Abstract: Various embodiments provide novel tools and techniques for providing graded exercise therapy. A system includes one or more sensors coupled to a patient, and a host machine coupled to the one or more sensors. The host machine includes a processor, and a computer readable medium in communication with the processor having encoded thereon a set of instructions executable by the processor to establish a graded exercise therapy regime for the patient, determine one or more physiologic data targets for the patient, obtain a first set of physiologic data of the patient during the graded exercise therapy regime, and update the one or more physiologic data targets based, at least in part, on the first set of physiologic data.