Abstract: The present invention relates to a compound represented by formula (E). The present invention also relates to a compound represented by the formula (E) for use in the treatment or prevention of diseases linked to protein aggregation and/or neurodegenerative diseases. Moreover, the present invention relates to pharmaceutical and diagnostic compositions comprising the compound of the invention as well as to a kit. Furthermore, the present invention relates to a method of imaging deposits of aggregated protein. A kit for preparing a detectably labelled compound of the present invention is also disclosed. Formula (E) wherein X, Y and L are independently nondirectionally selected from —C(R1)(R2)—, —C(R3)?, —N(R4)—, —N?, —N+(R5)?, —O— and —S—; M and Z are independently nondirectionally selected from formula (I) and formula (II).

Abstract: The present invention relates to a method of identifying a compound for inhibiting aggregation of proteins involved in diseases linked to protein aggregation and/or neurodegenerative diseases, comprising the steps of: (a) bringing into contact a labeled monomeric protein and a differently labeled aggregate of said protein in the (1) presence and (2) absence of a candidate inhibitor of aggregation, (b) determining the amount of co-localized labels, representing the extent of binding of the monomeric proteins to the aggregates of said protein; and (c) comparing the result obtained in the presence and absence of said compound, wherein a decrease of co-localized labels in the presence of said compound is indicative of the compound's ability to inhibit aggregation of said protein. Moreover, the present invention relates to a pharmaceutical composition containing said inhibitor of aggregation as well as to a kit.

Abstract: This invention relates to a steering angle sensor, particularly for yawing moment control in automotive vehicles. In order to determine the required steering angle of the steered wheels the angle of rotation of the steering wheel is measured. To this end, a code disk is used which enables the reading of the position of the angle of rotation of the disk. As the steering wheel can perform a plurality of revolutions in order to pivot the steered wheels the result readable at the code disk is ambiguous. This invention suggests a counter which records the revolutions of the code disk, starting from a zero position. Further advantageous developments involve the design of the gear mechanism and the evaluation of the signals of the counter.

Abstract: The present invention is concerned with a steer angle sensor for determining the steer angle in automotive vehicles. Sensors of the afore-mentioned type are required for controlling the driving stability. It is the object of the invention to arrange a code disk in a simple way opposite the housing of the sensor. This problem is solved, in the practice of the invention, in that the code disk is arranged directly on the housing. Advantageous developments refer to possible designs of the bearing.