Patents by Inventor Pher G. Andersson

Pher G. Andersson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Phenyl inden-1-one compounds
    Patent number: 6790998
    Abstract: The invention relates to a process for the enantioselective preparation of tolterodine and analogues and salts thereof comprises the steps of: a) enantioselectively reducing the carbonyl function in a compound of formula (II): wherein R1, R2 and R3 independently of each other are hydrogen, methyl, methoxy, hydroxy, hydroxymethyl, carbamoyl, sulphamoyl or halogen, to form an enantiomerically enriched compound of formula (IIIa) or (IIIb): wherein R1, R2 and R3 are as defined above; b) subjecting the compound of formula (IIIa) or (IIIb) to a sigmatropic rearrangement to form a corresponding enantiomerically enriched compound of formula (IVa) or (IVb): wherein R1, R2 and R3 are as defined above; c) subjecting the compound of formula (IVa) or (IVb) to a Baeyer-Villiger oxidation to form a corresponding enantiomerically enriched compound of the general formula (Va) or (Vb).
    Type: Grant
    Filed: March 28, 2003
    Date of Patent: September 14, 2004
    Assignee: Pharmacia AB
    Inventors: Pher G. Andersson, Christian Hedberg
  • Phenyl propenone compounds
    Patent number: 6689916
    Abstract: The invention relates to a process for the enantioselective preparation of tolterodine and analogues and salts thereof comprises the steps of: a) enantioselectively reducing the carbonyl function in a compound of formula (II):  wherein R1, R2 and R3 independently of each other are hydrogen, methyl, methoxy, hydroxy, hydroxymethyl, carbamoyl, sulphamoyl or halogen, to form an enantiomerically enriched compound of formula (IIIa) or (IIIb):  wherein R1, R2 and R3 are as defined above; b) subjecting the compound of formula (IIIa) or (IIIb) to a sigmatropic rearrangement to form a corresponding enantiomerically enriched compound of formula (IVa) or (IVb):  wherein R1, R2 and R3 are as defined above; c) subjecting the compound of formula (IVa) or (IVb) to a Baeyer-Villiger oxidation to form a corresponding enantiomerically enriched compound of the general formula (Va) or (Vb): wherein R1, R2 and R3 are as defined above; d) co
    Type: Grant
    Filed: March 28, 2003
    Date of Patent: February 10, 2004
    Assignee: Pharmacia AB
    Inventors: Pher G. Andersson, Christian Hedberg
  • Phenyl propenone compounds
    Publication number: 20030204114
    Abstract: The invention relates to a process for the enantioselective preparation of tolterodiine and analogues and salts thereof comprises the steps of:
    Type: Application
    Filed: March 28, 2003
    Publication date: October 30, 2003
    Inventors: Pher G. Andersson, Christian Hedberg
  • Phenyl inden-1-one compounds
    Publication number: 20030191348
    Abstract: The invention relates to a process for the enantioselective preparation of tolterodine and analogues and salts thereof comprises the steps of:
    Type: Application
    Filed: March 28, 2003
    Publication date: October 9, 2003
    Inventors: Pher G. Andersson, Christian Hedberg
  • Process and intermediates
    Patent number: 6566537
    Abstract: The invention relates to a process for the enantioselective preparation of tolterodine and analogues and salts thereof comprises the steps of: a) enantioselectively reducing the carbonyl function in a compound of formula (II): wherein R1, R2 and R3 independently of each other are hydrogen, methyl, methoxy, hydroxy, hydroxymethyl, carbamoyl, sulphamoyl or halogen, to form an enantiomerically enriched compound of formula (IIIa) or (IIIb): wherein R1, R2 and R3 are as defined above; b) subjecting the compound of formula (IIIa) or (IIb) to a sigmatropic rearrangement to form a corresponding enantiomerically enriched compound of formula (IVa) or (IVb): wherein R1, R2 and R3 are as defined above; c) subjecting the compound of formula (IVa) or (IVb) to a Baeyer-Villiger oxidation to form a corresponding enantiomerically enriched compound of the general formula (Va) or (Vb): wherein R1, R2 and R3 are as defined above; d) converting the compou
    Type: Grant
    Filed: July 31, 2001
    Date of Patent: May 20, 2003
    Assignee: Pharmacia AB
    Inventors: Pher G. Andersson, Christian Hedberg
  • 3,5-Dioxa-8-aza-tricyclo[5.2.1.00,0]decane-9-methanols, their metal complexes and enantio-selective hydrogenation processes
    Patent number: 6534653
    Abstract: Compounds of the formula I, in the form of their racemates, mixtures of stereoisomers or mainly pure stereoisomers in which Y is C1-C4alkylene or —SiR1R2—; X is a carbon atom and A1 and A2 independently of one another are hydrogen, C1-C12alkyl, C2-C12alkenyl, C3-C8cycloalkyl, C3-C8cycloalkenyl, C3-C8cycloalkyl-C1-C4alkyl, C3-C8cycloalkenyl-C1-C4alkyl, C6-C10aryl or C7-C14aralkyl; or X is a silicon atom and A1 and A2 independently of one another are C1-C12alkyl, C3-C8cycloalkyl, C3-C8cycloalkyl-C1-C4alkyl, C6-C10aryl or C7-C14aralkyl; A3 and A4 independently of one another are hydrogen, C1-C12alkyl, C3-C8cycloalkyl, C3-C8-cycloalkyl-C1-C4alkyl, C6-C10aryl or C7-C14aralkyl; and R1 and R2 independently of one another are C1-C6alkyl, cyclohexyl, phenyl or benzyl, are ligands for metal complexes of the eighth sub-group of the Periodic Table of the Elements, which are suitable as catalysts for asymmetric hydrogenations and transfer hydrogenations of prochiral compounds having car
    Type: Grant
    Filed: April 10, 2001
    Date of Patent: March 18, 2003
    Assignee: Solvias AG
    Inventors: Pher G. Andersson, Sofia J. M. Nordin, Peter Roth
  • 3,5-Dioxa-8-aza-tricyclo[5.2.1.00,0]decane-9-methanols, their metal complexes and enantio-selective hydrogenation processes
    Publication number: 20020061815
    Abstract: Compounds of the formula I, in the form of their racemates, mixtures of stereoisomers or mainly pure stereoisomers 1
    Type: Application
    Filed: April 10, 2001
    Publication date: May 23, 2002
    Inventors: Pher G. Andersson, Sofia J.M. Nordin, Peter Roth
  • Novel process and intermediates
    Publication number: 20020019568
    Abstract: The invention relates to a process for the enantioselective preparation of tolterodine and analogues and salts thereof comprises the steps of:
    Type: Application
    Filed: July 31, 2001
    Publication date: February 14, 2002
    Inventors: Pher G. Andersson, Christian Hedberg
  • Process and intermediates
    Patent number: 6310248
    Abstract: The invention relates to a process for the enantioselective preparation of tolterodine and analogues and salts thereof comprises the steps of: a) enantioselectively reducing the carbonyl function in a compound of formula (II): wherein R1, R2 and R3 independently of each other are hydrogen, methyl, methoxy, hydroxy, hydroxymethyl, carbamoyl, sulphamoyl or halogen, to form an enantiomerically enriched compound of formula (IIIa) or (IIIb): wherein R1, R2 and R3 are as defined above; b) subjecting the compound of formula (IIIa) or (IIIb) to a sigmatropic rearrangement to form a corresponding enantiomerically enriched compound of formula (IVa) or (IVb): wherein R1, R2 and R3 are as defined above; c) subjecting the compound of formula (IVa) or (IVb) to a Baeyer-Virliger oxidation to form a corresponding enantiomerically enriched compound of the general formula (Va) or (Vb): wherein R1, R2 and R3 are as defined above; d) converting the compo
    Type: Grant
    Filed: December 22, 2000
    Date of Patent: October 30, 2001
    Assignee: Pharmacia AB
    Inventors: Pher G. Andersson, Christian Hedberg
  • Novel process and intermediates
    Publication number: 20010016669
    Abstract: The invention relates to a process for the enantioselective preparation of tolterodine and analogues and salts thereof comprises the steps of:
    Type: Application
    Filed: December 22, 2000
    Publication date: August 23, 2001
    Inventors: Pher G. Andersson, Christian Hedberg