Patents by Inventor Petrus J. M. Van Kerkhof

Petrus J. M. Van Kerkhof has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Controlling availability or activity of proteins by use of protease inhibitors or receptor fragments
    Patent number: 6855546
    Abstract: The invention relates to the field of proteins, more specifically to those proteins that are located on the surface of the cell. The invention, amongst others, provides an inhibitor or pharmaceutical composition that is capable of inhibiting down-regulation of a cell surface receptor. The invention provides a method to control or up-regulate hormone activity by using inhibitors or reagents that modify down-regulation of a protein. The invention further provides a method to control or up-regulate protein activity wherein ligand-induced receptor uptake and/or degradation by endocytosis of a receptor is inhibited, preferably by inhibiting the ubiquitin/proteasome system.
    Type: Grant
    Filed: September 12, 2000
    Date of Patent: February 15, 2005
    Assignee: Universiteit Utrecht
    Inventors: Gerardus Jacobus Antonius Maria Strous, Petrus J. M. Van Kerkhof, Roland Marinus Theodorus Govers