Patents by Inventor Peter X. Ma

Peter X. Ma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200230159
    Abstract: An apoptosis-mimicking structure includes a polymeric core. The polymeric core includes a polymer backbone. The polymer backbone includes or is modified with a functional group to directly or indirectly bond to an eat me signaling molecule. An eat me signaling molecule is bonded directly or indirectly to the functional group. Other structures include a scaffold and the apoptosis-mimicking structure immobilized on or incorporated into the scaffold.
    Type: Application
    Filed: August 7, 2018
    Publication date: July 23, 2020
    Inventors: Peter X. Ma, Laurie K. McCauley, Ming Dang
  • Patent number: 10513587
    Abstract: A self-integrating hydrogel includes a water-soluble polymer. The water-soluble polymer includes a repeating unit having at least one functional group that includes an oxygen atom, a sulfur atom, or a nitrogen atom, and a pendant chain covalently attached to the oxygen atom, the sulfur atom, or the nitrogen atom of the at least one functional group of the repeating unit. The pendant chain includes ureido-pyrimidinone.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: December 24, 2019
    Assignee: The Regents of the University of Michigan
    Inventors: Peter X. Ma, Sen Hou
  • Publication number: 20190307697
    Abstract: In an example of a method for making a pulsatile delivery device, one type of charges are generated on a polymeric layer, and charges opposite the one type of charges are generated on a delivery layer including a film forming material and a predetermined substance dispersed throughout the film forming material. The charged polymeric and delivery layers are placed into contact to form a bi-layer structure. A stack with at least two bi-layer structures is formed so that the polymeric layers and the delivery layers are alternating throughout the stack. The stack is sealed so that one of the polymeric layers remains exposed.
    Type: Application
    Filed: September 21, 2017
    Publication date: October 10, 2019
    Inventors: Peter X. Ma, Ming Dang, Laurie K. McCauley
  • Publication number: 20180094106
    Abstract: A self-integrating hydrogel includes a water-soluble polymer. The water-soluble polymer includes a repeating unit having at least one functional group that includes an oxygen atom, a sulfur atom, or a nitrogen atom, and a pendant chain covalently attached to the oxygen atom, the sulfur atom, or the nitrogen atom of the at least one functional group of the repeating unit. The pendant chain includes ureido-pyrimidinone.
    Type: Application
    Filed: September 29, 2017
    Publication date: April 5, 2018
    Inventors: Peter X. Ma, Sen Hou
  • Publication number: 20180021441
    Abstract: A hyperbranched polymer includes a hyperbranched, hydrophobic molecular core, respective low molecular weight polyethyleneimine chains attached to at least three branches of the hyperbranched, hydrophobic molecular core, and respective polyethylene glycol chains attached to at least two other branches of the hyperbranched, hydrophobic molecular core. Examples of the hyperbranched polymer may be used to form hyperbranched polyplexes, and may be included in DNA or RNA delivery systems.
    Type: Application
    Filed: September 29, 2017
    Publication date: January 25, 2018
    Inventors: Peter X. Ma, Xiaojin Zhang
  • Patent number: 9862807
    Abstract: A nanofibrous spongy microsphere includes porous walls that define an exterior of the microsphere and that extend through an interior of the microsphere. The porous walls consist of interconnected nanofibers and spaces formed between the interconnected nanofibers. A plurality of micro-scale pores are formed throughout the interior of the microsphere. Each of the micro-scale pores i) is partially defined by the porous walls, ii) has an interpore opening that opens to an adjacent micro-scale pores, and iii) has a diameter ranging from about 1 ?m to about 100 ?m. A total diameter of the microsphere ranges from about 5 ?m to about 1000 ?m.
    Type: Grant
    Filed: October 6, 2014
    Date of Patent: January 9, 2018
    Assignee: The Regents of the University of Michigan
    Inventors: Peter X. Ma, Zhanpeng Zhang
  • Publication number: 20160096941
    Abstract: A nanofibrous spongy microsphere includes porous walls that define an exterior of the microsphere and that extend through an interior of the microsphere. The porous walls consist of interconnected nanofibers and spaces formed between the interconnected nanofibers. A plurality of micro-scale pores are formed throughout the interior of the microsphere. Each of the micro-scale pores i) is partially defined by the porous walls, ii) has an interpore opening that opens to an adjacent micro-scale pores, and iii) has a diameter ranging from about 1 ?m to about 100 ?m. A total diameter of the microsphere ranges from about 5 ?m to about 1000 ?m.
    Type: Application
    Filed: October 6, 2014
    Publication date: April 7, 2016
    Inventors: Peter X. Ma, Zhanpeng Zhang
  • Patent number: 9187594
    Abstract: Nano-fibrous microspheres and methods for forming them are disclosed herein. In one embodiment the microsphere includes a plurality of nano-fibers aggregated together in a spherical shape; and a plurality of pores formed between at least some of the plurality of nano-fibers. The nano-fibers are formed of star-shaped polymers.
    Type: Grant
    Filed: February 9, 2011
    Date of Patent: November 17, 2015
    Assignee: The Regents of The University of Michigan
    Inventors: Peter X. Ma, Xiaohua Liu
  • Patent number: 9066997
    Abstract: Various embodiments of scaffolds are disclosed herein. In one embodiment, the scaffold includes a tubular polymeric structure, and a controlled gradient of solid-walled microtubules oriented radially or axially in the tubular polymeric structure. In another embodiment, the scaffold includes a nano-fibrous tubular polymeric structure, and an oriented and interconnected microtubular porous network formed in the nano-fibrous tubular polymeric structure. In still another embodiment, a composite scaffold is formed including a polymeric structure having an inner wall and an outer wall, and at least one electrospun layer positioned along at least one of the inner wall, or the outer wall, or in a middle of the porous polymeric structure.
    Type: Grant
    Filed: June 2, 2011
    Date of Patent: June 30, 2015
    Assignee: The Regents of The University of Michigan
    Inventors: Peter X. Ma, Haiyun Ma
  • Patent number: 8916185
    Abstract: A method for immobilizing micro-particles, nano-particles or combinations thereof onto a surface is disclosed. The method includes distributing the micro-particles, nano-particles or combinations thereof onto the surface. The surface and the particles are exposed to thermal treatment, vapor treatment or combinations thereof, thereby adhering at least some of the micro-particles, nano-particles or combinations thereof to the surface. Materials including such immobilized micro-particles, nano-particles or combinations thereof are also disclosed herein.
    Type: Grant
    Filed: February 27, 2008
    Date of Patent: December 23, 2014
    Assignee: The Regents of the University of Michigan
    Inventors: Peter X. Ma, Guobao Wei
  • Patent number: 8709464
    Abstract: A porous object includes a porous material having internal pore surfaces and external pore surfaces. Releasing material encapsulated biomolecules are immobilized on at least one of the internal pore surfaces, at least one of the external pore surfaces, or combinations thereof.
    Type: Grant
    Filed: January 10, 2008
    Date of Patent: April 29, 2014
    Assignee: The Regents of the University of Michigan
    Inventors: Peter X. Ma, Guobao Wei, William V. Giannobile, Qiming Jin
  • Patent number: 8623397
    Abstract: A delivery device includes a hollow container, and a plurality of biodegradable and/or erodible polymeric layers established in the container. A layer including a predetermined substance is established between each of the plurality of polymeric layers, whereby degradation of the polymeric layer and release of the predetermined substance occur intermittently. Methods for forming the device are also disclosed herein.
    Type: Grant
    Filed: April 13, 2008
    Date of Patent: January 7, 2014
    Assignee: The Regents of The University of Michigan
    Inventors: Peter X. Ma, Xiaohua Liu, Laurie McCauley
  • Patent number: 8568769
    Abstract: Porous materials and methods for forming them are disclosed. One method for immobilizing micro-particles and/or nano-particles onto internal pore surfaces and/or external pore surfaces of porous materials includes suspending the micro-particles and/or nano-particles in a liquid adapted to swell, soften, and/or deform either the porous materials and/or the particles, thereby forming a liquid-particle suspension. The method further includes adding the suspension to the porous materials; and removing the liquid, thereby forming the porous materials having the micro-particles and/or nano-particles immobilized on the internal pore surfaces and/or the external pore surfaces.
    Type: Grant
    Filed: August 2, 2012
    Date of Patent: October 29, 2013
    Assignee: The Regents of The University of Michigan
    Inventors: Peter X. Ma, Guobao Wei
  • Patent number: 8445588
    Abstract: A water soluble copolymer includes first and second hydrophilic block segments or graft chains. The first hydrophilic block segment or graft chain contains cyclodextrin groups in at least a majority of its repeating units, and the second hydrophilic block segment or graft chain contains repeating units other than cyclodextrin groups. The first and second block segments or graft chains are covalently linked.
    Type: Grant
    Filed: August 18, 2009
    Date of Patent: May 21, 2013
    Assignee: The Regents of The University of Michigan
    Inventors: Peter X. Ma, Jianxiang Zhang
  • Publication number: 20120308825
    Abstract: Nano-fibrous microspheres and methods for forming them are disclosed herein. In one embodiment the microsphere includes a plurality of nano-fibers aggregated together in a spherical shape; and a plurality of pores formed between at least some of the plurality of nano-fibers. The nano-fibers are formed of star-shaped polymers.
    Type: Application
    Filed: February 9, 2011
    Publication date: December 6, 2012
    Inventors: Peter X. Ma, Xiaohua Liu
  • Publication number: 20120301516
    Abstract: Porous materials and methods for forming them are disclosed. One method for immobilizing micro-particles and/or nano-particles onto internal pore surfaces and/or external pore surfaces of porous materials includes suspending the micro-particles and/or nano-particles in a liquid adapted to swell, soften, and/or deform either the porous materials and/or the particles, thereby forming a liquid-particle suspension. The method further includes adding the suspension to the porous materials; and removing the liquid, thereby forming the porous materials having the micro-particles and/or nano-particles immobilized on the internal pore surfaces and/or the external pore surfaces.
    Type: Application
    Filed: August 2, 2012
    Publication date: November 29, 2012
    Inventors: Peter X. Ma, Guobao Wei
  • Patent number: 8268344
    Abstract: Porous materials and methods for forming them are disclosed. One method for immobilizing micro-particles and/or nano-particles onto internal pore surfaces and/or external pore surfaces of porous materials includes suspending the micro-particles and/or nano-particles in a liquid adapted to swell, soften, and/or deform either the porous materials and/or the particles, thereby forming a liquid-particle suspension. The method further includes adding the suspension to the porous materials; and removing the liquid, thereby forming the porous materials having the micro-particles and/or nano-particles immobilized on the internal pore surfaces and/or the external pore surfaces.
    Type: Grant
    Filed: April 25, 2006
    Date of Patent: September 18, 2012
    Assignee: The Regents of The University of Michigan
    Inventors: Peter X. Ma, Guobao Wei
  • Publication number: 20110311746
    Abstract: Various embodiments of scaffolds are disclosed herein. In one embodiment, the scaffold includes a tubular polymeric structure, and a controlled gradient of solid-walled microtubules oriented radially or axially in the tubular polymeric structure. In another embodiment, the scaffold includes a nano-fibrous tubular polymeric structure, and an oriented and interconnected microtubular porous network formed in the nano-fibrous tubular polymeric structure. In still another embodiment, a composite scaffold is formed including a polymeric structure having an inner wall and an outer wall, and at least one electrospun layer positioned along at least one of the inner wall, or the outer wall, or in a middle of the porous polymeric structure.
    Type: Application
    Filed: June 2, 2011
    Publication date: December 22, 2011
    Applicant: The Regents of the University of Michigan
    Inventors: Peter X. Ma, Haiyun Ma
  • Patent number: 7993738
    Abstract: Modified porous materials are disclosed having interconnected, complexly shaped three-dimensional surfaces. The modification is accomplished by crosslinking the three-dimensional surfaces or by incorporating, in situ, an inorganic material onto or into three-dimensional surfaces. The porous materials are macro structures including at least one of nano-features, micro-features, and combinations thereof. The modifying accomplishes changing surface properties of the porous materials, changing the three-dimensional surfaces, and/or rendering the porous materials substantially stable in a predetermined environment.
    Type: Grant
    Filed: January 25, 2008
    Date of Patent: August 9, 2011
    Assignee: The Regents of the University of Michigan
    Inventors: Peter X. Ma, Xiaohua Liu
  • Publication number: 20100048734
    Abstract: A water soluble copolymer includes first and second hydrophilic block segments or graft chains. The first hydrophilic block segment or graft chain contains cyclodextrin groups in at least a majority of its repeating units, and the second hydrophilic block segment or graft chain contains repeating units other than cyclodextrin groups. The first and second block segments or graft chains are covalently linked.
    Type: Application
    Filed: August 18, 2009
    Publication date: February 25, 2010
    Inventors: Peter X. Ma, Jianxiang Zhang