Patents by Inventor Petrus Johannes SIMONS
Petrus Johannes SIMONS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230242646Abstract: The disclosure describes a humanized antibody that can bind an extracellular part of human CD89 (human Fc?RI) on human CD89 expressing cells that prevents binding of human IgA to human CD89 when the antibody is bound to said cells. The disclosure also describes the use of such antibodies in combating certain diseases.Type: ApplicationFiled: April 21, 2021Publication date: August 3, 2023Inventors: Petrus Johannes Simons, Marcel Theodorus Den Hartog, Louis Boon
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Publication number: 20230052646Abstract: The invention discloses an antibody that binds an extracellular part of human HVEM on human HVEM-expressing cells, that prevents binding of BTLA to HVEM when the antibody is bound to said extracellular part of HVEM, wherein said antibody displaces BTLA bound to said extracellular part of HVEM. The invention also discloses the use of such an antibody in combating certain diseases.Type: ApplicationFiled: December 24, 2020Publication date: February 16, 2023Inventors: Louis Boon, Petrus Johannes Simons, Marcel Theodorus Den Hartog
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Patent number: 11464204Abstract: The invention relates to a device for use in large-scale industrial insect farming. More in particular, the invention relates to a live insects transport device for transporting live insects from a first location to a predetermined second location, the live insects transport device comprising a fluid guiding unit, a fluid discharge member and a feeder arrangement, wherein the live insects transport device is configured to receive live insects such as freshly hatched neonate larvae, for example of black soldier fly, wherein the live insects are taken up in a laminar flow of fluid and while in said fluid are transported to a predetermined location in the live insects transport device. Furthermore, the invention relates to the use of the device in industrial insect farming, such as large-scale farming of black soldier flies, and the invention relates to a method of dosing live insects, wherein preferably live insects are doses which are essentially of the same age, such as freshly hatched neonate larvae.Type: GrantFiled: December 21, 2018Date of Patent: October 11, 2022Assignee: Protix B.V.Inventors: Jaap van Kilsdonk, Eric Holland Schmitt, Ralf Henricus Wilhelmina Jacobs, Henricus Petrus Johannes Simons, Maurits Petrus Maria Jansen
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Publication number: 20220304287Abstract: The invention relates to a device for use in large-scale industrial insect farming. More in particular, the invention relates to an insects transport device for transporting live insects from a first location to a predetermined second location, the insects transport device comprising a gas guiding unit, a gas discharge member and a feeder arrangement, wherein the insects transport device is configured to receive live insects such as freshly hatched neonate larvae, for example of black soldier fly, or mites, wherein the live insects are directly taken up in a laminar flow of gas after exiting the feeder arrangement in a free fall under influence of gravitation such that the live insects do not contact any surface of the insects transport device, and while in said gas are transported to a predetermined location in the insects transport device. Furthermore, the invention relates to the use of the device in industrial insect farming, such as large-scale farming of black soldier flies or mites.Type: ApplicationFiled: May 20, 2020Publication date: September 29, 2022Applicant: Protix B.V.Inventors: Jaap van Kilsdonk, Eric Holland Schmitt, Ralf Henricus Wilhelmina Jacobs, Henricus Petrus Johannes Simons, Maurits Petrus Maria Jansen, Ward Tollenaar
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Publication number: 20220008937Abstract: A cyclone separation system (1K) for separating live insects carried by an air stream, comprising a main cyclone chamber (2K) having a top chamber part (3K) and a conical shaped bottom chamber part (4K). The top chamber part (3K) is connected to one or more intake channels (5K) each of which is arranged for connection to a primary air source providing an air stream (AK) comprising live insects. The bottom chamber part (4K) is connected to a discharge nozzle (6K) comprising a discharge end (7K) having a main discharge conduit (8K) for discharging the live insects from the cyclone separation system (1K), wherein the discharge end (7K) comprises an air injection member (10K) for connection to a secondary air source and wherein the air injection member (10K) is configured to inject air back into the discharge nozzle (6K).Type: ApplicationFiled: November 21, 2019Publication date: January 13, 2022Applicant: Protix B.V.Inventors: Jaap van Kilsdonk, Eric Holland Schmitt, Ralf Henricus Wilhelmina Jacobs, Henricus Petrus Johannes Simons, Maurits Petrus Maria Jansen, Ward Tollenaar, Hubertus Lourentius Hulsebos
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Publication number: 20210388084Abstract: The invention discloses an antibody that can bind an extra-cellular part of human CD89 (human Fc?RI) on human CD89 expressing cells that prevents binding of human IgA to human CD89 when the antibody is bound to said cells and that induces less cell death in said human CD89 expressing cells when compared to the antibody MIP8a. The invention also disclosed the use of such antibodies in combating certain diseases.Type: ApplicationFiled: October 24, 2019Publication date: December 16, 2021Inventors: Petrus Johannes SIMONS, Marcel Theodorus DEN HARTOG, Louis BOON
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Publication number: 20210076637Abstract: The invention relates to a device for use in large-scale industrial insect farming. More in particular, the invention relates to a live insects transport device for transporting live insects from a first location to a predetermined second location, the live insects transport device comprising a fluid guiding unit, a fluid discharge member and a feeder arrangement, wherein the live insects transport device is configured to receive live insects such as freshly hatched neonate larvae, for example of black soldier fly, wherein the live insects are taken up in a laminar flow of fluid and while in said fluid are transported to a predetermined location in the live insects transport device. Furthermore, the invention relates to the use of the device in industrial insect farming, such as large-scale farming of black soldier flies, and the invention relates to a method of dosing live insects, wherein preferably live insects are doses which are essentially of the same age, such as freshly hatched neonate larvae.Type: ApplicationFiled: December 21, 2018Publication date: March 18, 2021Applicant: Protix B.V.Inventors: Jaap van Kilsdonk, Eric Holland Schmitt, Ralf Henricus Wilhelmina Jacobs, Henricus Petrus Johannes Simons, Maurits Petrus Maria Jansen
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Patent number: 10717785Abstract: The invention relates to means and methods that relate to binding molecules that bind human complement factor C2. Specific binding molecules are described with specific C2 activity inhibiting properties. Such binding molecules are useful in the treatment of symptoms of various human diseases among which there is inflammatory disease, neuro-inflammatory disease or ischemia-reperfusion (I/R) injury disease.Type: GrantFiled: February 23, 2018Date of Patent: July 21, 2020Assignee: BROTEIO PHARMA B.V.Inventors: Cornelis Erik Hack, Cafer Yildiz, Louis Boon, Petrus Johannes Simons
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Publication number: 20190202928Abstract: The invention provides antibodies that specifically bind to human CD134. Anti-human CD134 antibodies specifically bind to the extracellular domain of human CD134, including non-OX40 ligand (OX40L) binding domains on human CD134, which is expressed on e.g. activated human conventional effector CD4 and/or CD8 T lymphocytes (Teffs) and on activated human suppressive regulatory CD4 T lymphocytes (Tregs). Humanized anti-human CD134 antibodies are useful (e.g. to empower Teffs anti-cancer effector function and/or to inhibit Tregs suppressive function) for cancer treatment.Type: ApplicationFiled: March 13, 2019Publication date: July 4, 2019Inventors: Petrus Johannes Simons, Louis Boon, Jinquan Luo, Randall Brezski, Monica Goldberg
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Patent number: 10273307Abstract: The invention provides antibodies that specifically bind to human CD134. Anti-human CD134 antibodies specifically bind to the extracellular domain of human CD134, including non-OX40 ligand (OX40L) binding domains on human CD134, which is expressed on e.g. activated human conventional effector CD4 and/or CD8 T lymphocytes (Teffs) and on activated human suppressive regulatory CD4 T lymphocytes (Tregs). Humanized anti-human CD134 antibodies are useful (e.g. to empower Teffs anti-cancer effector function and/or to inhibit Tregs suppressive function) for cancer treatment.Type: GrantFiled: September 11, 2017Date of Patent: April 30, 2019Assignees: Biocerox Products B.V., Janssen Pharmaceuticals, Inc.Inventors: Petrus Johannes Simons, Louis Boon, Jinquan Luo, Randall Brezski, Monica Goldberg
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Publication number: 20180319895Abstract: The invention relates to means and methods that relate to binding molecules that bind human complement factor C2. Specific binding molecules are described with specific C2 activity inhibiting properties. Such binding molecules are useful in the treatment of symptoms of various human diseases among which there is inflammatory disease, neuro-inflammatory disease or ischemia-reperfusion (I/R) injury disease.Type: ApplicationFiled: February 23, 2018Publication date: November 8, 2018Inventors: Cornelis Erik Hack, Cafer Yildiz, Louis Boon, Petrus Johannes Simons
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Publication number: 20180273632Abstract: The invention provides antibodies that specifically bind to human CD134. Invention anti human CD134 antibodies specifically bind to the extracellular domain of human CD134, including non-OX40 ligand (OX40L) binding domains on human CD134, which is expressed on e.g. activated human conventional effector CD4 and/or CD8 T lymphocytes (Teffs) and on activated human suppressive regulatory CD4 T lymphocytes (Tregs). Invention anti-human CD134 antibodies are useful (e.g. to empower Teffs anti-cancer effector function and/or to inhibit Tregs suppressive function) for cancer treatment.Type: ApplicationFiled: May 22, 2018Publication date: September 27, 2018Inventors: Petrus Johannes Simons, Louis Boon
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Patent number: 9944717Abstract: The invention relates to means and methods that relate to binding molecules that bind human complement factor C2. Specific binding molecules are described with specific C2 activity inhibiting properties. Such binding molecules are useful in the treatment of symptoms of various human diseases among which there is inflammatory disease, neuro-inflammatory disease or ischemia-reperfusion (I/R) injury. Disease.Type: GrantFiled: May 22, 2014Date of Patent: April 17, 2018Assignee: Broteio Pharma B.V.Inventors: Cornelis Erik Hack, Cafer Yildiz, Louis Boon, Petrus Johannes Simons
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Publication number: 20170369586Abstract: The invention provides antibodies that specifically bind to human CD134. Anti-human CD134 antibodies specifically bind to the extracellular domain of human CD134, including non-OX40 ligand (OX40L) binding domains on human CD134, which is expressed on e.g. activated human conventional effector CD4 and/or CD8 T lymphocytes (Teffs) and on activated human suppressive regulatory CD4 T lymphocytes (Tregs). Humanized anti-human CD134 antibodies are useful (e.g. to empower Teffs anti-cancer effector function and/or to inhibit Tregs suppressive function) for cancer treatment.Type: ApplicationFiled: September 11, 2017Publication date: December 28, 2017Inventors: Petrus Johannes SIMONS, Louis BOON, Jinquan LUO, Randall BREZSKI, Monica GOLDBERG
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Patent number: 9790281Abstract: The invention provides antibodies that specifically bind to human CD134. Anti-human CD134 antibodies specifically bind to the extracellular domain of human CD134, including non-OX40 ligand (OX40L) binding domains on human CD134, which is expressed on e.g. activated human conventional effector CD4 and/or CD8 T lymphocytes (Teffs) and on activated human suppressive regulatory CD4 T lymphocytes (Tregs). Humanized anti-human CD134 antibodies are useful (e.g. to empower Teffs anti-cancer effector function and/or to inhibit Tregs suppressive function) for cancer treatment.Type: GrantFiled: March 20, 2014Date of Patent: October 17, 2017Assignees: BiocerOX Products, B.V., Janssen Pharmaceuticals, Inc.Inventors: Petrus Johannes Simons, Louis Boon, Jinquan Luo, Randall Brezski, Monica Goldberg
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Publication number: 20170051069Abstract: The invention provides antibodies that specifically bind to human CD134. Invention anti-human CD134 antibodies specifically bind to the extracellular domain of human CD134, including non-OX40 ligand (OX40L) binding domains on human CD134, which is expressed on e.g. activated human conventional effector CD4 and/or CD8 T lymphocytes (Teffs) and on activated human suppressive regulatory CD4 lymphocytes (Tregs). Invention anti-human CD134 antibodies are useful (e.g. to empower Teffs anti-cancer effector function and/or to inhibit Tregs suppressive function) for cancer treatment.Type: ApplicationFiled: August 25, 2016Publication date: February 23, 2017Inventors: Petrus Johannes Simons, Louis Boon
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Patent number: 9475880Abstract: The invention provides antibodies that specifically bind to human CD134. Invention anti-human CD134 antibodies specifically bind to the extracellular domain of human CD134, including non-OX40 ligand (OX40L) binding domains on human CD134, which is expressed on e.g. activated human conventional effector CD4 and/or CD8 T lymphocytes (Teffs) and on activated human suppressive regulatory CD4 T lymphocytes (Tregs). Invention anti-human CD134 antibodies are useful (e.g. to empower Teffs anti-cancer effector function and/or to inhibit Tregs suppressive function) for cancer treatment.Type: GrantFiled: September 13, 2012Date of Patent: October 25, 2016Assignees: Biocerox Products, B.V., Janssen Pharmaceuticals, Inc.Inventors: Petrus Johannes Simons, Louis Boon
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Publication number: 20160108134Abstract: The invention relates to means and methods that relate to binding molecules that bind human complement factor C2. Specific binding molecules are described with specific C2 activity inhibiting properties. Such binding molecules are useful in the treatment of symptoms of various human diseases among which there is inflammatory disease, neuro-inflammatory disease or ischemia-reperfusion (I/R) injury. Disease.Type: ApplicationFiled: May 22, 2014Publication date: April 21, 2016Inventors: CORNELIS ERIK HACK, CAFER YILDIZ, LOUIS BOON, PETRUS JOHANNES SIMONS
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Publication number: 20150132288Abstract: The invention provides antibodies that specifically bind to human CD134. Invention anti-human CD134 antibodies specifically bind to the extracellular domain of human CD134, including non-OX40 ligand (OX40L) binding domains on human CD134, which is expressed on e.g. activated human conventional effector CD4 and/or CD8 T lymphocytes (Teffs) and on activated human suppressive regulatory CD4 T lymphocytes (Tregs). Invention anti-human CD134 antibodies are useful (e.g. to empower Teffs anti-cancer effector function and/or to inhibit Tregs suppressive function) for cancer treatment.Type: ApplicationFiled: September 13, 2012Publication date: May 14, 2015Applicant: BiocerOX Products B.V.Inventors: Petrus Johannes Simons, Louis Boon
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Publication number: 20140377284Abstract: The invention provides antibodies that specifically bind to human CD134. Anti-human CD134 antibodies specifically bind to the extracellular domain of human CD134, including non-OX40 ligand (OX40L) binding domains on human CD134, which is expressed on e.g. activated human conventional effector CD4 and/or CD8 T lymphocytes (Teffs) and on activated human suppressive regulatory CD4 T lymphocytes (Tregs). Humanized anti-human CD134 antibodies are useful (e.g. to empower Teffs anti-cancer effector function and/or to inhibit Tregs suppressive function) for cancer treatment.Type: ApplicationFiled: March 20, 2014Publication date: December 25, 2014Applicants: JANSSEN PHARMACEUTICALS, INC., BIOCEROX PRODUCTS B.V.Inventors: Petrus Johannes SIMONS, Louis BOON, Jinquan LUO, Randall BREZSKI, Monica GOLDBERG