Patents by Inventor Petra Knaus

Petra Knaus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Growth factor mutants with improved biological activity
    Patent number: 9012401
    Abstract: The invention relates to novel biosynthetic growth factor mutants which exhibit improved biological activity.
    Type: Grant
    Filed: March 3, 2006
    Date of Patent: April 21, 2015
    Assignees: Biopharm Gesellschaft zur biotechnolgischen Entwicklung von Pharmaka mbH, Charite-Universitatsmedizin Berlin, Freie Universitat Berlin
    Inventors: Stefan Mundlos, Petra Knaus, Jens Pohl, Michael Kruse, Frank Plöger
  • METHOD FOR RESTORING BMP-RECEPTOR SIGNALING IN A CELL
    Publication number: 20110045568
    Abstract: The invention relates to a method for restoring BMP-receptor signaling in a cell. According to the invention, the activity of the protein cGKI is increased in a cell. Furthermore, the invention relates to the use of cGKI for the treatment of a disease selected from the group consisting of pulmonary artery hypertension (PAH), cancer, fibrosis, bone diseases, and neurodegenerative diseases, and the use of cGKI for manufacturing a pharmaceutical composition for the treatment of said diseases, the use of a BMP receptor for screening for compounds having cGKI activity, the use of cGKI for screening for receptors associated with it, and the use of cGKI for the transcriptional activation of genes containing a BMP response element.
    Type: Application
    Filed: February 27, 2009
    Publication date: February 24, 2011
    Applicant: FREIE UNIVERSITÄT BERLIN
    Inventors: Petra Knaus, Raphaela Schwappacher
  • Growth Factor Mutants With Improved Biological Activitiy
    Publication number: 20080260830
    Abstract: The invention relates to novel biosynthetic growth factor mutants which exhibit improved biological activity.
    Type: Application
    Filed: March 3, 2006
    Publication date: October 23, 2008
    Applicants: CHARITE- UNIVERSITAETSMEDIZIN BERLIN, FREIE UNIVERSITAET BERLIN, BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWI
    Inventors: Stefan Mundlos, Petra Knaus, Jens Pohl, Michael Kruse, Frank Ploger
  • Mutant forms of the TGF-beta type II receptor which bind all TGF-beta isoforms
    Publication number: 20030028905
    Abstract: The present inventtion relates to gene ession in normal cells and cells of tumors and particularly to mutant forms of the TGF-&bgr; II receptor receptor which bind ail TGF-&bgr; isoforms. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating a disease associated with mutated TGF-&bgr; type II receptor, e.g. a tumor.
    Type: Application
    Filed: July 31, 2001
    Publication date: February 6, 2003
    Inventors: Petra Knaus, Rainer Knaus