Patents by Inventor Peter X. Shaw

Peter X. Shaw has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for diagnosing, imaging and treating atherosclerotic disease
    Patent number: 7556927
    Abstract: The invention provides a novel human Mab Fab, cloned by phage display, and its use in diagnostic and therapeutic methods. In particular the invention provides a method for analyzing the OxLDL components of atherosclerotic plaques in vivo and a means to determine their relative pathology. As the method is based on a human Fab rather than a mouse Mab, the progress or regression of the disease may be monitored over time. The antibody may also be used for the analysis of surgical or serum samples ex vivo for the presence of OxLDL. The antibody may also be used to target therapeutic agents to the site of atherosclerotic plaques or may have use as a therapeutic agent itself.
    Type: Grant
    Filed: November 11, 2003
    Date of Patent: July 7, 2009
    Assignee: The Regents of the University of California
    Inventors: Joseph L. Witztum, Sotirios Tsimikas, Wulf Palinski, Peter X. Shaw
  • Reagents for diagnosing, imaging and treating atherosclerotic disease
    Publication number: 20040120893
    Abstract: The invention provides a novel human Mab Fab, cloned by phage display, and its use in diagnostic and therapeutic methods. In particular the invention provides a method for analyzing the OxLDL components of atherosclerotic plaques in vivo and a means to determine their relative pathology. As the method is based on a human Fab rather than a mouse Mab, the progress or regression of the disease may be monitored over time. The antibody may also be used for the analysis of surgical or serum samples ex vivo for the presence of OxLDL. The antibody may also be used to target therapeutic agents to the site of atherosclerotic plaques or may have use as a therapeutic agent itself.
    Type: Application
    Filed: November 12, 2003
    Publication date: June 24, 2004
    Inventors: Joseph L. Witztum, Sotirios Tsimikas, Wulf Palinski, Peter X. Shaw
  • Methods for diagnosing, imaging and treating atherosclerotic disease
    Publication number: 20040071632
    Abstract: The invention provides a novel human Mab Fab, cloned by phage display, and its use in diagnostic and therapeutic methods. In particular the invention provides a method for analyzing the OxLDL components of atherosclerotic plaques in vivo and a means to determine their relative pathology. As the method is based on a human Fab rather than a mouse Mab, the progress or regression of the disease may be monitored over time. The antibody may also be used for the analysis of surgical or serum samples ex vivo for the presence of OxLDL. The antibody may also be used to target therapeutic agents to the site of atherosclerotic plaques or may have use as a therapeutic agent itself.
    Type: Application
    Filed: November 11, 2003
    Publication date: April 15, 2004
    Inventors: Joseph L. Witztum, Sotirios Tsimikas, Wulf Palinski, Peter X. Shaw
  • Reagents and methods for diagnosing, imaging and treating atherosclerotic disease
    Patent number: 6716410
    Abstract: The invention provides a novel human Mab Fab, cloned by phage display, and its use in diagnostic and therapeutic methods. In particular the invention provides a method for analyzing the OxLDL components of atherosclerotic plaques in vivo and a means to determine their relative pathology. As the method is based on a human Fab rather than a mouse Mab, the progress or regression of the disease may be monitored over time. The antibody may also be used for the analysis of surgical or serum samples ex vivo for the presence of OxLDL. The antibody may also be used to target therapeutic agents to the site of atherosclerotic plaques or may have use as a therapeutic agent itself.
    Type: Grant
    Filed: October 26, 2000
    Date of Patent: April 6, 2004
    Assignee: The Regents of the University of California
    Inventors: Joseph L. Witztum, Sotirios Tsimikas, Wulf Palinski, Peter X. Shaw