Patents by Inventor Peyman Najmabadi
Peyman Najmabadi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11921125Abstract: A slide rack inventory and reinsertion system for use with a digital slide scanning apparatus is provided that determines, prior to scanning of glass slides in a slide rack, a status of each slot in the slide rack as properly occupied, improperly occupied, or empty. The system also determines whether a slide that has been removed from the slide rack for processing has been properly reinserted into the slide rack.Type: GrantFiled: January 10, 2022Date of Patent: March 5, 2024Assignee: LEICA BIOSYSTEMS IMAGING, INC.Inventors: Nicholas Newberg, Prentash Djelosevic, Aaron Stearrett, Peyman Najmabadi
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Patent number: 11704003Abstract: Graphical user interface for managing a workflow of a slide scanning system. In an embodiment, the graphical user interface comprises a graphical representation of a carousel used by the scanning system. The graphical representation of the carousel comprises a graphical representation of each of a plurality of rack slots, configured to receive slide racks. The graphical representation of the carousel indicates a position of the carousel, and the graphical representation of each of the plurality of rack slots indicates a status of the represented rack slot and/or a slide rack within the represented rack slot.Type: GrantFiled: August 6, 2020Date of Patent: July 18, 2023Assignee: LEICA BIOSYSTEMS IMAGING, INC.Inventors: Timothy Dailey, Peyman Najmabadi, Nicholas Newberg, Paul Georgief, Lance Mikus, Prentash Djelosevic
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Publication number: 20220357565Abstract: Real-time autofocus. In an embodiment, a scanning apparatus includes an imaging sensor, a focusing sensor, an objective lens, and processor(s) configured to analyze image data captured by the imaging and focusing sensors, and move the objective lens. Real-time autofocus during scanning of a sample is achieved by determining a true-Z value for the objective lens for a point on a sample and for each of a plurality of regions on the sample. The true-Z values and/or surfaces calculated therefrom are used to determine a predicted-Z value for an unscanned region of the sample. The objective lens is adjusted to the predicted-Z value at the beginning of the unscanned region. After scanning the region, a true-Z value is determined for the region and compared to the predicted-Z value. A rescan of the region is initiated if the comparison exceeds a predetermined threshold.Type: ApplicationFiled: July 21, 2022Publication date: November 10, 2022Inventors: Leng-Chun CHEN, Allen OLSON, Yunlu ZOU, Peyman NAJMABADI, Greg CRANDALL
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Publication number: 20220326494Abstract: Control processes for a slide-scanning system comprising a carousel with a plurality of rack slots configured to receive slide racks via an exposed portion of the scanning system. In an embodiment, initializing the scanning system comprises automatically homing back-end and front-end components, wherein the front-end components comprise the carousel. An inventory of all slide racks in the carousel is automatically generated. If any slide rack was being processed by any back-end components, the slide rack is automatically unloaded into a corresponding rack slot. In addition, the carousel is automatically positioned to expose a starting subset of the rack slots within the exposed portion. This starting subset may comprise a maximum segment of adjacent empty rack slots.Type: ApplicationFiled: August 5, 2020Publication date: October 13, 2022Inventors: Peyman NAJMABADI, Nicholas NEWBERG, Prentash DJELOSEVIC, Aaron STEARRETT
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Patent number: 11454781Abstract: A digital scanning apparatus is provided that includes imaging and focusing sensors and a processor to analyze the image data captured by the imaging and focusing sensors and adjust the focus of the scanning apparatus in real time during a scanning operation. The individual pixels of the imaging sensor are all in the same image plane with respect to the optical path of the digital scanning apparatus. The individual pixels of the focusing sensor are each in a different image plane with respect to the optical path, and one pixel of the focusing sensor is on the same image plane as the image sensor. The processor analyzes image data from the imaging sensor and the focusing sensor and determines a distance and direction to adjust the relative position of an objective lens and a stage of the digital scanning apparatus to achieve optimal focus during the scanning operation.Type: GrantFiled: October 30, 2020Date of Patent: September 27, 2022Assignee: Leica Biosystems Imaging, Inc.Inventors: Allen Olson, Kiran Saligrama, Yunlu Zou, Peyman Najmabadi
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Publication number: 20220283679Abstract: Graphical user interface for managing a workflow of a slide scanning system. In an embodiment, the graphical user interface comprises a graphical representation of a carousel used by the scanning system. The graphical representation of the carousel comprises a graphical representation of each of a plurality of rack slots, configured to receive slide racks. The graphical representation of the carousel indicates a position of the carousel, and the graphical representation of each of the plurality of rack slots indicates a status of the represented rack slot and/or a slide rack within the represented rack slot.Type: ApplicationFiled: August 6, 2020Publication date: September 8, 2022Inventors: Timothy DAILEY, Peyman NAJMABADI, Nicholas NEWBERG, Paul GEORGIEF, Lance MIKUS, Prentash DJELOSEVIC
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Patent number: 11434082Abstract: A stuck slide determination system is provided that determines if a slide (e.g., glass slide), positioned on a scanning stage at the start of the scanning process, gets stuck and does not move along with the scanning stage after the scanning process commences. In an embodiment, the system includes a sensor having a transmitter and receiver that are relatively positioned to detect the presence of the stage or a slide or the absence of the stage or a slide. When the scanning stage begins to move at the start of the scanning process, a processor monitors a signal from the sensor and determines if the slide is improperly positioned after the scanning process has commenced. If the slide is improperly positioned, the processor stops movement of the scanning stage in order to protect the slide from damage.Type: GrantFiled: May 18, 2020Date of Patent: September 6, 2022Assignee: Leica Biosystems Imaging, Inc.Inventors: Nicholas Newberg, Prentash Djelosevic, Aaron Stearrett, Peyman Najmabadi
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Patent number: 11422350Abstract: System for acquiring a digital image of a sample on a microscope slide. In an embodiment, the system comprises a stage configured to support a sample, an objective lens having a single optical axis that is orthogonal to the stage, an imaging sensor, and a focusing sensor. The system further comprises at least one beam splitter optically coupled to the objective lens and configured to receive a field of view corresponding to the optical axis of the objective lens, and simultaneously provide at least a first portion of the field of view to the imaging sensor and at least a second portion of the field of view to the focusing sensor. The focusing sensor may simultaneously acquire image(s) at a plurality of different focal distances and/or simultaneously acquire a pair of mirrored images, each comprising pixels acquired at a plurality of different focal distances.Type: GrantFiled: March 13, 2020Date of Patent: August 23, 2022Assignee: Leica Biosystems Imaging, Inc.Inventors: Yunlu Zou, Allen Olson, Kiran Saligrama, Ruby Chen, Peyman Najmabadi, Greg Crandall
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Patent number: 11422351Abstract: Real-time autofocus. In an embodiment, a scanning apparatus includes an imaging sensor, a focusing sensor, an objective lens, and processor(s) configured to analyze image data captured by the imaging and focusing sensors, and move the objective lens. Real-time autofocus during scanning of a sample is achieved by determining a true-Z value for the objective lens for a point on a sample and for each of a plurality of regions on the sample. The true-Z values and/or surfaces calculated therefrom are used to determine a predicted-Z value for an unscanned region of the sample. The objective lens is adjusted to the predicted-Z value at the beginning of the unscanned region. After scanning the region, a true-Z value is determined for the region and compared to the predicted-Z value. A rescan of the region is initiated if the comparison exceeds a predetermined threshold.Type: GrantFiled: November 25, 2020Date of Patent: August 23, 2022Assignee: Leica Biosystems Imaging, Inc.Inventors: Leng-Chun Chen, Allen Olson, Yunlu Zou, Peyman Najmabadi, Greg Crandall
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Publication number: 20220196686Abstract: A slide rack inventory and reinsertion system for use with a digital slide scanning apparatus is provided that determines, prior to scanning of glass slides in a slide rack, a status of each slot in the slide rack as properly occupied, improperly occupied, or empty. The system also determines whether a slide that has been removed from the slide rack for processing has been properly reinserted into the slide rack.Type: ApplicationFiled: January 10, 2022Publication date: June 23, 2022Inventors: Nicholas Newberg, Prentash Djelosevic, Aaron Stearrett, Peyman Najmabadi
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Patent number: 11221343Abstract: A slide rack inventory and reinsertion system for use with a digital slide scanning apparatus is provided that determines, prior to scanning of glass slides in a slide rack, a status of each slot in the slide rack as properly occupied, improperly occupied, or empty. The system also determines whether a slide that has been removed from the slide rack for processing has been properly reinserted into the slide rack.Type: GrantFiled: October 23, 2020Date of Patent: January 11, 2022Assignee: Leica Biosystems Imaging, Inc.Inventors: Nicholas Newberg, Prentash Djelosevic, Aaron Stearrett, Peyman Najmabadi
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Publication number: 20210103134Abstract: Real-time autofocus. In an embodiment, a scanning apparatus includes an imaging sensor, a focusing sensor, an objective lens, and processor(s) configured to analyze image data captured by the imaging and focusing sensors, and move the objective lens. Real-time autofocus during scanning of a sample is achieved by determining a true-Z value for the objective lens for a point on a sample and for each of a plurality of regions on the sample. The true-Z values and/or surfaces calculated therefrom are used to determine a predicted-Z value for an unscanned region of the sample. The objective lens is adjusted to the predicted-Z value at the beginning of the unscanned region. After scanning the region, a true-Z value is determined for the region and compared to the predicted-Z value. A rescan of the region is initiated if the comparison exceeds a predetermined threshold.Type: ApplicationFiled: November 25, 2020Publication date: April 8, 2021Inventors: Leng-Chun CHEN, Allen OLSON, Yunlu ZOU, Peyman NAJMABADI, Greg CRANDALL
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Patent number: 10955650Abstract: Two-pass capture of a macro image. In an embodiment, a scanning apparatus comprises a stage, a high-resolution camera, and a lens that provides a field of view, substantially equal in width to a slide width, to the high-resolution camera. The apparatus also comprises a first illumination system for transmission-mode illumination, and a second illumination system for reflection-mode illumination. Processor(s) move the stage in a first direction to capture a first macro image of a specimen during a single pass while the field of view is illuminated by the first illumination system, and move the stage in a second direction to capture a second macro image of the specimen during a single pass while the field of view is illuminated by the second illumination system. The processor(s) identify artifacts in the second macro image, and, based on those artifacts, correct the first macro image to generate a modified first macro image.Type: GrantFiled: March 6, 2020Date of Patent: March 23, 2021Assignee: LEICA BIOSYSTEMS IMAGING, INC.Inventors: Leng-Chun Chen, Yunlu Zou, Allen Olson, Peyman Najmabadi, Greg Crandall, Nicholas Newberg, Aaron Stearrett
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Publication number: 20210055317Abstract: A slide rack inventory and reinsertion system for use with a digital slide scanning apparatus is provided that determines, prior to scanning of glass slides in a slide rack, a status of each slot in the slide rack as properly occupied, improperly occupied, or empty. The system also determines whether a slide that has been removed from the slide rack for processing has been properly reinserted into the slide rack.Type: ApplicationFiled: October 23, 2020Publication date: February 25, 2021Inventors: Nicholas NEWBERG, Prentash DJELOSEVIC, Aaron STEARRETT, Peyman NAJMABADI
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Publication number: 20210048606Abstract: A digital scanning apparatus is provided that includes imaging and focusing sensors and a processor to analyze the image data captured by the imaging and focusing sensors and adjust the focus of the scanning apparatus in real time during a scanning operation. The individual pixels of the imaging sensor are all in the same image plane with respect to the optical path of the digital scanning apparatus. The individual pixels of the focusing sensor are each in a different image plane with respect to the optical path, and one pixel of the focusing sensor is on the same image plane as the image sensor. The processor analyzes image data from the imaging sensor and the focusing sensor and determines a distance and direction to adjust the relative position of an objective lens and a stage of the digital scanning apparatus to achieve optimal focus during the scanning operation.Type: ApplicationFiled: October 30, 2020Publication date: February 18, 2021Inventors: Allen OLSON, Kiran SALIGRAMA, Yunlu ZOU, Peyman NAJMABADI
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Patent number: 10895726Abstract: Apparatus and methods for scanning a 2D or 3D image of a specimen without relative Z-axis motion between the specimen and the objective lens. In an embodiment, the apparatus includes a tilted camera having individual lines of pixels. Each line of pixels can be separately processed and is at a different image plane with respect to the stage. The depth of field of each line of pixels abuts, slightly overlaps, or is slightly spaced apart from the adjacent lines of pixels in the tilted camera. The angle of the tilt determines the relationship (abut, overlapping, or spaced) of the adjacent lines of pixels. The individual image lines produced by each line of pixels can be combined into a 3D volume image of a sample. Also, the highest-contrast line at each X-Y location can be combined into an in-focus 2D image of the sample.Type: GrantFiled: December 5, 2019Date of Patent: January 19, 2021Assignee: LEICA BIOSYSTEMS IMAGING, INC.Inventors: Yunlu Zou, Peyman Najmabadi
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Publication number: 20200385218Abstract: A stuck slide determination system is provided that determines if a slide (e.g., glass slide), positioned on a scanning stage at the start of the scanning process, gets stuck and does not move along with the scanning stage after the scanning process commences. In an embodiment, the system includes a sensor having a transmitter and receiver that are relatively positioned to detect the presence of the stage or a slide or the absence of the stage or a slide. When the scanning stage begins to move at the start of the scanning process, a processor monitors a signal from the sensor and determines if the slide is improperly positioned after the scanning process has commenced. If the slide is improperly positioned, the processor stops movement of the scanning stage in order to protect the slide from damage.Type: ApplicationFiled: May 18, 2020Publication date: December 10, 2020Inventors: Nicholas NEWBERG, Prentash DJELOSEVIC, Aaron STEARRETT, Peyman NAJMABADI
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Patent number: 10852523Abstract: Real-time autofocus. In an embodiment, a scanning apparatus includes an imaging sensor, a focusing sensor, an objective lens, and processor(s) configured to analyze image data captured by the imaging and focusing sensors, and move the objective lens. Real-time autofocus during scanning of a sample is achieved by determining a true-Z value for the objective lens for a point on a sample and for each of a plurality of regions on the sample. The true-Z values and/or surfaces calculated therefrom are used to determine a predicted-Z value for an unscanned region of the sample. The objective lens is adjusted to the predicted-Z value at the beginning of the unscanned region. After scanning the region, a true-Z value is determined for the region and compared to the predicted-Z value. A rescan of the region is initiated if the comparison exceeds a predetermined threshold.Type: GrantFiled: November 5, 2019Date of Patent: December 1, 2020Assignee: LEICA BIOSYSTEMS IMAGING, INC.Inventors: Leng-Chun Chen, Allen Olson, Yunlu Zou, Peyman Najmabadi, Greg Crandall
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Patent number: 10823936Abstract: A digital scanning apparatus is provided that includes imaging and focusing sensors and a processor to analyze the image data captured by the imaging and focusing sensors and adjust the focus of the scanning apparatus in real time during a scanning operation. The individual pixels of the imaging sensor are all in the same image plane with respect to the optical path of the digital scanning apparatus. The individual pixels of the focusing sensor are each in a different image plane with respect to the optical path, and one pixel of the focusing sensor is on the same image plane as the image sensor. The processor analyzes image data from the imaging sensor and the focusing sensor and determines a distance and direction to adjust the relative position of an objective lens and a stage of the digital scanning apparatus to achieve optimal focus during the scanning operation.Type: GrantFiled: October 14, 2019Date of Patent: November 3, 2020Assignee: LEICA BIOSYSTEMS IMAGING, INC.Inventors: Allen Olson, Kiran Saligrama, Yunlu Zou, Peyman Najmabadi
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Patent number: D931875Type: GrantFiled: December 16, 2019Date of Patent: September 28, 2021Assignee: Leica Biosystems Imaging, Inc.Inventors: Timothy Dailey, Nicholas Newberg, Peyman Najmabadi, Lance Mikus, Prentash Djelosevic