Abstract: The invention relates to biomedicine and nanomedicine, and makes it possible to enhance the diagnostic or therapeutic efficiency of an agent administered to the organism. The invention can be used to enhance methods of diagnostics and therapy of various diseases due to a more effective (passive or active) delivery of the agent to cell-targets, improved pharmacokinetic parameters of the agent (circulation time), etc.

Abstract: Method for detecting and quantifying an analyte in a liquid sample, using a test strip and magnetic particles as a detectable label and based on the detection of an amount of magnetic particles which become bound to a reading zone of a test strip as a result of performing the method, said amount being linked through a function to the analyte content of the sample, wherein the magnetic particles exhibit a nonlinear magnetization characteristic, which test strip is made of porous material and is arranged inside a case, cartridge or the like to form an assay device, wherein in its part surrounding the reading zone, the case is made of a material that is permeable to magnetic field, wherein for the reading of the reaction, the assay device is positioned in a measure cell of a magnetic reading device which detects the amount of magnetic particles in the reading zone by submitting it to at least one excitation magnetic field having about 90% of its power within one frequency band or a plurality of frequency bands,

Abstract: Disclosed is an apparatus for analysis of a mixture of biological and/or chemical components that exposes a spatially arranged chosen component attached to magnetic particles to a magnetic field and records a magnetic induction signal from which the content of the biological and/or chemical components is determined. The magnetic field is alternating and has a pre-set spectrum at least at two frequencies. The apparatus records the signal at a frequency which is a linear combination of the at least two frequencies while the magnetic particles are exposed to the magnetic field.

Abstract: Apparatus for detecting biological or chemical components in liquid or gas is based on measuring changes of the sensor layer thickness due to binding reactions. A plate or a gap with two surfaces of a solid optical material is used as the sensor layer. The surfaces are located at a distance of more than 10 ?m, which allows pumping liquids through the gap at moderate pressure drops and investigating large biological objects (e.g., cells), or employment of affordable plates that are rigid enough without any substrate. The indicated thickness of the plate or the gap permits using of the superluminescent diodes as light sources, because it allows recording within their narrow spectrum a sufficient number of interference maxima and minima for precise registration of molecular binding reactions, which lead to much higher sensitivity of the apparatus as compared with apparatus based on thin-film sensor layers.

Abstract: Method for detecting and quantifying an analyte in a liquid sample, using a test strip and magnetic particles as a detectable label and based on the detection of an amount of magnetic particles which become bound to a reading zone of a test strip as a result of performing the method, said amount being linked through a function to the analyte content of the sample, wherein the magnetic particles exhibit a nonlinear magnetization characteristic, which test strip is made of porous material and is arranged inside a case, cartridge or the like to form an assay device, wherein in its part surrounding the reading zone, the case is made of a material that is permeable to magnetic field, wherein for the reading of the reaction, the assay device is positioned in a measure cell of a magnetic reading device which detects the amount of magnetic particles in the reading zone by submitting it to at least one excitation magnetic field having about 90% of its power within one frequency band or a plurality of frequency bands,

Abstract: Disclosed is a method of analysis of a mixture of biological and/or chemical components that entails spatially arranging a chosen component attached to magnetic particles, exposing the particles to a magnetic field, and recording a magnetic induction signal, from which the content of the analyte in the mixture is judged; this includes grouping the chosen component in a probe volume, making the magnetic field alternating, pre-setting its spectrum, at least, at two frequencies, and recording the signal at a frequency, which is a linear combination of these frequencies, during the exposure of the magnetic particles to the field.

Abstract: Disclosed is an apparatus for analysis of a mixture of biological and/or chemical components that exposes a spatially arranged chosen component attached to magnetic particles to a magnetic field and records a magnetic induction signal from which the content of the biological and/or chemical components is determined. The magnetic field is alternating and has a pre-set spectrum at least at two frequencies. The apparatus records the signal at a frequency which is a linear combination of the at least two frequencies while the magnetic particles are exposed to the magnetic field.

Abstract: Apparatus for detecting biological or chemical components in liquid or gas is based on measuring changes of the sensor layer thickness due to binding reactions. A plate or a gap with two surfaces of a solid optical material is used as the sensor layer. The surfaces are located at a distance of more than 10 ?m, which allows pumping liquids through the gap at moderate pressure drops and investigating large biological objects (e.g., cells), or employment of affordable plates that are rigid enough without any substrate. The indicated thickness of the plate or the gap permits using of the superluminescent diodes as light sources, because it allows recording within their narrow spectrum a sufficient number of interference maxima and minima for precise registration of molecular binding reactions, which lead to much higher sensitivity of the apparatus as compared with apparatus based on thin-film sensor layers.

Abstract: Disclosed is a method of analysis of a mixture of biological and/or chemical components that entails spatially arranging a chosen component attached to magnetic particles, exposing the particles to a magnetic field, and recording a magnetic induction signal, from which the content of the analyte in the mixture is judged; this includes grouping the chosen component in a probe volume, making the magnetic field alternating, pre-setting its spectrum, at least, at two frequencies, and recording the signal at a frequency, which is a linear combination of these frequencies, during the exposure of the magnetic particles to the field.

Abstract: A method for detecting binding of biological and/or chemical components of liquid or gaseous mixtures and solutions, which are of mainly biological origin and/or determine parameters of living activity of biological objects, to substances that bind said components due to a biological, chemical or physical interaction; and analysis of mixtures and solutions to determine presence of biological and/or chemical components. Binding substances are arranged on a surface of or inside a sensor layer, which changes its thickness due to the binding being detected; the layer is affected by light of different wavelengths; a signal due to interference on the sensor layer is registered in the reflected or transmitted light.

Abstract: Application: detection of binding of biological and/or chemical components of liquid or gaseous mixtures and solutions, which are of mainly biological origin and/or determine parameters of living activity of biological objects, to substances that bind the said components due to a biological, chemical or physical interaction; and analysis of mixtures and solutions to determine presence of biological and/or chemical components. Essence: binding substances are arranged on a surface of or inside a sensor layer, which changes its thickness due to the binding being detected; the layer is affected by light of different wavelengths; a signal due to interference on the sensor layer is registered in the reflected or transmitted light.

Abstract: Technical field: analysis of mixtures, predominantly of biologic origin, for the contents of biological and/or chemical components, and analysis of mixtures, which parameters determine vital functions of biologic objects. Entity: spatially arranging a chosen component attached to magnetic particles, exposing the particles to a magnetic field, and recording a magnetic induction signal, from which the content of the analyte in the mixture is judged; this includes grouping the chosen component in a probe volume, making the magnetic field alternating, pre-setting its spectrum, at least, at two frequencies, and recording the signal at a frequency, which is a linear combination of these frequencies, during the exposure of the magnetic particles to the field.

Abstract: Method for detecting biological or chemical components in liquid or gas is based on measuring changes of the sensor layer thickness due to binding reactions. A plate or a gap with two surfaces of a solid optical material is used as the sensor layer. The surfaces are located at a distance of more than 10 ?m, which allows pumping liquids through the gap at moderate pressure drops and investigating large biological objects (e.g., cells), or employment of affordable plates that are rigid enough without any substrate. The indicated thickness of the plate or the gap permits using of ultra bright superluminescent diodes as light sources, because it allows recording within their narrow spectrum a sufficient number of interference maxima and minima for precise registration of molecular binding reactions, which lead to much higher sensitivity of the method as compared with thin-film methods.

Abstract: Application: detection of binding of biological and/or chemical components of liquid or gaseous mixtures and solutions, which are of mainly biological origin and/or determine parameters of living activity of biological objects, to substances that bind the said components due to a biological, chemical or physical interaction; and analysis of mixtures and solutions to determine presence of biological and/or chemical components.

Abstract: Examinations of biological, biochemical, and chemical characteristics of media, mainly of biologic origin, or media that are in contact with biological objects whose living is influenced by the media characteristics. One excites surface plasmon polaritons on a metal layer covered with a material sensitive to the examined characteristics of a medium, produces an interference with a beam of radiation reflected under these conditions and a reference beam, records parameters of a spatial intensity distribution in the resulting interference pattern, and judges the examined characteristics on the basis of the recorded parameters. The proposed method and apparatus ensure the technical result that consists in upgrading of sensitivity and resolution of measurements, at least, by two orders.

Abstract: Technical field: analysis of mixtures, predominantly of biologic origin, for the contents of biological and/or chemical components, and analysis of mixtures, which parameters determine vital functions of biologic objects.