Abstract: The present invention relates to a catalytic process for the partial reduction of esters or lactones to silyl acetals, which upon hydrolysis give aldehydes, using silanes as reducing agents, preferably triethylsilane (TESH) or 1,1,3,3-tetramethyldisiloxane (TMDS), in the presence of novel triaryl borane type catalysts. More specifically, the present invention relates to novel triaryl borane type catalyst compounds of formula (I) which can be applied for the partial reduction of an ester or lactone to a silyl acetal. In the formula R1, R?1, R5, R?5 and R6 are groups having small steric demand and R10 is a group having large steric demand.

Abstract: The present disclosure provides methods of treating inflammatory indications with complement inhibitor compounds and compositions. Included are compounds and methods of treating neuromuscular inflammatory indications, such as Immune-Mediated Necrotizing Myopathy.

Abstract: Embodiments of the present disclosure include methods of treating myasthenia gravis, including generalized myasthenia gravis, by providing C5 complement inhibitors. Included are devices and kits for inhibitor administration and methods of evaluating complement inhibitor treatment efficacy.