Patents by Inventor Petr MITAS

Petr MITAS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS FOR MAKING IBRUTINIB
    Publication number: 20240092785
    Abstract: The presented invention relates to a process for preparation of Ibrutinib, comprising: a. Reacting compound of Formula (2) with compound of Formula (3) in a presence of Lewis acid to provide compound of Formula (4); b. Contacting compound of Formula (4) with toluene; c. Isolate a solid form of compound of Formula (4); d. Transforming compound of Formula (4) into Ibrutinib.
    Type: Application
    Filed: January 20, 2022
    Publication date: March 21, 2024
    Inventors: Petr MITAS, Libor VYKLICKY, Jiri BARTL, Oldrich SMEKAL
  • PROCESS FOR MAKING PALBOCICLIB
    Publication number: 20240034732
    Abstract: The present invention relates to a process for preparation of palbociclib, compound of formula (1) or a salt thereof, wherein an intermediate, compound (2), is formed by reacting a compound of formula (3) and a compound of formula (4) in a solvent mixture comprising methanol and butanol: The intermediate (2) can be transformed into palbociclib or a salt thereof.
    Type: Application
    Filed: September 26, 2023
    Publication date: February 1, 2024
    Inventors: Petr MITAS, Oldrich SMEKAL
  • Process for making palbociclib
    Patent number: 11858928
    Abstract: The present invention related to a process for preparation of compound of formula (1) or a salt thereof (i.e.
    Type: Grant
    Filed: May 21, 2019
    Date of Patent: January 2, 2024
    Assignee: Synthon B.V.
    Inventors: Petr Mitas, Oldrich Smekal
  • PROCESS FOR PREPARATION OF ENZALUTAMIDE
    Publication number: 20220242829
    Abstract: The presented invention relates to a process for preparation of Enzalutamide, compound (1) or a salt or a solvate thereof Formula (1). The presented invention also related to 1,4-dioxane solvate of compound (1).
    Type: Application
    Filed: June 25, 2020
    Publication date: August 4, 2022
    Inventors: Petr MITAS, Oldrich SMEKAL
  • A PROCESS FOR MAKING PALBOCICLIB
    Publication number: 20210206761
    Abstract: The presented invention relates to a process for preparation of compound of formula (1) or a salt thereof (i.e.
    Type: Application
    Filed: May 21, 2019
    Publication date: July 8, 2021
    Inventors: Petr MITAS, Oldrich SMEKAL
  • Pharmaceutical composition comprising sacubitril and valsartan
    Patent number: 10588892
    Abstract: The present invention relates to a pharmaceutical composition comprising a physical mixture of sacubitril sodium and valsartan disodium, wherein the X-ray powder diffraction pattern of valsartan disodium comprises characteristic peaks at the following 2 theta (±0.2) angles: 4.70°, 9.29°, 22.34°, measured using a Cu K? radiation. The invention further relates to the use of said pharmaceutical composition as medicament in the treatment of heart failure.
    Type: Grant
    Filed: July 26, 2018
    Date of Patent: March 17, 2020
    Assignee: SYNTHON B.V.
    Inventors: Bohumil Dymacek, Marta Vivancos Martinez, Luis Nogueiras Nieto, Lisardo Alvarez Fernandez, Rohit Kumar, Jose Velada Calzada, Petr Mitas
  • PHARMACEUTICAL COMPOSITION COMPRISING SACUBITRIL AND VALSARTAN
    Publication number: 20190030000
    Abstract: The present invention relates to a pharmaceutical composition comprising a physical mixture of sacubitril sodium and valsartan disodium, wherein the X-ray powder diffraction pattern of valsartan disodium comprises characteristic peaks at the following 2 theta (±0.2) angles: 4.70°, 9.29°, 22.34°, measured using a Cu K? radiation. The invention further relates to the use of said pharmaceutical composition as medicament in the treatment of heart failure.
    Type: Application
    Filed: July 26, 2018
    Publication date: January 31, 2019
    Inventors: Bohumil DYMACEK, Marta VIVANCOS MARTINEZ, Luis NOGUEIRAS NIETO, Lisardo ALVAREZ FERNANDEZ, Rohit KUMAR, Jose VELADA CALZADA, Petr MITAS