Patents by Inventor Petrus Jacobus Maria Valk

Petrus Jacobus Maria Valk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Classification, diagnosis and prognosis of acute myeloid leukemia by gene expression profiling
    Patent number: 8142994
    Abstract: The present invention relates to methods of genetic analysis for the classification, diagnosis and prognosis of acute myeloid leukemia (AML). The invention provides a method for producing a classification scheme for AML comprising the steps of a) providing a plurality of reference samples, the reference samples comprising cell samples from a plurality of reference subjects affected by AML; b) providing reference profiles by establishing a gene expression profile for each of the reference samples individually; c) clustering the individual reference profiles according to similarity; and d) assigning an AML class to each cluster. The invention further relates to a method for classifying the AML of an AML-affected subject, to a method for diagnosing AML in a subject, and to a method of determining the prognosis for an AML-affected subject.
    Type: Grant
    Filed: February 23, 2005
    Date of Patent: March 27, 2012
    Assignee: Erasmus University Medical Center Rotterdam
    Inventors: Michael John Moorhouse, Petrus Jacobus Maria Valk, Hendrik Rudolf Delwel, Bob Lowenberg, Petrus Johannes van der Spek