Abstract: Systems and methods are provided for adaptive data replication. A first data object is stored. One or more first network characteristics of a communication network are detected. A first replication mode is triggered (e.g., a single-master replication mode) based on the one or more first network characteristics of the communication network. The single-master replication may be configured to facilitate real-time synchronizations (e.g., for critical updates). One or more second network characteristics of the communication network are detected. A second replication mode (e.g., a multi-master replication mode) is triggered based on the one or more second network characteristics. The second replication may be configured to facilitate a delayed synchronization (e.g., for non-critical updates) of the first data object and the second data object using the second update file.

Abstract: Disclosed are methods of isolating paired T cell receptor (TCR) alpha and beta chain sequences, or an antigen-binding portion thereof. Also disclosed are methods of automatically identifying the TCR alpha and beta chain V segment sequences and CDR3 sequences of a TCR having antigenic specificity for a mutated amino acid sequence encoded by a cancer-specific mutation. Methods of preparing a population of cells that express paired TCR alpha and beta chain sequences, or an antigen-binding portion thereof, are also disclosed. Isolated pairs of TCR alpha and beta chain sequences and isolated populations of cells prepared by the methods are also disclosed.

Abstract: Described herein are systems for roof scan using an unmanned aerial vehicle. For example, some methods include capturing, using an unmanned aerial vehicle, an overview image of a roof of a building from above the roof; presenting a suggested bounding polygon overlaid on the overview image to a user; determining a bounding polygon based on the suggested bounding polygon and user edits; based on the bounding polygon, determining a flight path including a sequence of poses of the unmanned aerial vehicle with respective fields of view at a fixed height that collectively cover the bounding polygon; fly the unmanned aerial vehicle to a sequence of scan poses with horizontal positions matching respective poses of the flight path and vertical positions determined to maintain a consistent distance above the roof; and scanning the roof from the sequence of scan poses to generate a three-dimensional map of the roof.

Abstract: In some examples, an unmanned aerial vehicle (UAV) may include one or more processors configured to capture, with one or more image sensors, and while the UAV is in flight, a plurality of images of a target. The one or more processors may compare a first image of the plurality of images with a second image of the plurality of images to determine a difference between a current frame of reference position for the UAV and an estimate of an actual frame of reference position for the UAV. In addition, the one or more processors may determine, based at least on the difference, and while the UAV is in flight, an update to a three-dimensional model of the target.

Abstract: Methods, apparatus, and systems for load control for cooling systems are provided. Coolant flows through a plurality of cooling units in a cooling system. The coolant flow is halted for each cooling unit that is undergoing a defrost cycle. Each cooling unit is configured to start a first defrost cycle at a random time within a predetermined time range after the cooling unit is started or powered on. After the first random start defrost cycle, a regular periodic defrost cycle may be maintained. Thus, the cooling units may be powered on simultaneously while still providing desynchronized defrost cycles, enabling the cooling system to maintain adequate coolant flow and heat load to avoid deleterious stop and restart cycles.

Abstract: A receiver for a refrigeration system includes an enclosure with an inlet for liquid refrigerant at a first end and an outlet for the liquid refrigerant at a second end. A heat exchanger with an inlet and an outlet for refrigerant vapor is surrounded by the enclosure. The heat exchanger includes baffles so that alternatingly positioned flow passages are positioned on opposing sides of the enclosure.

Abstract: Methods, apparatus, and systems for load control for cooling systems are provided. Coolant flows through a plurality of cooling units in a cooling system. The coolant flow is halted for each cooling unit that is undergoing a defrost cycle. Each cooling unit is configured to start a first defrost cycle at a random time within a predetermined time range after the cooling unit is started or powered on. After the first random start defrost cycle, a regular periodic defrost cycle may be maintained. Thus, the cooling units may be powered on simultaneously while still providing desynchronized defrost cycles, enabling the cooling system to maintain adequate coolant flow and heat load to avoid deleterious stop and restart cycles.

Abstract: A receiver for a refrigeration system includes an enclosure with an inlet for liquid refrigerant at a first end and an outlet for the liquid refrigerant at a second end. A heat exchanger with an inlet and an outlet for refrigerant vapor is surrounded by the enclosure.

Abstract: A space-saving cooling system for an aircraft may include an evaporator in an enclosure with an accumulation region in the enclosure for a liquid mixture of liquid refrigerant and lubricating oil. Space saving may be achieved through a combining of evaporator functions and accumulator functions in a single enclosure. A heat exchanger may be interposed between the evaporator and the compressor for heating refrigerant emerging from the evaporator so that liquid refrigerant does not reach an inlet of the compressor.

Abstract: A charge valve system includes a valve fitting housing a valve and a cap sealing the fluid from escaping the charge valve system. The valve fitting may include a fitting exterior surface diameter. The cap may include an inner sidewall diameter greater than the fitting exterior surface diameter so that the cap inner sidewall may be spaced from the fitting exterior surface. In some embodiments, the cap inner sidewall may be slid over the valve fitting into compressed engagement sealing the cap over the valve fitting.

Abstract: A connection system for carrying a refrigerant may provide a hybrid redundancy in sealing a refrigerant flow from the surround system environment. The connection system may include a first sealing ring of a first type and a second sealing ring of a second type positioned downstream from the first sealing ring. In some embodiments, the first sealing ring may be in a groove positioned around the outside diameter of a male fitting. The second sealing ring may be positioned at an interface between the male fitting and a female fitting. In some embodiments, flanges of each fitting define the interface so that the second sealing ring may be positioned between the flanges of each fitting. The second sealing ring may be selected from a material that has a wider range of operating temperature than the first sealing ring so that in the event of failure in the first sealing ring, the second sealing ring may prevent leakage.

Abstract: A refrigerant distribution system has a plurality of chambers formed inside a refrigerant distribution plate, each of the plurality of chambers extending from one end of the refrigerant distribution plate into the refrigerant distribution plate; and a plurality of holes formed in each of the plurality of chambers, the plurality of holes fluidly communicating each of the plurality of chambers with an outside of the refrigerant distribution place. The evaporator may be oriented such that the refrigerant flows horizontally with respect to gravity. The present invention may improve the thermal performance of the evaporator while the evaporator is oriented sub-optimally. Often, with horizontal flow through an evaporator, the refrigerant phases, liquid and vapor, may separate in the manifold, resulting in poor distribution of refrigerant in the evaporator core. The refrigerant distribution plate of the present invention evenly distributes the refrigerant in the core.

Abstract: An O-ring shield system and method of protecting O-rings in a high pressure refrigerant system are disclosed. The system may include first and second pipes coupled together. An O-ring may be disposed on one of the pipes. A compressible shield ring may be positioned upstream a flow of refrigerant from the O-ring.

Abstract: A space-saving cooling system for an aircraft may include an evaporator in an enclosure with an accumulation region in the enclosure for a liquid mixture of liquid refrigerant and lubricating oil. Space saving may be achieved through a combining of evaporator functions and accumulator functions in a single enclosure. A heat exchanger may be interposed between the evaporator and the compressor for heating refrigerant emerging from the evaporator so that liquid refrigerant does not reach an inlet of the compressor.

Abstract: A refrigeration system may be provided with a space-saving suction-line heat exchanger. The heat exchanger may be incorporated into a receiver. As heated liquid refrigerant enters and flows through the receiver, it may transfer heat into the heat exchanger. The heat exchanger may be connected to a suction line of the system so that refrigerant vapor and an oil-refrigerant mixture may be heated as it passes from an evaporator and into an inlet of a compressor.

Abstract: A refrigerant distribution system has a plurality of chambers formed inside a refrigerant distribution plate, each of the plurality of chambers extending from one end of the refrigerant distribution plate into the refrigerant distribution plate; and a plurality of holes formed in each of the plurality of chambers, the plurality of holes fluidly communicating each of the plurality of chambers with an outside of the refrigerant distribution place. The evaporator may be oriented such that the refrigerant flows horizontally with respect to gravity. The present invention may improve the thermal performance of the evaporator while the evaporator is oriented sub-optimally. Often, with horizontal flow through an evaporator, the refrigerant phases, liquid and vapor, may separate in the manifold, resulting in poor distribution of refrigerant in the evaporator core. The refrigerant distribution plate of the present invention evenly distributes the refrigerant in the core.

Abstract: The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2, FGFR-1, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.

Abstract: A solid oxide fuel cell system. The solid oxide fuel cell system may include a number of fuel cells placed under load in a fuel cell stack, a number of manifold slices placed under load in a manifold column, and a number of compliant feed tubes connecting the fuel cells and the manifold slices.

Abstract: The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2, FGFR-1, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.

Abstract: The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2, FGFR-1, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.