Patents by Inventor Petrus Gerardus Antonius Steenbakkers

Petrus Gerardus Antonius Steenbakkers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of antibodies against specific MHC-peptide complexes
    Patent number: 7320873
    Abstract: The invention describes a method to diagnose the autoimmune disease activity by detecting the presence of an autoimmune specific MHC-peptide complex in a patient suffering from an autoimmune disease. The MHC-peptide complex is associated with rheumatoid arthritis. Monoclonals antibodies to be used for this method are also described. The antibodies can also be used for therapeutic purposes.
    Type: Grant
    Filed: August 8, 2001
    Date of Patent: January 22, 2008
    Assignee: N.V. Organon
    Inventor: Petrus Gerardus Antonius Steenbakkers
  • Use of antibodies against specific mhc-peptide complexes
    Publication number: 20040137514
    Abstract: The invention describes a method to diagnose the autoimmune disease activity by detecting the presence of an autoimmune specific MHC-peptide complex in a patient suffering from an autoimmune disease. The MHC-peptide complex is associated with rheumatoid arthritis. Monoclonals antibodies to be used for this method are also described. The antibodies can also be used for therapeutic purposes.
    Type: Application
    Filed: February 14, 2003
    Publication date: July 15, 2004
    Inventor: Petrus Gerardus Antonius Steenbakkers
  • Monoclonal antibody to the clonotypic structure of a T-cell receptor, a pharmaceutical composition and a diagnostic reagent comprising the same
    Publication number: 20020143150
    Abstract: The present invention relates to an efficient method of producing monoclonal antibodies against surface antigens of cells and viruses. The method accommodates for antigens which are present in only relatively small amounts, or antigens of which only very small amounts are available or antigens which easily lose their in vivo conformation. Thus the method according to the invention comprises a series of steps, comprising a step in which B-cells from a mammal injected with surface antigen-comprising material are enriched with respect to the relative number of specific B-cells and a step which comprises a small-scale fusion technique.
    Type: Application
    Filed: November 1, 2001
    Publication date: October 3, 2002
    Applicant: Akzo Nobel, N.W.
    Inventor: Petrus Gerardus Antonius Steenbakkers
  • Monoclonal antibody to the clonotypic structure of a T-cell receptor, a pharmaceutical compostion and a diagnostic reagent comprising the same
    Patent number: 6392020
    Abstract: The present invention relates to an efficient method of producing monoclonal antibodies against surface antigens of cells and viruses. The method accommodates for antigens which are present in only relatively small amounts, or antigens of which only very small amounts are available or antigens which easily lose their in vivo conformation. Thus the method according to the invention comprises a series of steps, comprising a step in which B-cells from a mammal injected with surface antigen-comprising material are enriched with respect to the relative number of specific B-cells and a step which comprises a small-scale fusion technique.
    Type: Grant
    Filed: September 27, 1999
    Date of Patent: May 21, 2002
    Assignee: Akzo Nobel N.V.
    Inventor: Petrus Gerardus Antonius Steenbakkers
  • Method of preparing a monoclonal antibody
    Patent number: 6020170
    Abstract: The present invention relates to an efficient method of producing monoclonal antibodies against surface antigens of cells and viruses. The method accommodates for antigens which are present in only relatively small amounts, or antigens of which only very small amounts are available or antigens which easily lose their in vivo conformation. Thus the method according to the invention comprises a series of steps, comprising a step in which B-cells from a mammal injected with surface antigen-comprising material are enriched with respect to the relative number of specific B-cells and a step which comprises a small-scale fusion technique.
    Type: Grant
    Filed: December 5, 1997
    Date of Patent: February 1, 2000
    Assignee: Akzo Nobel, N.V.
    Inventor: Petrus Gerardus Antonius Steenbakkers