Patents by Inventor Petrus Theodorus Maria Biessels

Petrus Theodorus Maria Biessels has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hemoglobin composition and preparation thereof
    Patent number: 5646252
    Abstract: The described invention relates to an essentially stroma-free hemoglobin composition evidencing properties suitable for use as a universally applicable blood plasma expander and to a method for the preparation thereof. Typical, of these properties are desirable oxygen affinity values, desirable vascular retention time and substantial absence of toxic side effects. The described composition comprises human hemoglobin cross-linked intramolecularly through the beta-chains and polymerized with glutaraldehyde. Intramolecular cross-linking is typically effected with 2-nor-2-formylpyridoxal 5-phosphate or a bis-pyridoxal polyphosphate.
    Type: Grant
    Filed: October 16, 1995
    Date of Patent: July 8, 1997
    Assignee: Staat der Nederlanden, De Minister van Defensie, voor deze: Het Hoofd van de Afdeling Militair Geneeskundig Beleid
    Inventors: Wilhelmus Antonius Berbers, Petrus Theodorus Maria Biessels, Willem Karel Bleeker, Joachim Cornelis Bakker