Patents by Inventor Petr Pancoska

Petr Pancoska has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PARP genomic variants conferring resistance and sensitization to chemotherapy under inhibition
    Patent number: 10260108
    Abstract: A method is provided for selecting a subject diagnosed with cancer as a candidate for treatment with a PARP1 inhibitor, or both a PARP1 inhibitor and a chemotherapeutic agent such as an alkylating agent. The method includes detecting the presence or absence of a mutation in a non-coding region of a PARP1 gene, wherein the presence of a mutation in the PARP1 gene indicates that the cancer can be treated with the PARP1 inhibitor, optionally in conjunction with the chemotherapeutic agent. In a specific, non-limiting example, the PARP1 inhibitor is verliparib (ABT-888).
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: April 16, 2019
    Assignee: UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Hussein A. Tawbi, Petr Pancoska, Panagiotis Benos, Marjorie Romkes, Andrew J. Sedgewick, Irina Abecassis
  • PARP GENOMIC VARIANTS CONFERRING RESISTANCE AND SENSITIZATION TO CHEMOTHERAPY UNDER INHIBITION
    Publication number: 20170342498
    Abstract: A method is provided for selecting a subject diagnosed with cancer as a candidate for treatment with a PARP1 inhibitor, or both a PARP1 inhibitor and a chemotherapeutic agent such as an alkylating agent. The method includes detecting the presence or absence of a mutation in a non-coding region of a PARP1 gene, wherein the presence of a mutation in the PARP1 gene indicates that the cancer can be treated with the PARP1 inhibitor, optionally in conjunction with the chemotherapeutic agent. In a specific, non-limiting example, the PARP1 inhibitor is verliparib (ABT-888).
    Type: Application
    Filed: October 30, 2015
    Publication date: November 30, 2017
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Hussein A. Tawbi, Petr Pancoska, Panagiotis Benos, Marjorie Romkes, Andrew J. Sedgewick, Irina Abecassis
  • K-PARTITE GRAPH BASED FORMALISM FOR CHARACTERIZATION OF COMPLEX PHENOTYPES IN CLINICAL DATA ANALYSES AND DISEASE OUTCOME PROGNOSIS
    Publication number: 20140200824
    Abstract: Systems and methods are disclosed that can analyze relationships between parameters in data matrices (e.g., collections of individual profiles). A graph topology can be defined on a data matrix with partitions as variables and vertices in all partitions and their potentials and edges as the co-occurrence of a pair of variable values in a profile. Individual graphs can be constructed from data and value co-occurrences for every profile, and a study data graph made as a union of all individual graphs. Heterogeneity Landmarks (HLs) can be determined from the study data graph, and graph-graph distances between individual graphs and all HLs. These distances can be used for prognoses based on similarity of a profile to one or more HLs.
    Type: Application
    Filed: March 14, 2014
    Publication date: July 17, 2014
    Applicant: University of Pittsburgh Of the Commonwealth System of Higher Education
    Inventor: Petr Pancoska
  • DISCOVERY OF t-HOMOLOGY IN A SET OF SEQUENCES AND PRODUCTION OF LISTS OF t-HOMOLOGOUS SEQUENCES WITH PREDEFINED PROPERTIES
    Publication number: 20110172930
    Abstract: System(s) and method(s) for analysis and design of genome sequences are provided. A graph representation of a genome sequence facilitates generation of a thermodynamic based quantity, e.g., an entropy-based and enthalpy-based thermodynamic tolerance [?], which in turn affords estimation of a gene sequence potential function that depends at least upon structural and functional properties of the gene sequence. The gene sequence potential (?) is determined, at least in part, via a generalized Schrödinger equation for the thermodynamic tolerance. Gene sequence potential and thermodynamic tolerance [?], and derived quantities, like thermodynamic tolerance profile and generalized homology, provide an analytic instrument for characterization of natural and synthetic gene sequences, and in conjunction with graph-based algorithms embodies a tool for design of genome sequences with predetermined properties.
    Type: Application
    Filed: September 18, 2009
    Publication date: July 14, 2011
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Petr Pancoska, Robert A. Branch, Patrick M. Dudas
  • Polynucleotides for use as tags and tag complements, manufacture and use thereof
    Patent number: 7960537
    Abstract: A family of minimally cross-hybridizing nucleotide sequences, methods of use, etc. A specific family of 210 24mers is described.
    Type: Grant
    Filed: July 18, 2007
    Date of Patent: June 14, 2011
    Assignee: Luminex Molecular Diagnostics, Inc.
    Inventors: Petr Pancoska, Vit Janota, Albert S. Benight, Richard S. Bullock, Peter V. Riccelli, Daniel Kobler, Daniel Fieldhouse
  • Polynucleotides for use as tags and tag complements, manufacture and use thereof
    Patent number: 7943322
    Abstract: A family of minimally cross-hybridizing nucleotide sequences, methods of use, etc. A specific family of 210 24 mers is described.
    Type: Grant
    Filed: October 27, 2010
    Date of Patent: May 17, 2011
    Assignee: Luminex Molecular Diagnostics, Inc.
    Inventors: Petr Pancoska, Vit Janota, Albert S. Benight, Richard S. Bullock, Peter V. Riccelli, Daniel Kobler, Daniel Fieldhouse
  • Polynucleotides for use as tags and tag complements, manufacture and use thereof
    Patent number: 7927809
    Abstract: A family of minimally cross-hybridizing nucleotide sequences, methods of use, etc. A specific family of 210 24mers is described.
    Type: Grant
    Filed: October 27, 2010
    Date of Patent: April 19, 2011
    Assignee: Luminex Molecular Diagnostics, Inc.
    Inventors: Petr Pancoska, Vit Janota, Albert S. Benight, Richard S. Bullock, Peter V. Riccelli, Daniel Kobler, Daniel Fieldhouse
  • Polynucleotides for use as tags and tag complements, manufacture and use thereof
    Patent number: 7927808
    Abstract: A family of minimally cross-hybridizing nucleotide sequences, methods of use, etc. A specific family of 210 24mers is described.
    Type: Grant
    Filed: October 27, 2010
    Date of Patent: April 19, 2011
    Assignee: Luminex Molecular Diagnostics, Inc.
    Inventors: Petr Pancoska, Vit Janota, Albert S. Benight, Richard S. Bullock, Peter V. Riccelli, Daniel Kobler, Daniel Fieldhouse
  • Polynucleotides for use as tags and tag complements, manufacture and use thereof
    Patent number: 7914997
    Abstract: A family of minimally cross-hybridizing nucleotide sequences, methods of use, etc. A specific family of 210 24mers is described.
    Type: Grant
    Filed: October 27, 2010
    Date of Patent: March 29, 2011
    Assignee: Luminex Molecular Diagnostics, Inc.
    Inventors: Petr Pancoska, Vit Janota, Albert S. Benight, Richard S. Bullock, Peter V. Riccelli, Daniel Kobler, Daniel Fieldhouse
  • POLYNUCLEOTIDES FOR USE AS TAGS AND TAG COMPLEMENTS, MANUFACTURE AND USE THEREOF
    Publication number: 20110046010
    Abstract: A family of minimally cross-hybridizing nucleotide sequences, methods of use, etc. A specific family of 210 24 mers is described.
    Type: Application
    Filed: October 27, 2010
    Publication date: February 24, 2011
    Inventors: PETR PANCOSKA, VIT JANOTA, ALBERT S. BENIGHT, RICHARD S. BULLOCK, PETER V. RICCELLI, DANIEL KOBLER, DANIEL FIELDHOUSE
  • POLYNUCLEOTIDES FOR USE AS TAGS AND TAG COMPLEMENTS, MANUFACTURE AND USE THEREOF
    Publication number: 20110039726
    Abstract: A family of minimally cross-hybridizing nucleotide sequences, methods of use, etc. A specific family of 210 24mers is described.
    Type: Application
    Filed: October 27, 2010
    Publication date: February 17, 2011
    Inventors: PETR PANCOSKA, VIT JANOTA, ALBERT S. BENIGHT, RICHARD S. BULLOCK, PETER V. RICCELLI, DANIEL KOBLER, DANIEL FIELDHOUSE
  • POLYNUCLEOTIDES FOR USE AS TAGS AND TAG COMPLEMENTS, MANUFACTURE AND USE THEREOF
    Publication number: 20110039727
    Abstract: A family of minimally cross-hybridizing nucleotide sequences, methods of use, etc. A specific family of 210 24 mers is described.
    Type: Application
    Filed: October 27, 2010
    Publication date: February 17, 2011
    Inventors: PETR PANCOSKA, VIT JANOTA, ALBERT S. BENIGHT, RICHARD S. BULLOCK, PETER V. RICCELLI, DANIEL KOBLER, DANIEL FIELDHOUSE
  • Polynucleotides for Use as Tags and Tag Complements, Manufacture and Use Thereof
    Publication number: 20110039728
    Abstract: A family of minimally cross-hybridizing nucleotide sequences, methods of use, etc. A specific family of 210 24mers is described.
    Type: Application
    Filed: October 27, 2010
    Publication date: February 17, 2011
    Inventors: PETR PANCOSKA, VIT JANOTA, ALBERT S. BENIGHT, RICHARD S. BULLOCK, PETER V. RICCELLI, DANIEL KOBLER, DANIEL FIELDHOUSE
  • Polynucleotides for use as tags and tag complements, manufacture and use thereof
    Patent number: 7846734
    Abstract: A family of minimally cross-hybridizing nucleotide sequences, methods of use, etc. A specific family of 210 24 mers is described.
    Type: Grant
    Filed: October 9, 2009
    Date of Patent: December 7, 2010
    Assignee: Luminex Molecular Diagnostics, Inc.
    Inventors: Petr Pancoska, Vit Janota, Albert S. Benight, Richard S. Bullock, Peter V. Riccelli, Daniel Kobler, Daniel Fieldhouse
  • Polynucleotides for use as tags and tag complements, manufacture and use thereof
    Patent number: 7846668
    Abstract: A family of minimally cross-hybridizing nucleotide sequences, methods of use, etc. A specific family of 210 24 mers is described.
    Type: Grant
    Filed: October 9, 2009
    Date of Patent: December 7, 2010
    Assignee: Luminex Molecular Diagnostics, Inc.
    Inventors: Petr Pancoska, Vit Janota, Albert S. Benight, Richard S. Bullock, Peter V. Riccelli, Daniel Kobler, Daniel Fieldhouse
  • Polynucleotides for use as tags and tag complements, manufacture and use thereof
    Patent number: 7846670
    Abstract: A family of minimally cross-hybridizing nucleotide sequences, methods of use, etc. A specific family of 210 24mers is described.
    Type: Grant
    Filed: October 9, 2009
    Date of Patent: December 7, 2010
    Assignee: Luminex Molecular Diagnostics, Inc.
    Inventors: Petr Pancoska, Vit Janota, Albert S. Benight, Richard S. Bullock, Peter V. Riccelli, Daniel Kobler, Daniel Fieldhouse
  • Polynucleotides for use as tags and tag complements, manufacture and use thereof
    Patent number: 7846669
    Abstract: A family of minimally cross-hybridizing nucleotide sequences, methods of use, etc. A specific family of 210 24mers is described.
    Type: Grant
    Filed: October 9, 2009
    Date of Patent: December 7, 2010
    Assignee: Luminex Molecular Diagnostics, Inc.
    Inventors: Petr Pancoska, Vit Janota, Albert S. Benight, Richard S. Bullock, Peter V. Riccelli, Daniel Kobler, Daniel Fieldhouse
  • POLYNUCLEOTIDES FOR USE AS TAGS AND TAG COMPLEMENTS, MANUFACTURE AND USE THEREOF
    Publication number: 20100216134
    Abstract: A family of minimally cross-hybridizing nucleotide sequences, methods of use, etc. A specific family of 210 24mers is described.
    Type: Application
    Filed: October 9, 2009
    Publication date: August 26, 2010
    Inventors: Petr Pancoska, Vit Janota, Albert S. Benight, Richard S. Bullock, Peter V. Riccelli, Daniel Kobler, Daniel Fieldhouse
  • POLYNUCLEOTIDES FOR USE AS TAGS AND TAG COMPLEMENTS, MANUFACTURE AND USE THEREOF
    Publication number: 20100216133
    Abstract: A family of minimally cross-hybridizing nucleotide sequences, methods of use, etc. A specific family of 210 24 mers is described.
    Type: Application
    Filed: October 9, 2009
    Publication date: August 26, 2010
    Inventors: Petr Pancoska, Vit Janota, Albert S. Benight, Richard S. Bullock, Peter V. Riccelli, Daniel Kobler, Daniel Fieldhouse
  • POLYNUCLEOTIDES FOR USE AS TAGS AND TAG COMPLEMENTS, MANUFACTURE AND USE THEREOF
    Publication number: 20100216135
    Abstract: A family of minimally cross-hybridizing nucleotide sequences, methods of use, etc. A specific family of 210 24mers is described.
    Type: Application
    Filed: October 9, 2009
    Publication date: August 26, 2010
    Inventors: Petr Pancoska, Vit Janota, Albert S. Benight, Richard S. Bullock, Peter V. Riccelli, Daniel Kobler, Daniel Fieldhouse