Patents by Inventor Petrus Johannes van der Spek

Petrus Johannes van der Spek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Classification, diagnosis and prognosis of acute myeloid leukemia by gene expression profiling
    Patent number: 8142994
    Abstract: The present invention relates to methods of genetic analysis for the classification, diagnosis and prognosis of acute myeloid leukemia (AML). The invention provides a method for producing a classification scheme for AML comprising the steps of a) providing a plurality of reference samples, the reference samples comprising cell samples from a plurality of reference subjects affected by AML; b) providing reference profiles by establishing a gene expression profile for each of the reference samples individually; c) clustering the individual reference profiles according to similarity; and d) assigning an AML class to each cluster. The invention further relates to a method for classifying the AML of an AML-affected subject, to a method for diagnosing AML in a subject, and to a method of determining the prognosis for an AML-affected subject.
    Type: Grant
    Filed: February 23, 2005
    Date of Patent: March 27, 2012
    Assignee: Erasmus University Medical Center Rotterdam
    Inventors: Michael John Moorhouse, Petrus Jacobus Maria Valk, Hendrik Rudolf Delwel, Bob Lowenberg, Petrus Johannes van der Spek
  • Classification, Diagnosis and Prognosis of Acute Myeloid Leukemia by Gene Expression Profiling
    Publication number: 20080305965
    Abstract: The present invention relates to method of genetic analysis for the classification, diagnosis and prognosis of acute myeloid leukemia (AML). The invention provides a method for producing a classification scheme for AML comprising the steps of a) providing a plurality of reference samples, said reference samples comprising cell samples from a plurality of reference subjects affected by AML; b) providing reference profiles by establishing a gene expression profile for each of said reference samples individually; c) clustering said individual reference profiles according to similarity; and d) assigning an AML class to each cluster. The invention further relates to a method for classifying the AML of an AML affected subject, to a method for diagnosing AML in a subject, and to a method of determining the prognosis for an AML affected subject.
    Type: Application
    Filed: February 23, 2005
    Publication date: December 11, 2008
    Applicant: ERASMUS UNIVERSITEIT ROTTERDAM
    Inventors: Michael John Moorhouse, Petrus Jaobus Maria Valk, Hendrik Rudolf Delwell, Bob Lowenberg, Petrus Johannes van der Spek