Abstract: The present disclosure relates to compounds that are capable of penetrating the blood brain barrier to modulate the activity of EGFR tyrosine kinase. The disclosure further relates to methods of treating glioblastoma and other EGFR-mediated cancers, such as those that have been determined to have altered glucose metabolism in the presence of inhibitors. The present disclosure also provides methods of administering to a subject a glucose metabolism inhibitor and a cytoplasmic p53 stabilizer.

Abstract: A system and method for contact-based spatial frequency domain imaging. A medium to be imaged is contacted by a sheet comprising an array of lighting elements generating illumination light patterns illuminating the medium, and comprising an array of sensor elements measuring spatially resolved images of resulting light patterns reflected back after interaction of the illumination light patterns with the medium. The lighting elements generate illumination light patterns that are spatially modulated in light intensity along a surface of the illuminated medium according to a respective different spatial frequency. A set of spatially modulated images is determined based on the measured resulting light patterns caused by the different illumination light patterns. An image of the medium can be generated based on a combination of the spatially modulated images.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for controlling an agent interacting with an environment. In one aspect, a method comprises: receiving one or more observations of an environment; receiving an input text sequence that describes a task to be performed by a robot in the environment; generating an encoded representation of the input text sequence in an embedding space; generating a corresponding encoded representation of each of the one or more observations in the embedding space; generating a sequence of input tokens that comprises the encoded representation of the input text sequence and the corresponding encoded representation of each observation; processing the sequence of input tokens using a language model neural network to generate an output text sequence that comprises high-level natural language instructions; and determining, from the high-level natural language instructions, one or more actions to be performed by the robot.

Abstract: An implantable apparatus for treating reflux disease in a human or animal mammal patient, the implantable apparatus being configured to be fixated to the stomach of the patient and comprising two or more implantable movement restriction device segments, wherein each implantable movement restriction device segment is provided with at least one assembly element that fits with at least one assembly element of another of said two or more implantable movement restriction device segment, so the two or more implantable movement restriction device segments by said assembly elements can be assembled into an implantable assembled movement restriction device.

Abstract: Aptamers, biosensors and aptamer-based biosensors for monitoring cortisol and other hormones are provided. Methods of optimizing aptamers for biosensing applications are also provided. Aptamers have been optimized to undergo a conformational change when binding, or unbinding, cortisol at physiologically relevant concentrations. These aptamers can be incorporated into aptamer-based sensors for real-time, continuous monitoring of cortisol.

Abstract: A method for processing a CFET device is provided that includes: (i) forming a fin structure that includes a first layer stack below a second layer stack, the first layer stack including a first channel layer and the second layer stack including a second channel layer; (ii) forming a set of gate structures around the fin structure and perpendicular to the fin structure and spaced apart from each other, the set of gate structures covering the fin structure in channel regions and exposing the fin structure in fin cut regions that alternate with the channel regions; (iii) at least partially removing the fin structure in the fin cut regions to form preliminary fin cuts; and (iv) forming a cover layer which partially covers side walls of recess(es) formed by the preliminary fin cuts

Abstract: Provided herein is a non-invasive biometric sensing and monitoring device that may be employed in a non-invasive method with the potential for comprehensive analysis and data processing. The non-invasive biometric sensing and monitoring device may be employed for determining a characteristic of a state of a wearer using the device based on a value of a biomolecule within a body tissue of the user. The device may include a housing for retaining one or more components of the biometric device. The components may may include a substrate, such as a printed circuit board, and may further include one or more of an signal generator, a microwave structure based sensor unit, a filter unit, a receiver component, an analog to digital converter, a control unit, one or more buffers, a communications module and controller as well as an analytics system.

Abstract: An aerodynamic system for a vehicle that includes a structure. The structure includes a body that defines an underbody. The vehicle includes an assembly that moves relative to the body. A panel system is coupled with the underbody and includes an aerodynamic panel defining an opening and a reactive panel that closes the opening. The aerodynamic panel is coupled with the body at the underbody. The reactive panel moves in response to contact by the assembly and returns to close the opening when released by the assembly.

Abstract: Disclosed herein is a composition including (i) at least one polyurethane (1) carrying ethylenically unsaturated groups and COOH groups, which COOH groups are at least partly in the form of a salt group thereof, which polyurethane is obtained by the reaction of at least one polyol (B1) carrying at least one COOH group, at least monoalcohol (B2) carrying at least one ethylenically unsaturated group, optionally at least polyol (B3) carrying at least one ethylenically unsaturated group and no COOH group, at least one polyol (B4) carrying no ethylenically unsaturated group and no COOH group, at least one polyisocyanate (A1) carrying at least one ethylenically unsaturated group, optionally at least one polyisocyanate (A2) carrying no ethylenically unsaturated group, and optionally at least one compound (C1) carrying at least one NH2 group and no OH group.

Abstract: Systems and methods for a chatbot authentication system and process that may utilize a large language model (LLM) and state of the art generative natural language processing (NLP) to generate and/or interpret user answers questions generated based on comprehensive known data about the user. The questions can include skills-based and/or knowledge-based queries which may be open ended questions. The user answers provided may be evaluated for accuracy and completeness. Iterative and/or follow-up questions may be generated and posed to allow the user to provide clarifications or additional details. By virtue of the LLM and NLP, the systems and methods disclosed herein may understand the semantical meaning of the answers provided by the user, which can enable a more accurate, user friendly and secure authentication process.

Abstract: The present disclosure relates to a positive pressure breathing circuit and a method for ventilating a patient. The breathing circuit can be used in any type of pressurized breathing therapy including, for example, continuous positive air (way) pressure (CPAP) therapy and bilevel positive air pressure therapy where the inspiratory and expiratory pressures differ.

Abstract: The present technology is directed to adjustable interatrial shunting systems that selectively control blood flow between the left atrium and the right atrium of a patient. The adjustable interatrial devices include a shunting element having an outer surface configured to engage native tissue and an inner surface defining a lumen that enables blood to flow from the left atrium to the right atrium when the system is deployed across the septal wall. The systems can include an actuation assembly for selectively adjusting a geometry of the lumen and/or a geometry of a lumen orifice to control the flow of blood through the lumen.

Abstract: A system includes a housing including a front panel, a rear panel, an upper panel, and a lower panel. The system includes a first circuit board or substrate, at least one data processor coupled to the first circuit board or substrate and configured to process data, and at least one optical module coupled to the first circuit board or substrate. Each optical module is configured to perform at least one of (i) convert input optical signals to electrical signals that are provided to the at least one data processor, or (ii) convert electrical signals received from the at least one data processor to output optical signals. The system includes at least one inlet fan mounted near the front panel and configured to increase an air flow across a surface of at least one of (i) the at least one data processor, (ii) a heat dissipating device thermally coupled to the at least one data processor, (iii) the at least one optical module, or (iv) a heat dissipating device thermally coupled to the at least one optical module.

Abstract: Various aspects of the present disclosure generally relate to wireless communication. In some aspects, a user equipment (UE) may transmit an indication of a set of frequency bands supported for uplink transmission switching between frequency bands, the frequency bands including one or more bandwidth parts. The UE may transmit an indication of a subset of the set of frequency bands, the subset supported for dynamic uplink transmission switching between the frequency bands. The UE may transmit one or more uplink communications via one or more frequency bands of the subset of the set of frequency bands. Numerous other aspects are described.

Abstract: An ankle stretch orthosis includes a foot assembly having a ball support assembly adjustably mounted on a foot plate. The foot assembly includes an adjustment mechanism for selectively adjusting a position of ball support assembly relative to the foot plate to align the ball support assembly with a ball portion of a foot that is one of supinated and pronated.

Abstract: An ingestible device (200), comprising: a housing (210, 220) comprising a stop geometry (228) at an exit hole (224); a tissue penetrating member (230) and an actuator that comprises: a pushing portion (260) configured for axial movement from a first to a second position, the pushing portion configured to move the tissue penetrating member from within the housing to a lodged position in tissue, and a holder portion (270) coupled with the pushing portion (260) for initial axial movement with the pushing portion. In the first position the holder portion releasably holds the tissue penetrating member (230) in axial retaining engagement. As the pushing portion (260) moves towards the second position, the tissue penetrating member (230) moves through the exit hole (224) until the holder portion (270) enters into engagement with the stop geometry (228). The pushing portion (260) moves further to release and advance the tissue penetrating member (230).

Abstract: A method is described for performing a wipe-out and verification of a plurality of non-volatile memory (NVM) cells. The method includes performing an operation to set all the plurality of NVM cells to a single state. The single state may be one of a conducing or non-conducting state depending on the NVM architecture. After the operation to set the cells to the single state is complete, the verification is performed. In the verification operation, all cells of the plurality of NVM cells are set to the single state by performing a single read operation on the plurality of NVM cells. Detection of one of a conducting or non-conducting path through the plurality of NVM cells is used to verify if all cells of the NVM array had their contents wiped out. A notification is provided in response to all cells not being set to the single known state.

Abstract: A vertical power semiconductor device includes a silicon carbide (SiC) semiconductor body having opposite first and second surfaces. The SiC semiconductor body includes a transistor cell area including gate structures, a gate pad area, and an interconnection area electrically coupling a gate electrode of the gate structures and a gate pad of the gate pad area via a gate interconnection. The vertical power semiconductor device further includes a sensor electrode and a first interlayer dielectric having a first interface to the sensor electrode and a second interface to at least one of the gate electrode or the gate interconnection. A conduction band offset at the first interface ranges from 1 eV to 2.5 eV. The vertical power semiconductor device further includes a second interface to at least one of the gate electrode or the gate interconnection. The second interlayer dielectric laterally adjoins to the first interlayer dielectric.

Abstract: An example system includes a memory device; and a processing device, operatively coupled to the memory device, to perform operations, including: programming a plurality of pages of the memory device; adjusting a program verify voltage associated with the plurality of pages; responsive to determining that a first error rate of a first page of the plurality of pages exceeds a second error rate of a second page of the plurality of pages, performing a recovery operation on the first page to produce recovered data; and storing the recovered data on the memory device.

Abstract: The present disclosure pertains to medical devices that comprise a stent body having two ends, a central region therebetween, and comprising structural elements extending around the stent body and a covering material disposed over the stent body, the covering material covering only a portion of the stent body, in which the covering material is provided with a plurality of openings that provide areas where the stent body is not covered by the covering material. The present disclosure further pertains to medical apparatuses that comprise such medical devices and methods of treatment using such medical devices.