Abstract: Agglomeration process in agglomeration plants is quite sensitive to changes in input feed material characteristics. End-to-end optimization of the agglomerate process by combining all the units is difficult due to unique complexities and challenges associated with combining the individual process outputs. A method and system for optimizing the operation of an agglomeration plant has been provided. The system performs real time optimization on integrated wet agglomeration and thermal agglomeration process which subsequently increases the plant productivity and agglomerate quality and minimizes the operating cost and emissions from the plant. The optimization process involves various steps such as receiving data, pre-processing of data, prediction using physics-based and data-driven models of agglomeration plant, and optimization execution and configuration. The process also involves continuous monitoring of model performance and self-learning of the models in case of a performance drift.