Abstract: Described herein are chimeric Newcastle disease viruses comprising a packaged genome comprising a transgene encoding interleukin-12. The chimeric Newcastle disease viruses and compositions thereof are useful in combination with an antagonist of programmed cell death protein 1 (“PD-1”) or a ligand thereof in the treatment of cancer. In particular, described herein are methods for treating cancer comprising administering the chimeric Newcastle disease viruses in combination with an antagonist of PD-1 or a ligand thereof, wherein the chimeric Newcastle disease virus comprises a packaged genome comprising a transgene encoding interleukin-12.

Abstract: There is provided a system configured to receive data associated with a vehicle operating within an environment; generate, based at least in part on the data, a graph comprising a plurality of nodes, a node of the plurality associated with one or more of a vehicle operating in the environment, a road feature, an additional vehicle, or a pedestrian; input the graph into a self-supervised machine learned model comprising an encoder, wherein the machine learned model is trained to output a representation associated with the node; receive, from the self-supervised machine learned model, a representation associated with the node; and transmit the representation to a downstream machine learned model trained to output control data based at least in part on the representation, wherein the control data is configured to control the vehicle or another vehicle.

Abstract: Embodiments of the present disclosure provide a method for scheduling a plurality of data packets from an industrial controller to one or more industrial devices over a wireless communication network. The method includes receiving, from the industrial controller, traffic pattern characteristics associated with the plurality of data packets intended to the one or more industrial devices. The method includes receiving, from a network node in the wireless communication network, timing information related to a plurality of radio resources for transmission of the plurality of data packets. The method includes scheduling the plurality of data packets on the plurality of radio resources using the traffic pattern characteristics and the timing information related to the plurality of radio resources.

Abstract: Systems and methods for assessing a flow of fluids suctioned from a patient. The flow of fluids may be divided according to a flow division ratio. An image of a first portion of the fluids may be evaluated to determine an estimated blood component quantity as a representative fraction of the flow of fluids. An intermittent estimate of blood loss may be determined based on the flow division ratio and the estimated blood component quantity, and a total estimate of blood loss updated based on the intermittent estimate. The representative fraction is projected or extended to be an estimated blood component quantity of the second portion of the fluids that bypasses the receptacle. The images may be continuously captured with a camera, and a fluid level of the fluids with a receptable may be continuously monitored. The total estimate of blood loss may be displayed in real-time on a display.

Abstract: The present disclosure generally relates to the treatment of subjects having osteoarthritis or at risk of developing osteoarthritis by administering a Procollagen Galactosyl Transferase 2 (COLGALT2) inhibitor to the subject.

Abstract: According to an aspect of the present disclosure, there is provided a circuit board system including: a main board having a top side and a bottom side, wherein the main board has at least one cavity on its top side; a printed circuit board, PCB having a top side and a bottom side; and at least one first electronic component arranged on the top side of the PCB, and at least one second electronic component arranged on the bottom side of the PCB, wherein the PCB is arranged on the top side of main board, and wherein the at least one second electronic component on the bottom side of the PCB extends into the cavity on the top side of the main board.

Abstract: Provided is a method executed by one or more computers, the method including acquiring a user decentralized identifier for identifying a signatory who provides a handwritten signature to an electronic document, calculating a hash value of a document file representing the electronic document provided with the handwritten signature by the signatory, and generating a certificate including the user decentralized identifier and the hash value of the document file.

Abstract: Systems and methods are provided for FAA-certified avionics devices to safely interface with non-certified mobile telecommunications devices before, during, and after flight. Data transmitted to the certified devices do not affect functionality of the certified device unless and until a user acknowledges and/or confirms the data on the certified device. Thus, the integrity of the certified device is maintained.

Abstract: A detector for a plasma measurement system, where the detector includes an insulating substrate including a cavity; a conductive plate spanning an entrance to the cavity; a first aperture through the conductive plate; an iris diaphragm including movable blades around a second aperture, the second aperture being aligned to the first aperture; an ion current collector disposed in the cavity, the iris diaphragm being disposed between the ion current collector and the conductive plate; and a rotatable gear coupled to the movable blades of the iris diaphragm.

Abstract: 3D metrology techniques are disclosed for determining a changing topography of a substrate processed in an additive manufacturing system. Techniques include fringe scanning, simultaneous fringe projections, interferometry, and x-ray imaging. The techniques can be applied to 3D printing systems to enable rapid topographical measurements of a 3D printer powder bed, or other rapidly moving, nearly continuous surface to be tested. The techniques act in parallel to the system being measured to provide information about system operation and the topography of the product being processed. A tool is provided for achieving higher precision, increasing throughput, and reducing the cost of operation through early detection and diagnosis of operating problems and printing defects. These techniques work well with any powder bed 3D printing system, providing real-time metrology of the powder bed, the most recently printed layer, or both without reducing throughput.

Abstract: The invention generally contemplates homogeneous solid blends of at least one oil and at least one polymer, and uses thereof.

Abstract: The current invention relates to a filtration membrane envelope (3) comprising a 3D spacer fabric (7) having an upper and lower surface (9, 10) tied together and spaced apart by monofilament threads (11), said 3D spacer fabric is interposed between two membrane layers, and forming a permeate channel (12), wherein said membrane layers are cast respectively on said upper and lower fabric surface of said 3D spacer fabric and wherein said upper and lower fabric surfaces are at least partially embedded in said membrane layers, thereby forming an upper and lower anchorage section (13, 14), characterized in that said anchorage section have a minimal thickness of 100 micron.

Abstract: An atomization unit (1) for atomizing metal melts, in particular for powder-metallurgical purposes, includes a crucible (2) having a base outlet (4). A melt nozzle (16) is arranged below the base outlet (4) and a gas nozzle (9) is preferably arranged concentrically with respect to the melt nozzle (16). The melt nozzle (16) is formed in multiple parts and comprises a casing body along with a nozzle core (17). The nozzle core (17) passes through a conical seat within the casing body.

Abstract: Several methods of automatically measuring blood pressure are disclosed, which may include applying a sphygmometer cuff coupled to a transducer or detector capable of detecting an imaging signal to an extremity of a patient. The detector may include an ultrasonic or photoacoustic means of determining blood pressure. A device for automatically measuring blood pressure utilizing several methods and having a variety of configurations for obtaining blood pressure data from a patient is also disclosed.

Abstract: A method for treating Chronic Obstructive Pulmonary Disease (COPD) or chronic bronchitis to alleviate the discomforts of breathing by using non-thermal electroporation energy to ablate diseased portions of the lung including the bronchus, airways and alveoli which, in effect, opens the restrictive diseased portions thereby maximizing the overall surface area thereof causing improved airflow and uninhibited breathing.

Abstract: The invention relates to a ventilation, heating and/or air conditioning device for a passenger compartment of a vehicle, the device having at least one air inlet, at least one air outlet, the device having at least a first heat exchanger, a second heat exchanger and a third heat exchanger, at least a part of the device being separated in a left zone and a right zone by a partition wall. The device includes at least one opening located downstream the third heat exchanger so that at least part of the flow of air present in one of the zones fluidly communicates with the other zone.

Abstract: A flexible tubing guidance device is disclosed. In accordance with some embodiments, the disclosed device may include a plurality of internal roller elements to facilitate passing of tubing through the bore of a block body. In accordance with some embodiments, the disclosed device also may include a clamping mechanism to provide a clamping force for holding the tubing in place. The clamping mechanism may be mounted on an exterior of the block body and may employ a drive element that provides a camming action for several jaw elements that contact the exterior of the tubing. In accordance with some embodiments, the disclosed device may be utilized, for example, for accurately aligning and/or measuring of flexible tubing for cutting thereof. In accordance with some embodiments, the disclosed device may be configured to minimize (or otherwise reduce) the likelihood of bunching or jamming of the flexible tubing during processing thereof.

Abstract: A coolant distribution manifold assembly for use in a module or circuit pack of an optical networking system, including: a body defining a main inlet port at one end, a main outlet port at another end, and a plurality of cooling plate inlet ports and cooling plate outlet ports disposed between the main inlet port and the main outlet port; where the body further defines an upper internal plenum and a lower internal plenum each coupled to one of the main inlet port and the plurality of cooling plate inlet ports and the main outlet port and the plurality of cooling plate outlet ports. Optionally, the upper internal plenum and the lower internal plenum each have a variable cross-sectional area along a length of the body between the main inlet port and the main outlet port.

Abstract: A biopsy system driver includes a motor having a rotatable output shaft, a support structure, a drive shaft, an elongate lead screw and a biopsy instrument drive member. The drive shaft is rotatably coupled to the support structure and includes or is otherwise operatively connected to the motor output shaft such that activation of the motor rotates the drive shaft. The elongate lead screw is coupled to the drive shaft such that rotation of the drive shaft rotates the lead screw about an axis of the lead screw. The lead screw is axially translatable relative to the drive shaft and to the support structure. The biopsy instrument drive member is threadably coupled to the lead screw such that rotation of the lead screw causes axial translation of one of the lead screw and biopsy instrument drive member relative to the other one and to the support structure.

Abstract: A method of treating Alcohol Use Disorder (AUD), Substance Use Disorder (SUD), tobacco use, pain, or proinflammatory disorders comprising: providing a subject with an effective amount of a modified tetracycline or derivative thereof to ameliorate or eliminate the AUD, SUD, tobacco use, pain, or proinflammatory disorder, and wherein the modified tetracycline or derivative thereof has reduced binding to a microbial ribosome and has the formula: wherein R1 is acetyl, R2 is OH or acetyl, R3 is acetyl, R4 is H or acetyl, and R5 is acetyl.