Abstract: The present invention provides a method of producing a co-crystal, the method comprising the steps of providing a first substance and a second substance, wherein the first and second substances are compatible to form a co-crystal, mixing said first and second substances together, and exposing the mixture of said first and second substances to prolonged and sustained conditions of pressure and shear, sufficient to form a co-crystal of said first and second substance. The prolonged and sustained conditions of pressure and shear are preferably applied in an extrusion process. Associated compositions and uses thereof are also provided.

Abstract: The present invention provides a raulti-layer heat-shrinkable film comprising: a first outer layer comprising a polyester; a second outer layer comprising a polyester; an inner layer comprising a polyolefin; a first intermediate layer between the first outer layer and the inner layer comprising polypropylene grafted with glycidyl methacrylate either directly or through a graft promoter; and a second intermediate layer between the second outer layer and the inner layer comprising polypropylene grafted with glycidyl methacrylate either directly or through a graft promoter.