment relates to a method of generating contours for use in inspecting a site location for defects. Other embodiments, aspects and features are also disclosed.

Abstract: An article handling apparatus for gripping and moving an article such as a large tire or other vehicular component of a mining, earthmoving or like vehicle. The article handling apparatus includes a base frame for movement of the apparatus over a substrate surface, and a handling frame for gripping the article, such as a tire. The apparatus has a pair of moveable arm members on the base frame, and a pair of moveable arm members on the handling frame. The apparatus can be compactly stored by contraction of the arms, can be manipulated through tight spaces, and is extremely stable while handling large and heavy articles.

Abstract: A compound of formula (I) or its enantiomers or diastereoisomers thereof: wherein: A,; X, W, R1, Y; R3; and R4 are as defined herein. The compounds of the invention may be used as inhibitors of the papilloma virus E1-E2-DNA complex. The invention further provides a method of treating or preventing human papilloma virus infection.

Abstract: A compound of formula (I) or its enantiomers or diastereoisomers thereof: wherein: A, X, W, R1, Y; R3; and R4 are as defined herein. The compounds of the invention may be used as inhibitors of the papilloma virus E1-E2-DNA complex. The invention further provides a method of treating or preventing human papilloma virus infection.

Abstract: The use of a compound of formula (II): or its enantiomers or diastereoisomers thereof, or salts or pharmaceutically-acceptable esters thereof, in the treatment or prevention of a papilloma virus infection, particularly human papilloma virus in a mammal, wherein R11; X4; X5; X6; R13; R14; W; Z; Y; T; and R18 are defined herein. The present invention also provides novel compounds, pharmaceutical compositions and methods for using these compounds and compositions in the treatment or prevention of papilloma virus infection. More particularly, the present invention provides compounds, compositions and methods for inhibiting papilloma virus DNA replication by interfering with the E1-E2 protein-protein interaction essential for viral DNA replication.

Abstract: A method of creating a voice message is described. A dictated audio input is converted by automatic speech recognition to produce a structured text report that includes report fields with report field data extracted from the dictated audio input. A report message is created for transmission over an electronic communication system to a message recipient. The report message has message fields with message field data based on corresponding report field data. A message audio extract is automatically extracted from a portion of the dictated audio input and attached to the report message.

Abstract: An article handling apparatus for gripping and moving an article such as a large tire or other vehicular component of a mining, earthmoving or like vehicle. The article handling apparatus includes a base frame for movement of the apparatus over a substrate surface, and a handling frame for gripping the article, such as a tire. The apparatus has a pair of moveable arm members on the base frame, and a pair of moveable arm members on the handling frame. The apparatus can be compactly stored by contraction of the arms, can be manipulated through tight spaces, and is extremely stable while handling large and heavy articles.

Abstract: A compound of formula (I) or its enantiomers or diastereoisomers thereof: wherein: A, X, W, R1, Y; R3; and R4 are as defined herein. The compounds of the invention may be used as inhibitors of the papilloma virus E1-E2-DNA complex. The invention further provides a method of treating or preventing human papilloma virus infection.

Abstract: A method for stabilising reagents suitable for use in a nucleic acid amplification reaction has now been developed comprising: (i) preparing a reagent mixture comprising reagents suitable for use in a nucleic acid amplification reaction wherein the mixture comprises a polynucleotide polymerase; and (ii) drying the reagents; characterised in that said reagent mixture comprises from about 0.1% to about 50% of the final concentration of magnesium ions required to activate an amplification reaction. Reagents, reaction vessels, use of such reagents in a nucleic acid amplification reaction, and a method of conducting an amplification reaction using reagents so prepared are also disclosed herein.

Abstract: A network management apparatus and method for determining the topology of a network 1 is described. The present invention uses data relating to discovered devices on the network 1, typically network management address table data, to build a network tree. Due to the presence of unsupported or unmanaged connecting network devices, some branches of the resulting tree may not be resolved. In order to address this, for each unresolved branch of the network tree, the present invention attempts to determine the type of each of the discovered network devices on the branch, and if the type of every discovered network device on the branch is determined to be an endstation type, the present invention determines that an undiscovered connecting device is present on the branch.

Abstract: A telepresence system enhances the perception of presence of a remote person involved in a video conference. The system preferably has a two-way mirror, which is between the observer and the display device, positioned at an angle to reflect a backdrop surface. The backdrop surface, which is further away from the two-way mirror than the image plane of the image display device, appears superimposed in a position behind the image of a person from the remote location. The system preferably minimizes image distortion via an optical path for the camera line of sight that is substantially longer than the physical distance between the user and the camera. The system may be asymmetrical, in that one camera is on axis with the user's line of sight while the other camera is off axis with the user's line of sight.

Abstract: A method and system for creating and editing video and/or audio tracks is described. The method includes providing at least one artist, venue, and track available for selection and providing at least one clip associated with the at least one artist, venue, and track. The method also includes allowing a user to create a custom track from the at least one clip. The system includes a plurality of video cameras for recording a live performance at a plurality of positions. The system also includes at least one server for storing a plurality of video clips created from the plurality of video cameras and an application stored on the at least one server for allowing a user to access the plurality of video clips via the Internet. The clips (video, audio, or still images) may be edited in low-definition while the user's end product is a high-definition track.

Abstract: A crystallizable composition, comprising an human papillomavirus (HPV-11) E2 transactivation domain (TAD)-like polypeptide of SEQ ID NO. 2 complexed with an inhibitor L (sodium (2R,3R,4S,5R)-5-(3,4-dichlorophenyl)-5?-methyl-1?,3?-dioxo-4-({[4-(1,2,3-thiadiazol-4-yl)phenyl]amino}carbonyl)-1?,3?,4,5-tetrahydro-3H-spiro[furan-2,2?-indene]-3-carboxylate). The invention also provides a method for producing the crystallized HPV E2 TAD-inhibitor complex (HPV E2 TAD-L) comprising: a) mixing purified HPV E2 TAD, contained in a purification buffer, with solublized inhibitor L to generate a complex solution containing the HPV E2 TAD-L complex; and b) crystallizing the complex from a) in a crystallization buffer. The invention also provides a method for producing crystallized apo HPV E2 TAD, comprising: a) mixing apo HPV E2 TAD, contained in a purification buffer, with a crystallization buffer. X-ray crystal structure coordinates the HPV E2 TAD-L complex, are also provided, which define an inhibitor binding pocket.

Abstract: A system and method for locating objects such as people, pets, and personal articles is described. A transceiver is attached to the person, animal, or item to be tracked and a handheld locator device is employed to transmit a locator signal containing an address code to the transceiver. Upon receipt of a signal, the transceiver compares the address code contained in the locator signal with an address code stored in the transceiver. If the two codes are same, the transceiver sends a return signal back to the locator device. The locator device uses this return signal to determine the distance and/or direction of the transceiver from the user's location. The system allows a user to select from a multiple number of items to locate and allows multiple users to search for different articles within the same general area without interference.

Abstract: A compound of formula (I) or its enantiomers or diastereoisomers thereof: wherein: A, X, W, R1, Y; R3; and R4 are as defined herein. The compounds of the invention may be used as inhibitors of the papilloma virus E1-E2-DNA complex. The invention further provides a method of treating or preventing human papilloma virus infection.

Abstract: A compound of formula (I) or its enantiomers or diastereoisomers thereof: wherein: A,; X, W, R1, Y; R3; and R4 are as defined herein. The compounds of the invention may be used as inhibitors of the papilloma virus E1-E2-DNA complex. The invention further provides a method of treating or preventing human papilloma virus infection.

Abstract: A retroreflective studio background or backdrop material to which is applied an ink comprising retroreflective elements in a polymeric matrix, the ink being one which comprises comprises retroreflective elements and microbeads additional to said retroreflective elements, binder chemicals for attaching the retroreflective elements and microbeads to a substrate to which the ink is applied and a coupling agent for coupling the microbeads and cross-links the binder chemicals, the coupling agent being unreactive until the ink application process is carried out.