Patents by Inventor Phil BARAN

Phil BARAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PHOSPHOROUS (V)-BASED REAGENTS, PROCESSES FOR THE PREPARATION THEREOF, AND THEIR USE IN MAKING STEREO-DEFINED ORGANOPHOSHOROUS (V) COMPOUNDS
    Publication number: 20230242569
    Abstract: The present invention relates to novel phosphorous (V) (P(V)) reagents, methods for preparing thereof, and methods for preparing organophosphorous (V) compounds by using the novel reagents.
    Type: Application
    Filed: February 10, 2023
    Publication date: August 3, 2023
    Inventors: Michael Anthony SCHMIDT, Bin ZHENG, Kyle KNOUSE, Justine deGRUYTER, Martin D. EASTGATE, Phil BARAN, William R. EWING, Richard E. OLSON, Ivar M. MCDONALD
  • Phosphorous (V)-based reagents, processes for the preparation thereof, and their use in making stereo-defined organophoshorous (V) compounds
    Patent number: 11613554
    Abstract: The present invention relates to novel phosphorous (V) (P(V)) reagents, methods for preparing thereof, and methods for preparing organophosphorous (V) compounds by using the novel reagents.
    Type: Grant
    Filed: April 12, 2019
    Date of Patent: March 28, 2023
    Assignees: Bristol-Myers Squibb Company, The Scripps Research Institute
    Inventors: Michael Anthony Schmidt, Bin Zheng, Kyle Knouse, Justine deGruyter, Martin D. Eastgate, Phil Baran, William R. Ewing, Richard E. Olson, Ivar M. McDonald
  • CU-AND NI-CATALYZED DECARBOXYLATIVE BORYLATION REACTIONS
    Publication number: 20220024949
    Abstract: The invention is directed to methods of converting a carboxylic acid group in a compound, via a redox active ester, to a corresponding boronic ester by treatment with bis(pinacolato)diboron-alkyllithium complex in the presence of a ligand, a Ni(II) salt or a copper salt, and an Mg(II) salt, in the presence of an alkyllithium or a lithium hydroxide or alkoxide salt. The product pinacolato boronate ester can be cleaved to provide a boronic acid. The invention is also directed to methods of preparing various compounds of medical value comprising boronic acid groups, and to novel boronic-acid containing compounds of medicinal value, including an atorvastatin boronic acid analog, a vancomycin aglycone boronic acid analog, and boronic acid containing elastase inhibitors mCBK319, mCBK320, mCBK323, and RPX-7009.
    Type: Application
    Filed: September 30, 2021
    Publication date: January 27, 2022
    Inventors: Phil Baran, Chao Li, Jie Wang, Amab K. Chatterjee, Manoj Kumar, Shan Yu, Kristen Johnson, Tian Qin, Ming Shang
  • PROCESS OF ALPHA,BETA-DESATURATION OF COMPOUNDS CONTAINING A CARBONYL MOIETY
    Publication number: 20210387936
    Abstract: The present invention relates to a new process of ?,?-desaturation of compounds containing a carbonyl moiety, in particular, ketones, esters, amides, lactones, lactams and aldehydes.
    Type: Application
    Filed: June 9, 2021
    Publication date: December 16, 2021
    Inventors: Phil BARAN, Samer GNAIM, Pierre-Georges ECHEVERRIA, Laurent PETIT
  • Cu- and Ni-catalyzed decarboxylative borylation reactions
    Patent number: 11161859
    Abstract: The invention is directed to methods of converting a carboxylic acid group in a compound, via a redox active ester, to a corresponding boronic ester by treatment with bis(pinacolato)diboron-alkyllithium complex in the presence of a ligand, a Ni(ll) salt or a copper salt, and an Mg(ll) salt, in the presence of an alkyllithium or a lithium hydroxide or alkoxide salt. The product pinacolato boronate ester can be cleaved to provide a boronic acid. The invention is also directed to methods of preparing various compounds of medical value comprising boronic acid groups, and to novel boronic-acid containing compounds of medicinal value, including an atorvastatin boronic acid analog, a vancomycin aglycone boronic acid analog, and boronic acid containing elastase inhibitors mCBK319, mCBK320, mCBK323, and RPX-7009.
    Type: Grant
    Filed: March 14, 2018
    Date of Patent: November 2, 2021
    Assignee: THE SCRIPPS RESEARCH INSTITUTE
    Inventors: Phil Baran, Chao Li, Jie Wang, Arnab Kumar Chatterjee, Manoj Kumar, Shan Yu, Kristen Ann Johnson, Tian Qin, Ming Shang
  • COMPOUNDS FOR ORGANIC LIGHT EMITTING DIODE MATERIALS
    Publication number: 20200321533
    Abstract: Described herein are molecules for use in organic light emitting diodes comprising at least one moiety A, at least one moiety D, and at least one moiety B.
    Type: Application
    Filed: May 23, 2017
    Publication date: October 8, 2020
    Inventors: Alan Aspuru-Guzik, Rafael Gomez-Bombarelli, Timothy D. Hirzel, Jorge Aguilera-Iparraguirre, Phil Baran
  • Cu- and Ni-Catalyzed Decarboxylative Borylation Reactions
    Publication number: 20200024290
    Abstract: The invention is directed to methods of converting a carboxylic acid group in a compound, via a redox active ester, to a corresponding boronic ester by treatment with bis(pinacolato)diboron-alkyllithium complex in the presence of a ligand, a Ni(11) salt or a copper salt, and an Mg(11) salt, in the presence of an alkyllithium or a lithium hydroxide or alkoxide salt. The product pinacolato boronate ester can be cleaved to provide a boronic acid. The invention is also directed to methods of preparing various compounds of medical value comprising boronic acid groups, and to novel boronic-acid containing compounds of medicinal value, including an atorvastatin boronic acid analog, a vancomycin aglycone boronic acid analog, and boronic acid containing elastase inhibitors mCBK319, mCBK320, mCBK323, and RPX-7009.
    Type: Application
    Filed: March 14, 2018
    Publication date: January 23, 2020
    Inventors: Phil Baran, Chao Li, Jie Wang, Arnab Kumar Chatterjee, Manoj Kumar, Shan Yu, Kristen Ann Johnson, Tian Qin, Ming Shang
  • NOVEL PHOSPHOROUS (V)-BASED REAGENTS, PROCESSES FOR THE PREPARATION THEREOF, AND THEIR USE IN MAKING STEREO-DEFINED ORGANOPHOSHOROUS (V) COMPOUNDS
    Publication number: 20190322694
    Abstract: The present invention relates to novel phosphorous (V) (P(V)) reagents, methods for preparing thereof, and methods for preparing organophosphorous (V) compounds by using the novel reagents.
    Type: Application
    Filed: April 12, 2019
    Publication date: October 24, 2019
    Inventors: Michael Anthony SCHMIDT, Bin ZHENG, Kyle KNOUSE, Justine deGRUYTER, Martin D. EASTGATE, Phil BARAN, William R. EWING, Richard E. OLSON, Ivar M. McDONALD