Patents by Inventor Petr Stehlicek
Petr Stehlicek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 12357800Abstract: A cervical dilator including a stem comprising a partly or fully dehydrated hydrogel comprising a water-insoluble synthetic hydrophilic polymer capable of radial expansion due to absorption of water from a bodily fluid. The cervical dilator softens and ripens the cervical tissue and expands the cervical canal by a combined action of radial hydrogel stem expansion and osmotic withdrawal of water from the tissue. The osmotic withdrawal is caused by at least one osmotically active compound, such as a water-soluble salt, a polyelectrolyte, or a mixture thereof, wherein the at least one osmotically active compound is dispersed in the hydrogel. The cervical dilator may also include a non-toxic plasticizer of the hydrogel, such as water.Type: GrantFiled: May 25, 2023Date of Patent: July 15, 2025Assignee: MEDICEM TECHNOLOGY S.R.O.Inventors: Vladimír Stoy, Tomas Drunecký, Miroslav Dudic, Petr Stehlicek, Zdenka Vokounova
-
Publication number: 20230293865Abstract: A cervical dilator including a stem comprising a partly or fully dehydrated hydrogel comprising a water-insoluble synthetic hydrophilic polymer capable of radial expansion due to absorption of water from a bodily fluid. The cervical dilator softens and ripens the cervical tissue and expands the cervical canal by a combined action of radial hydrogel stem expansion and osmotic withdrawal of water from the tissue. The osmotic withdrawal is caused by at least one osmotically active compound, such as a water-soluble salt, a polyelectrolyte, or a mixture thereof, wherein the at least one osmotically active compound is dispersed in the hydrogel. The cervical dilator may also include a non-toxic plasticizer of the hydrogel, such as water.Type: ApplicationFiled: May 25, 2023Publication date: September 21, 2023Inventors: Vladimír Stoy, Tomas Drunecký, Miroslav Dudic, Petr Stehlicek, Zdenka Vokounova
-
Patent number: 11660431Abstract: A cervical dilator including a stem comprising a partly or fully dehydrated hydrogel comprising a water-insoluble synthetic hydrophilic polymer capable of radial expansion due to absorption of water from a bodily fluid. The cervical dilator softens and ripens the cervical tissue and expands the cervical canal by a combined action of radial hydrogel stem expansion and osmotic withdrawal of water from the tissue. The osmotic withdrawal is caused by at least one osmotically active compound, such as a water-soluble salt, a polyelectrolyte, or a mixture thereof, wherein the at least one osmotically active compound is dispersed in the hydrogel. The cervical dilator may also include a non-toxic plasticizer of the hydrogel, such as water.Type: GrantFiled: October 6, 2017Date of Patent: May 30, 2023Assignee: MEDICEM TECHNOLOGY S.R.O.Inventors: Vladimír Stoy, Tomas Drunecký, Miroslav Dudic, Petr Stehlicek, Zdenka Vokounova
-
Publication number: 20200038640Abstract: A cervical dilator including a stem comprising a partly or fully dehydrated hydrogel comprising a water-insoluble synthetic hydrophilic polymer capable of radial expansion due to absorption of water from a bodily fluid. The cervical dilator softens and ripens the cervical tissue and expands the cervical canal by a combined action of radial hydrogel stem expansion and osmotic withdrawal of water from the tissue. The osmotic withdrawal is caused by at least one osmotically active compound, such as a water-soluble salt, a polyelectrolyte, or a mixture thereof, wherein the at least one osmotically active compound is dispersed in the hydrogel. The cervical dilator may also include a non-toxic plasticizer of the hydrogel, such as water.Type: ApplicationFiled: October 6, 2017Publication date: February 6, 2020Applicant: Medichem Technology S.R.O.Inventors: Vladimír Stoy, Tomas Drunecký, Miroslav Dudic, Petr Stehlicek, Zdenka Vokounova
-
Patent number: 9474791Abstract: The subject of the invention is a sterile, dehydrated acellular implant, which during its rehydration by water or bodily fluids displays anisotropic expansion and can act as a substrate for adhesion, migration and growth of live cells. Collagen structures of the transplant are at least partially denatured through the action of heat or organic solvents, such as lower aliphatic alcohols and ketones, which simultaneously act as preservative and sterilization agents, especially for certain types of viruses. The implant is sterilized by radiation while in an substantially dehydrated state, preferably by accelerated electrons. The transplant can be derived from various animal tissues, especially mammalian tissues, such as human or porcine tissues. The tissues suitable for the invention can be, for example, skin, placenta, pericardium, peritoneum, intestinal wall, tendon, blood vessel, etc.Type: GrantFiled: October 17, 2008Date of Patent: October 25, 2016Assignee: MEDICEM TISSUE (CY) LIMITEDInventors: Tomas Drunecky, Eva Matouskova, Petr Stehlicek, Vladimir Stoy, Pavel Vesely
-
Patent number: 7204897Abstract: The present invention is a prosthetic for replacement of at least a part of the nucleus of a intravertebral disc. The prosthetic device is composed of at least two essentially parallel soft layers of an elastically deformable hydrogel and at least one rigid layer, the rigid layer having less compressibility than the soft layers, being adjacent to the soft layers, parallel to them, and firmly attached to them. In some embodiments, the soft layers have the same thickness and composition. Typically, the prosthesis has more than one rigid layer and these rigid layers have the same thickness and composition. The number of soft layers is usually one more than the number of rigid layers, with, e.g., at least three soft layers.Type: GrantFiled: April 23, 2004Date of Patent: April 17, 2007Assignee: Replication Medical, Inc.Inventors: Vladimir A. Stoy, Petr Stehlicek, Zdena Kozlova, Tomas Drunecky
-
Publication number: 20050171611Abstract: The present invention is a prosthetic for replacement of at least a part of the nucleus of a intravertebral disc. The prosthetic device is composed of at least two essentially parallel soft layers of an elastically deformable hydrogel and at least one rigid layer, the rigid layer having less compressibility than the soft layers, being adjacent to the soft layers, parallel to them, and firmly attached to them. In some embodiments, the soft layers have the same thickness and composition. Typically, the prosthesis has more than one rigid layer and these rigid layers have the same thickness and composition. The number of soft layers is usually one more than the number of rigid layers, with, e.g., at least three soft layers.Type: ApplicationFiled: April 23, 2004Publication date: August 4, 2005Inventors: Vladimir Stoy, Petr Stehlicek, Zdena Kozlova, Tomas Drunecky
-
Patent number: 6726721Abstract: The present invention is a prosthetic for replacement of at least a part of the nucleus of a intravertebral disc. The prosthetic device is composed of at least two essentially parallel soft layers of an elastically deformable hydrogel and at least one rigid layer, the rigid layer having less compressibility than the soft layers, being adjacent to the soft layers, parallel to them, and firmly attached to them. In some embodiments, the soft layers have the same thickness and composition. Typically, the prosthesis has more than one rigid layer and these rigid layers have the same thickness and composition. The number of soft layers is usually one more than the number of rigid layers, with, e.g., at least three soft layers.Type: GrantFiled: May 10, 2001Date of Patent: April 27, 2004Assignee: Replication Medical Inc.Inventors: Vladimir A. Stoy, Petr Stehlicek, Zdena Kozlova, Tomas Drunecky
-
Patent number: 6617390Abstract: The present invention involves a method of making a multiblock copolymer containing two or more types of sequences of derivatives of acrylic acid with at least one derivative being acrylic acid salt and at least one being acrylamide. The method includes: (e) in sequence, a first step being a catalytic reaction of nitrile groups in polyacrylonitrile dissolved in an inorganic aqueous solvent of polyacrylonitrile; and, (f) at least one subsequent step being at least one catalytic reaction of nitrile groups in absence of polyacrylonitrile solvents. The present invention also pertains to the products resulting from the method.Type: GrantFiled: July 11, 2002Date of Patent: September 9, 2003Assignee: Replication Medical, Inc.Inventors: Vladimer A. Stoy, Petr Stehlicek, Zdena Kozlova, Tomas Drunecky
-
Publication number: 20030055506Abstract: The present invention is a prosthetic for replacement of at least a part of the nucleus of a intravertebral disc. The prosthetic device is composed of at least two essentially parallel soft layers of an elastically deformable hydrogel and at least one rigid layer, the rigid layer having less compressibility than the soft layers, being adjacent to the soft layers, parallel to them, and firmly attached to them. In some embodiments, the soft layers have the same thickness and composition. Typically, the prosthesis has more than one rigid layer and these rigid layers have the same thickness and composition. The number of soft layers is usually one more than the number of rigid layers, with, e.g., at least three soft layers.Type: ApplicationFiled: May 10, 2001Publication date: March 20, 2003Inventors: Vladimir A. Stoy, Petr Stehlicek, Zdena Kozlova, Tomas Drunecky
-
Publication number: 20020193531Abstract: The present invention involves a method of making a multiblock copolymer containing two or more types of sequences of derivatives of acrylic acid with at least one derivative being acrylic acid salt and at least one being acrylamide.Type: ApplicationFiled: July 11, 2002Publication date: December 19, 2002Applicant: REPLICATION MEDICAL, INC.Inventors: Vladimir A. Stoy, Petr Stehlicek, Zdena Kozlova, Tomas Drunecky
-
Patent number: 6451922Abstract: The present invention involves a method of making a multiblock copolymer containing two or more types of sequences of derivatives of acrylic acid with at least one derivative being acrylic acid salt and at least one being acrylamide. The method includes: (e) in sequence, a first step being a catalytic reaction of nitrile groups in polyacrylonitrile dissolved in an inorganic aqueous solvent of polyacrylonitrile; and, (f) at least one subsequent step being at least one catalytic reaction of nitrile groups in absence of polyacrylonitrile solvents.The present invention also pertains to the products resulting from the method.Type: GrantFiled: April 19, 2001Date of Patent: September 17, 2002Assignee: Replication Medical, Inc.Inventors: Vladimer A. Stoy, Petr Stehlicek, Zdena Kozlova, Tomas Drunecky
-
Publication number: 20010044502Abstract: The present invention involves a method of making a multiblock copolymer containing two or more types of sequences of derivatives of acrylic acid with at least one derivative being acrylic acid salt and at least one being acrylamide.Type: ApplicationFiled: April 19, 2001Publication date: November 22, 2001Applicant: Replication Medical, Inc.Inventors: Vladimir A. Stoy, Petr Stehlicek, Zdena Kozlova, Tomas Drunecky