Abstract: The present invention includes novel molecules and methods for using the same to treat Alcohol Use Disorder (AUD), Substance Use Disorder (SUD), tobacco use, pain, or proinflammatory disorders comprising: identifying a subject in need of treatment for at least one of AUD, SUD, pain, or a proinflammatory disorder; and providing the subject with an effective amount of a modified minocycline to ameliorate or eliminate the AUD, SUD, pain, or proinflammatory disorder and that has reduced, or no, antimicrobial activity, wherein the modified tetracycline has a formula, e.g., or the modified doxycycline, minocycline, and tigecycline and their tautomerized structures, where the R-groups shown in the minocycline example above could be different combination of halogen, acetyl ester, methyl ester, and diacetal.

Abstract: The present invention includes novel molecules and methods for using the same to treat Alcohol Use Disorder (AUD), Substance Use Disorder (SUD), tobacco use, pain, or proinflammatory disorders comprising: identifying a subject in need of treatment for at least one of AUD, SUD, pain, or a proinflammatory disorder; and providing the subject with an effective amount of a modified minocycline to ameliorate or eliminate the AUD, SUD, pain, or proinflammatory disorder and that has reduced, or no, antimicrobial activity, wherein the modified tetracycline has a formula, e.g., or the modified doxycycline, minocycline, and tigecycline and their tautomerized structures, where the R-groups shown in the minocycline example above could be different combination of halogen, acetyl ester, methyl ester, and diacetal.

Abstract: A method of treating Alcohol Use Disorder (AUD), Substance Use Disorder (SUD), tobacco use, pain, or proinflammatory disorders comprising: providing a subject with an effective amount of a modified tetracycline or derivative thereof to ameliorate or eliminate the AUD, SUD, tobacco use, pain, or proinflammatory disorder, and wherein the modified tetracycline or derivative thereof has reduced binding to a microbial ribosome and has the formula: wherein R1 is acetyl, R2 is OH or acetyl, R3 is acetyl, R4 is H or acetyl, and R5 is acetyl.

Abstract: A method of treating Alcohol Use Disorder (AUD), Substance Use Disorder (SUD), tobacco use, pain, or proinflammatory disorders comprising: providing a subject with an effective amount of a modified tetracycline or derivative thereof to ameliorate or eliminate the AUD, SUD, tobacco use, pain, or proinflammatory disorder, and wherein the modified tetracycline or derivative thereof has reduced binding to a microbial ribosome and has the formula: wherein R1 is acetyl, R2 is OH or acetyl, R3 is acetyl, R4 is H or acetyl, and R5 is acetyl.

Abstract: A method of treating Alcohol Use Disorder (AUD), Substance Use Disorder (SUD), tobacco use, pain, or proinflammatory disorders comprising: providing a subject with an effective amount of a modified tetracycline or derivative thereof to ameliorate or eliminate the AUD, SUD, tobacco use, pain, or proinflammatory disorder, and wherein the modified tetracycline or derivative thereof has reduced binding to a microbial ribosome and has the formula: wherein R1 is acetyl, R2 is OH or acetyl, R3 is acetyl, R4 is H or acetyl, and R5 is acetyl.

Abstract: A method of treating Alcohol Use Disorder (AUD), Substance Use Disorder (SUD), tobacco use, pain, or proinflammatory disorders comprising: providing a subject with an effective amount of a modified tetracycline or derivative thereof to ameliorate or eliminate the AUD, SUD, tobacco use, pain, or proinflammatory disorder, and wherein the modified tetracycline or derivative thereof has reduced binding to a microbial ribosome and has the formula wherein R1 is acetyl, R2 is OH or acetyl, R3 is acetyl, R4 is H or acetyl, and R5 is acetyl.

Abstract: A method of treating Alcohol Use Disorder (AUD), Substance Use Disorder (SUD), tobacco use, pain, or proinflammatory disorders comprising: providing a subject with an effective amount of a modified tetracycline or derivative thereof to ameliorate or eliminate the AUD, SUD, tobacco use, pain, or proinflammatory disorder, and wherein the modified tetracycline or derivative thereof has reduced binding to a microbial ribosome and has the formula wherein R1 is acetyl, R2 is OH or acetyl, R3 is acetyl, R4 is H or acetyl, and R5 is acetyl.

Abstract: The present invention includes novel molecules and methods for using the same to treat Alcohol Use Disorder (AUD), Substance Use Disorder (SUD), tobacco use, pain, or proinflammatory disorders comprising: identifying a subject in need of treatment for at least one of AUD, SUD, pain, or a proinflammatory disorder; and providing the subject with an effective amount of a modified minocycline to ameliorate or eliminate the AUD, SUD, pain, or proinflammatory disorder and that has reduced, or no, antimicrobial activity, wherein the modified tetracycline has a formula, e.g., or the modified doxycycline, minocycline, and tigecycline and their tautomerized structures, where the R-groups shown in the minocycline example above could be different combination of halogen, acetyl ester, methyl ester, and diacetal.

Abstract: A mainframe computing system includes a central processor complex, and a plurality of billing entities, each billing entity having a respective capacity limit, and a workload manager that schedules work requested by the plurality of billing entities on the central processor complex and tracks, by billing entity, a rolling average of service units. The mainframe computing system also includes a dynamic capping policy for the central processor complex that identifies a maximum service unit limit, a subset of the plurality of billing entities, and, for each identified billing entity, information from which to determine a service unit entitlement value. The mainframe computing system also includes a dynamic capping master that adjusts the respective capacity limits of the subset of the plurality of billing entities at scheduled intervals based on the dynamic capping policy to favor billing entities having high-importance workload within the maximum service unit limit.

Abstract: A mainframe computing system includes a central processor complex, and a plurality of billing entities, each billing entity having a respective capacity limit, and a workload manager that schedules work requested by the plurality of billing entities on the central processor complex and tracks, by billing entity, a rolling average of service units. The mainframe computing system also includes a dynamic capping policy for the central processor complex that identifies a maximum service unit limit, a subset of the plurality of billing entities, and, for each identified billing entity, information from which to determine a service unit entitlement value. The mainframe computing system also includes a dynamic capping master that adjusts the respective capacity limits of the subset of the plurality of billing entities at scheduled intervals based on the dynamic capping policy to favor billing entities having high-importance workload within the maximum service unit limit.

Abstract: A mainframe computing system includes a central processor complex, and a plurality of billing entities, each billing entity having a respective capacity limit, and a workload manager that schedules work requested by the plurality of billing entities on the central processor complex and tracks, by billing entity, a rolling average of service units. The mainframe computing system also includes a dynamic capping policy for the central processor complex that identifies a maximum service unit limit, a subset of the plurality of billing entities, and, for each identified billing entity, information from which to determine a service unit entitlement value. The mainframe computing system also includes a dynamic capping master that adjusts the respective capacity limits of the subset of the plurality of billing entities at scheduled intervals based on the dynamic capping policy to favor billing entities having high-importance workload within the maximum service unit limit.

Abstract: Different transmissions based on different content blocks which were segmented from the same digital content according to different segmentation schemes, where each of the content blocks has any substring in common with at least one of the other content blocks, are received by a receiving radio communication station, for example a mobile telephone or a mobile network base station. Certain encoded received bits derived from different ones of the transmissions are combined into combined bits. Other encoded received bits derived from one or more of the different transmissions are provided together with the combined bits to a decoder.

Abstract: A method and system of decoding a ccnvolutionally encoded data block having known padding bits. A Viterbi decoder is constrained to a state corresponding to k?1 padding bits immediately adjacent to data bits of the data block, where k is a constraint length of a convolution encoder used to encode the data block. Symbols of the encoded data block that have influence only from the padding bits are discarded.

Abstract: Different transmissions based on different content blocks which were segmented from the same digital content according to different segmentation schemes, where each of the content blocks has any substring in common with at least one of the other content blocks, are received by a receiving radio communication station, for example a mobile telephone or a mobile network base station. Certain encoded received bits derived from different ones of the transmissions are combined into combined bits. Other encoded received bits derived from one or more of the different transmissions are provided together with the combined bits to a decoder.

Abstract: A method and apparatus for automatic frequency control in a receiver of a wireless device, the method determining a channel estimation for a received signal; calculating a signal to noise ratio for the channel estimation; applying a weighting factor determined based on the calculated signal to noise ratio for the channel estimation to the channel estimation to create a weighted channel estimation; and supplying the weighted channel estimation to a voltage controlled oscillator.

Abstract: Different transmissions based on different content blocks which were segmented from the same digital content according to different segmentation schemes, where each of the content blocks has any substring in common with at least one of the other content blocks, are received by a receiving radio communication station, for example a mobile telephone or a mobile network base station. Certain encoded received bits derived from different ones of the transmissions are combined into combined bits. Other encoded received bits derived from one or more of the different transmissions are provided together with the combined bits to a decoder.

Abstract: A method and system of decoding a convolutionally encoded data block having known padding bits. A Viterbi decoder is constrained to a state corresponding to k?1 padding bits immediately adjacent to data bits of the data block, where k is a constraint length of a convolution encoder used to encode the data block. Symbols of the encoded data block that have influence only from the padding bits are discarded.