Abstract: Sustained release pharmaceutical dosage forms include a core containing at least one swellable, water soluble, pH independent polymer and a first water insoluble, pH independent polymer, and a permeable membrane coat containing a swellable, water soluble, pH independent polymer and a second water insoluble, pH independent polymer. The sustained release pharmaceutical dosage forms are free of osmagens and/or diluents and demonstrate similar release characteristics as compared to known sustained release formulations that contain osmagens and/or diluents. Additionally, the release profile for the sustained release pharmaceutical dosage forms is resistant to dose dumping in the presence of alcohol.

Abstract: Oral dosage forms for basic amine drugs, the dosage forms having a gastro-retentive component and a non gastro-retentive component. These dosage forms are capable of providing both IR and SR release rates for these drugs. In addition, they provide for release of the drug in the stomach and/or intestine of a mammal to which such dosage forms are administered. Such dosage forms include tablets and capsules. Such dosage forms provide improved bioavailability of otherwise poorly bioavailable basic amine drugs.