Patents by Inventor Petra Hofmann

Petra Hofmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions comprising fetal hemoglobin and bacterial endotoxin and optionally additional fetal liver components
    Patent number: 7968103
    Abstract: The present invention relates to a pharmaceutical composition representing a novel immunomodulating principle comprising bacterial endotoxin, fetal hemoglobin or more particularly a heme-free derivative or the ?-chain thereof, and optionally, components which are present in the fetal liver in addition to HbF. The composition is delivered to humans in a pharmaceutically acceptable carrier and/or diluent. In accordance with the present invention it was surprisingly found that endotoxin and fetal hemoglobin partial structures display a pronounced synergistic biomedical activity. The biomedical effect of fetal hemoglobin and its partial structures is surprisingly not based on a classical hemoglobin function as an oxygen transporter but related to a modulation of endotoxin-mediated bioactivity. This biomedical activity is surprisingly also observed after oral application of the composition.
    Type: Grant
    Filed: February 18, 2004
    Date of Patent: June 28, 2011
    Inventors: Otto Westphal, Josette Westphal, legal representative, Alexander Westphal, legal representative, Thierry Walli, Reginald Gorczynski, Silke Muller, Jean-Pierre Mach, Alfred Hartman, Wolfgang Bessler, Petra Hofmann, Ulrich Zahringer, Christian Alexander, Ulrich vor dem Esche, Artur J. Ulmer, Antonio Verdini
  • Compositions Comprising Fetal Hemoglobin and Bacterial Endotoxin and Optionally Additional Fetal Liver Components
    Publication number: 20080075742
    Abstract: The present invention relates to a pharmaceutical composition representing a novel immunomodulating principle comprising bacterial endotoxin, fetal hemoglobin or more particularly a heme-free derivative or the ?-chain thereof, and optionally, components which are present in the fetal liver in addition to HbF. The composition is delivered to humans in a pharmaceutically acceptable carrier and/or diluent. In accordance with the present invention it was surprisingly found that endotoxin and fetal hemoglobin partial structures display a pronounced synergistic biomedical activity. The biomedical effect of fetal hemoglobin and its partial structures is surprisingly not based on a classical hemoglobin function as an oxygen transporter but related to a modulation of endotoxin-mediated bioactivity. This biomedical activity is surprisingly also observed after oral application of the composition.
    Type: Application
    Filed: February 18, 2004
    Publication date: March 27, 2008
    Inventors: Otto Westphal, Josette Mottier Westphal, Alexander Westphal, Thierry Walli, Reginald Gorczynski, Silke Muller, Jean-Pierre Mach, Alfred Hartman, Wolfgang Bessler, Petra Hofmann, Ulrich Zahringer, Christian Alexander, Ulrich vor dem Esche, Artur J. Ulmer, Antonio Verdini